Epinephrine stimulates CXCL1 IL‐1α, IL‐6 secretion in isolated mouse limb muscle

• Published in: Physiological reports Vol. 5; no. 23
• Main Authors: Mattingly, Alex J., Laitano, Orlando, Clanton, Thomas L.
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.12.2017; John Wiley and Sons Inc; Wiley
• Subjects: Animal models; Animals; Catecholamines; Chelating agents; Chemokine CXCL1 - metabolism; Cytokines; Deferoxamine; Deferoxamine - pharmacology; Epinephrine; Epinephrine - pharmacology; IL‐1alpha; Immunology; Injury, Stress and Fatigue; Interleukin 1; Interleukin 6; Interleukin-1alpha - metabolism; Interleukin-6 - metabolism; keratinocyte chemoattractant; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal - drug effects; Muscle, Skeletal - metabolism; Musculoskeletal system; myokine; Norepinephrine; Norepinephrine - pharmacology; Original Research; Oxidation; Physiology; Rodents; Skeletal Muscle; stress; St Louis Missouri; United States > US; myokine; stress; epinephrine; keratinocyte chemoattractant; IL‐1alpha; Deferoxamine

Catecholamines stimulate interleukin‐6 (IL‐6) secretion in skeletal muscles. However, whether other cytokines are secreted is currently unknown. Skeletal muscle ex vivo preparations commonly used to study cytokine secretion have dealt with limitations including auto‐oxidation of catecholamines. The...