Cross-species transcriptomics translation reveals a role for the unfolded protein response in Mycobacterium tuberculosis infection

• Published in: NPJ systems biology and applications Vol. 11; no. 1; pp. 19 - 13
• Main Authors: Pullen, Krista M., Finethy, Ryan, Ko, Seung-Hyun B., Reames, Charlotte J., Sassetti, Christopher M., Lauffenburger, Douglas A.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 15.02.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 631/114; 631/553; Animal models; Animals; Asymptomatic; Bioinformatics; Biology; Biomedical and Life Sciences; Cell activation; Cellular stress response; Computational Biology/Bioinformatics; Computer Appl. in Life Sciences; Disease; Disease Models, Animal; Gene Expression Profiling - methods; Genotype & phenotype; Humans; Infections; Inflammatory bowel disease; Life Sciences; Macrophages; Macrophages - metabolism; Macrophages - microbiology; Mathematical models; Mice; Mycobacterium tuberculosis; Mycobacterium tuberculosis - genetics; Mycobacterium tuberculosis - pathogenicity; Pathophysiology; Phenotypes; Phenotypic variations; Protein folding; Proteins; Species Specificity; Systems Biology; Transcriptome - genetics; Transcriptomics; Tuberculosis; Tuberculosis - genetics; Tuberculosis - immunology; Tuberculosis - microbiology; Unfolded Protein Response - genetics

Numerous studies have identified similarities in blood transcriptomic signatures of tuberculosis (TB) phenotypes between mice and humans, including type 1 interferon production and innate immune cell activation. However, murine infection pathophysiology is distinct from human disease. We hypothesize...