Genetic regulation of TERT splicing affects cancer risk by altering cellular longevity and replicative potential - Florez-Vargas, Oscar; Ho, Michelle; Hogshead, Maxwell H.; Papenberg, Brenen W.; Lee, Chia-Han; Forsythe, Kaitlin; Jones, Kristine; Luo, Wen; Teshome, Kedest; Blauwendraat, Cornelis; Billingsley, Kimberley J.; Kolmogorov, Mikhail; et al. (Nature communications, 2025)
Keywords: 13/106; 13/109; 13/2; 13/31; 14/19; 38/88; 42/35; 42/44; 45/23; 45/41; 45/43; 45/91; 631/208/200; 631/208/205; 631/208/68; Age; Alleles; Alternative splicing; Alternative Splicing - genetics; Apoptosis; Apoptosis - genetics; Bioinformatics; Cancer; Cell Line, Tumor; Cell proliferation; Cell Proliferation - genetics; Chromosome 5; Clonal deletion; CRISPR; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Genome-wide association studies; Genome-Wide Association Study; Haplotypes; Health risks; Humanities and Social Sciences; Humans; Introns - genetics; Loci; Longevity; Minisatellite Repeats - genetics; multidisciplinary; Neoplasms - genetics; Neoplasms - pathology; Polymorphism, Single Nucleotide; Risk; RNA-directed DNA polymerase; Science; Science (multidisciplinary); Telomerase; Telomerase - genetics; Telomerase - metabolism; Telomerase reverse transcriptase; Telomeres