Estrogen Promotes Endometrial Cancer Development by Modulating ZNF626, SLK, and RFWD3 Gene Expression and Inducing Immune Inflammatory Changes

• Published in: Biomedicines Vol. 13; no. 2; p. 498
• Main Authors: Fan, Jiuming, Zhang, Mengyao, Wu, Huailiang, Ye, Zehua, Wang, Liyan
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.02.2025; MDPI
• Subjects: 17β-Estradiol; Analysis; Apoptosis; B cells; Bioinformatics; bioinformatics analysis; Cancer; Care and treatment; CD4 antigen; Cell cycle; Cell proliferation; Datasets; Down-regulation; Endometrial cancer; Endometrium; Estradiol; estrogen; Estrogen receptors; Estrogens; Flow cytometry; Gene expression; gene expression omnibus; Genes; Genetic aspects; immune cell; Immunological memory; Immunotherapy; Infiltration; Inflammation; Lymphocytes B; Lymphocytes T; Macrophages; Memory cells; mendelian randomization; Metastases; Phenols; Phenotypes; Plasma cells; T cells; Tumor microenvironment; Tumors; Uterine cancer; Variance analysis; Western blotting; Japan; China; United States > US; gene expression omnibus; endometrial cancer; immune cell; estrogen; bioinformatics analysis; mendelian randomization

: Elevated estrogen has been found to contribute to the pathological development of endometrial cancer (EC), potentially through alterations in the tumor inflammatory immune microenvironment. However, the exact mechanisms underlying this process remain unclear. : Bioinformatics was used to identify...