Population pharmacokinetics, enzyme occupancy, and 24S‐hydroxycholesterol modeling of soticlestat, a novel cholesterol 24‐hydroxylase inhibitor, in healthy adults - Yin, Wei; Facius, Axel; Wagner, Thomas; Tsai, Max; Asgharnejad, Mahnaz; Lahu, Gëzim; Vakilynejad, Majid (Clinical and translational science, 2023)
Keywords: Administration, Oral; Adult; Bioavailability; Child; Cholesterol; Cholesterol 24-Hydroxylase; Clinical trials; Design optimization; Dosage; Drug dosages; Enzymes; Epilepsy; Humans; Metabolism; Metabolites; Models, Biological; Oral administration; Pediatrics; Pharmacodynamics; Pharmacokinetics; Plasma; Simulation