Long noncoding RNA MIR31HG inhibits hepatocellular carcinoma proliferation and metastasis by sponging microRNA-575 to modulate ST7L expression

• Published in: Journal of experimental & clinical cancer research Vol. 37; no. 1; pp. 214 - 16
• Main Authors: Yan, Shaoying, Tang, Zhenrong, Chen, Ke, Liu, Yuyang, Yu, Gangfeng, Chen, Qiuxu, Dang, Hao, Chen, Fengjiao, Ling, Jiaji, Zhu, Liying, Huang, Ailong, Tang, Hua
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 03.09.2018; BioMed Central; BMC
• Subjects: Adult; Aged; Angiogenesis; Animals; Apoptosis; Bioinformatics; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - pathology; Cell Line, Tumor; Cell Movement - genetics; Cell proliferation; Cell Proliferation - genetics; Female; Gastric cancer; Gene Expression Regulation, Neoplastic - genetics; Genes; HCC; Hepatocellular carcinoma; Humans; Liver cancer; Liver Neoplasms - genetics; Liver Neoplasms - pathology; Lung cancer; Male; Medical prognosis; Metastasis; Mice; MicroRNAs; MicroRNAs - genetics; Middle Aged; miR-575; MIR31HG; Neoplasm Metastasis; Patient outcomes; Prognosis; Proliferation; Regulation; RNA, Long Noncoding - genetics; RNA-Binding Proteins - genetics; Roles; ST7L; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays; ST7L; miR-575; HCC; Metastasis; Proliferation; MIR31HG
• ISSN: 0392-9078; 1756-9966; 1756-9966
• DOI: 10.1186/s13046-018-0853-9

Emerging evidences have indicated that long noncoding RNAs (lncRNAs) play essential roles in the development and progression of cancers. Dysregulation of lncRNA MIR31HG has recently been reported in several types of cancers, and researches on the function of MIR31HG in cancers suggested that MIR31HG...