Involvement of Matricellular Proteins in Cellular Senescence: Potential Therapeutic Targets for Age-Related Diseases

• Published in: International journal of molecular sciences Vol. 25; no. 12; p. 6591
• Main Authors: Fujita, Motomichi, Sasada, Manabu, Iyoda, Takuya, Fukai, Fumio
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 15.06.2024; MDPI
• Subjects: Age; Aging; Aging - metabolism; Animals; Apoptosis; Atherosclerosis; Atherosclerosis - metabolism; Atherosclerosis - pathology; Cartilage; Cell Adhesion; Cell adhesion & migration; Cellular Senescence; communication network factor; Communications networks; Disease; Diseases; Extracellular matrix; Extracellular Matrix - metabolism; Extracellular Matrix Proteins - metabolism; Fibroblasts; Fibrosis; Growth factors; Health aspects; Humans; Integrins; Integrins - metabolism; Intervertebral Disc Degeneration - metabolism; Intervertebral Disc Degeneration - pathology; Japan; Kinases; matricryptic site; matricryptins; Molecular Targeted Therapy; Morphology; Neoplasms - drug therapy; Neoplasms - metabolism; Neoplasms - pathology; Osteoarthritis; Osteoarthritis - metabolism; Osteoarthritis - pathology; Oxidative stress; Pathology; Peptides; Physiological aspects; Physiology; Proteins; Review; Roles; Senescence; senescence-associated secretory phenotype; senomorphic drug; senotherapy; Signal Transduction; Japan; matricryptic site; matricryptins; senomorphic drug; periostin; osteopontin; PAI-1; senotherapy; tenascin-C; communication network factor; senescence-associated secretory phenotype

Senescence is a physiological and pathological cellular program triggered by various types of cellular stress. Senescent cells exhibit multiple characteristic changes. Among them, the characteristic flattened and enlarged morphology exhibited in senescent cells is observed regardless of the stimuli...