Self-Assembled Protein-Polymer Nanoparticles via Photoinitiated Polymerization-Induced Self-Assembly for Targeted and Enhanced Drug Delivery in Cancer Therapy

• Published in: Molecules (Basel, Switzerland) Vol. 30; no. 4; p. 856
• Main Authors: Ediriweera, Gayathri R, Chang, Yixin, Yang, Wenting, Whittaker, Andrew K, Fu, Changkui
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.02.2025; MDPI
• Subjects: Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Aqueous solutions; Biomedical engineering; Cancer; Cancer therapies; cancer therapy; Cell death; Cell Line, Tumor; Chemical bonds; Curcumin - chemistry; Curcumin - pharmacology; Drug Carriers - chemistry; drug delivery; Drug Delivery Systems; Drug Liberation; Drug therapy; Drugs; Endocytosis; Health aspects; Humans; Molecular weight; Morphology; Nanoparticles; Nanoparticles - chemistry; Neoplasms - drug therapy; Oncology, Experimental; photo-PISA; Polymerization; Polymers; Polymers - chemistry; protein-polymer nanoparticles; Proteins; Transferrin - chemistry; Vehicles; Italy; cancer therapy; drug delivery; photo-PISA; protein-polymer nanoparticles

Protein-polymer bioconjugates offer numerous advantages in biomedical applications by integrating the benefits of functional proteins and tunable synthetic polymers. Developing drug-loaded protein-polymer nanoparticles, with a receptor-targeting protein forming the nanoparticle shell, would be ideal...