Analysis of post-transcriptional regulatory signatures and immune cell subsets in premature ovarian insufficiency based on full-length transcriptome

• Published in: Scientific reports Vol. 15; no. 1; pp. 5533 - 13
• Main Authors: Yu, Zhaoyang, Zhang, Xiqian, Nong, Yingqi, Ding, Hongfan, Fu, Xiaoqian, Li, Feiwen, Liu, Lidan, Li, Mujun, Peng, Weilong, Wu, Huimei, Liu, Fenghua
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 14.02.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 631/114; 631/1647; 631/208; 631/337; 631/61; Adult; Alternative polyadenylation; Alternative Splicing; Case-Control Studies; CD8 antigen; Endocrine disorders; Female; Ferroptosis; Full-length transcriptome; Gene Expression Profiling; Gene Expression Regulation; Gene regulation; Genetic analysis; Genetic diversity; Humanities and Social Sciences; Humans; Immune cell subtypes; Immunotherapy; Infertility; Isoforms; Lymphocytes T; Monocytes; multidisciplinary; Ovaries; Pathogenesis; Peripheral blood; Polyadenylation; Post-transcription; Premature ovarian insufficiency; Primary Ovarian Insufficiency - genetics; Primary Ovarian Insufficiency - immunology; RNA, Long Noncoding - genetics; Science; Science (multidisciplinary); Transcription factors; Transcriptome; Transcriptomes; Alternative splicing; Alternative polyadenylation; Premature ovarian insufficiency; Immune cell subtypes; Full-length transcriptome

Premature ovarian insufficiency (POI) is a reproductive endocrine disorder characterized by infertility and the perimenopausal syndrome. Its genetic etiology is highly heterogeneous and not yet fully understood. Limited by short-read sequencing, the profile and structural variation of the full-lengt...