The carbon monoxide prodrug oCOm‐21 increases Ca2+ sensitivity of the cardiac myofilament

• Published in: Physiological reports Vol. 12; no. 6; pp. e15974 - n/a
• Main Authors: Payne, Fergus M., Nie, Samantha, Diffee, Gary M., Wilkins, Gerard T., Larsen, David S., Harrison, Joanne C., Baldi, James C., Sammut, Ivan A.
• Format: Journal Article
• Language: English
• Published: Oxford John Wiley & Sons, Inc 01.03.2024; John Wiley and Sons Inc; Wiley
• Subjects: Calcium (intracellular); calcium sensitivity; Carbon monoxide; Cardiac arrhythmia; Cardiomyocytes; Cytotoxicity; Heart; Heart rate; Heme; Hemopexin; Laboratory animals; myofilament; Original; Phosphatase; Phosphorylation

Patients undergoing cardiopulmonary bypass procedures require inotropic support to improve hemodynamic function and cardiac output. Current inotropes such as dobutamine, can promote arrhythmias, prompting a demand for improved inotropes with little effect on intracellular Ca2+ flux. Low‐dose carbon...