Radiotherapy plus a self-gelation powder encapsulating tRF5-GlyGCC inhibitor potentiates natural kill cell immunity to prevent hepatocellular carcinoma recurrence

• Published in: Journal of nanobiotechnology Vol. 23; no. 1; pp. 100 - 23
• Main Authors: Gong, Yihang, Zeng, Fanxin, Zhang, Feng, Liu, Xiaoquan, Li, Zhongheng, Chen, Wenjie, Liu, Haipeng, Li, Xin, Cheng, Yusheng, Zhang, Jian, Feng, Yeqian, Wu, Tiangen, Zhou, Wence, Zhang, Tong
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 10.02.2025; BioMed Central; BMC
• Subjects: Animals; Carcinoma, Hepatocellular - immunology; Carcinoma, Hepatocellular - pathology; Carcinoma, Hepatocellular - radiotherapy; Carcinoma, Hepatocellular - therapy; Cell Line, Tumor; Diseases; Health aspects; Hepatocellular carcinoma; Hepatoma; Humans; Immune response; Killer cells; Killer Cells, Natural - drug effects; Killer Cells, Natural - immunology; Liver Neoplasms - immunology; Liver Neoplasms - radiotherapy; Liver Neoplasms - therapy; Male; Medical research; Medicine, Experimental; Mice; Mice, Inbred C57BL; Nanocomposite hydrogel; Neoplasm Recurrence, Local - prevention & control; NK cell immunity; Physiological aspects; Prevention; Radiotherapy; Relapse; TRNA-derived fragments; China; Hepatocellular carcinoma; Nanocomposite hydrogel; Radiotherapy; NK cell immunity; TRNA-derived fragments

Hepatocellular carcinoma (HCC) recurrence postresection represents a thorny problem in clinical practice, of which impaired natural killer (NK) cell cytotoxicity represents one of crucial causes. Apart from recurrence, hepatectomy-induced abdominal adhesion also poses huge clinical challenges such a...