Mesenchymal Stem Cell-Based Therapies for Temporomandibular Joint Repair: A Systematic Review of Preclinical Studies

• Published in: Cells (Basel, Switzerland) Vol. 13; no. 11; p. 990
• Main Authors: Jiang, Yuanyuan, Shi, Jiajun, Di, Wenjun, Teo, Kristeen Ye Wen, Toh, Wei Seong
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.06.2024; MDPI
• Subjects: Animal models; Animals; Arthritis; Bias; Bone marrow; Cartilage; Cartilage diseases; Cell migration; Citation management software; Disease Models, Animal; exosomes; extracellular vesicles; Extracellular Vesicles - metabolism; Extracellular Vesicles - transplantation; Humans; Immunomodulation; Laboratory animals; Mastication; Mesenchymal Stem Cell Transplantation - methods; Mesenchymal stem cells; Mesenchymal Stem Cells - cytology; mesenchymal stem/stromal cells; Muscles; Osteoarthritis; Osteoarthritis - pathology; Osteoarthritis - therapy; Quality control; Secretome; Stem cells; Systematic Review; Temporomandibular joint; Temporomandibular Joint - pathology; Temporomandibular joint disorders; Temporomandibular Joint Disorders - therapy; Transplantation; Singapore; extracellular vesicles; temporomandibular joint; exosomes; osteoarthritis; cartilage; mesenchymal stem/stromal cells; secretome; systematic review

Temporomandibular disorders (TMDs) are a heterogeneous group of musculoskeletal and neuromuscular conditions involving the temporomandibular joint (TMJ), masticatory muscles, and associated structures. Mesenchymal stromal/stem cells (MSCs) have emerged as a promising therapy for TMJ repair. This sys...