D3‐creatine dilution for skeletal muscle mass measurement: historical development and current status

• Published in: Journal of cachexia, sarcopenia and muscle Vol. 13; no. 6; pp. 2595 - 2607
• Main Authors: McCarthy, Cassidy, Schoeller, Dale, Brown, Justin C., Gonzalez, M. Cristina, Varanoske, Alyssa N., Cataldi, Devon, Shepherd, John, Heymsfield, Steven B.
• Format: Journal Article
• Language: English
• Published: Heidelberg John Wiley & Sons, Inc 01.12.2022; Wiley - Society on Sarcopenia, Cachexia and Wasting Disorders; John Wiley and Sons Inc; Wiley
• Subjects: Adults; Biochemistry; Biopsy; body composition; Creatinine; Estimates; isotope dilution; Malnutrition; Methods; Musculoskeletal system; nutritional assessment; Physiology; Proteins; Review; Reviews; Urine

The French chemist Michel Eugène Chevreul discovered creatine in meat two centuries ago. Extensive biochemical and physiological studies of this organic molecule followed with confirmation that creatine is found within the cytoplasm and mitochondria of human skeletal muscles. Two groups of investiga...