Use of dutasteride in carcinoma prostate
Summary This is a multi-centric randomized, placebo controlled trial with 294 patients with a rising prostate specific antigen (PSA), following radical radiotherapy (RT), radical prostatectomy (RP) with or without salvage radiotherapy, or primary radiotherapy alone for clinically localized prostate...
Saved in:
| Published in | Indian journal of urology Vol. 30; no. 1; pp. 123 - 124 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
Vellore
Medknow Publications
01.01.2014
Medknow Publications and Media Pvt. Ltd Medknow Publications & Media Pvt. Ltd Wolters Kluwer Medknow Publications |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Summary This is a multi-centric randomized, placebo controlled trial with 294 patients with a rising prostate specific antigen (PSA), following radical radiotherapy (RT), radical prostatectomy (RP) with or without salvage radiotherapy, or primary radiotherapy alone for clinically localized prostate carcinoma (PCa) with curative intent, being randomized 1:1 between placebo and dutasteride 0.5 mg once daily for 2 year. Another significant finding noted was the lower incidence of disease progression in the dutasteride group (17%; 25 of 146) compared with the placebo (34%; 49 of 144) in terms of incidence of PSA related progression like PSADT < 3 mo, Absolute high PSA and clinical progression such as positive biopsy, bone metastasis and the need for rescue therapy like anti-androgens or luteinizing hormone-releasing hormone therapy. |
|---|---|
| AbstractList | Summary This is a multi-centric randomized, placebo controlled trial with 294 patients with a rising prostate specific antigen (PSA), following radical radiotherapy (RT), radical prostatectomy (RP) with or without salvage radiotherapy, or primary radiotherapy alone for clinically localized prostate carcinoma (PCa) with curative intent, being randomized 1:1 between placebo and dutasteride 0.5 mg once daily for 2 year. Another significant finding noted was the lower incidence of disease progression in the dutasteride group (17%; 25 of 146) compared with the placebo (34%; 49 of 144) in terms of incidence of PSA related progression like PSADT < 3 mo, Absolute high PSA and clinical progression such as positive biopsy, bone metastasis and the need for rescue therapy like anti-androgens or luteinizing hormone-releasing hormone therapy. |
| Audience | Academic |
| Author | Shrinivas, R |
| Author_xml | – sequence: 1 givenname: R surname: Shrinivas fullname: Shrinivas, R organization: , |
| BookMark | eNptkU1rHDEMhk1JoZtt_8NALr1Mkb_tYwhpGwj00pyN1h-LNzPjxJ5lyb-v6baUwiKBQDx6kfRek6ulLPEd2VBrzcgNE1dkA1bDSKWlH8h1awcAQQ1TG_L5qcWhpCEcV2xrrDnEIS-Dx-rzUmYcXmppK67xI3mfcGrx05-6JU9f73_efR8ff3x7uLt9HAO3so7eJ6uNFRiY5wEZAFMKNdfWg7FJCyOjTELKpJRJQQi10wAcGCiUO035ljycdUPBg3upecb65gpm97tR6t5hXbOfogNQhsqIO0mNCCEZ0F7rZBlTkvOeW3Jz1upHvB5jW92hHOvS13dUUtERsPCP2mMXzUsqa0U_5-bdLVeCa0qF6dR4gdrHJVac-r9T7u3_-C8X-B4hztlfHIDzwKlM3Yj2PB1Psbo5huelnBxl3HWvXEnur1f8F13Pk2c |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2014 Medknow Publications and Media Pvt. Ltd. Copyright Medknow Publications & Media Pvt Ltd Jan-Mar 2014 |
| Copyright_xml | – notice: COPYRIGHT 2014 Medknow Publications and Media Pvt. Ltd. – notice: Copyright Medknow Publications & Media Pvt Ltd Jan-Mar 2014 |
| DBID | 3V. 7X7 7XB 8FI 8FJ 8FK 8G5 ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH GNUQQ GUQSH K9. M0S M2O MBDVC PADUT PIMPY PQEST PQQKQ PQUKI PRINS Q9U DOA |
| DatabaseName | ProQuest Central (Corporate) ProQuest Health & Medical Collection ProQuest Central (purchase pre-March 2016) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni Edition) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Research Library Prep ProQuest Health & Medical Complete (Alumni) Health & Medical Collection (Alumni Edition) ProQuest Research Library Research Library (Corporate) Research Library China Publicly Available Content Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic DOAJ Directory of Open Access Journals |
| DatabaseTitle | Publicly Available Content Database Research Library Prep ProQuest Central Student ProQuest Central Basic ProQuest Central Essentials ProQuest One Academic Eastern Edition ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest Hospital Collection Research Library (Alumni Edition) Health Research Premium Collection (Alumni) ProQuest Central China ProQuest Hospital Collection (Alumni) ProQuest Central ProQuest Health & Medical Complete Health Research Premium Collection ProQuest One Academic UKI Edition Health and Medicine Complete (Alumni Edition) ProQuest Central Korea ProQuest Research Library Research Library China ProQuest One Academic ProQuest Central (Alumni) |
| DatabaseTitleList | Publicly Available Content Database |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1998-3824 |
| EndPage | 124 |
| ExternalDocumentID | oai_doaj_org_article_006815eab5184ddf807c77f922653353 3271295501 A364371148 123_Use of dutaster |
| GeographicLocations | India |
| GeographicLocations_xml | – name: India |
| GroupedDBID | - 04C 29I 2WC 3V. 53G 5GY 7X7 8FI 8FJ 8G5 AAWTL ABUWG ACGFS ADACO ADRAZ AFKRA AHMBA ALMA_UNASSIGNED_HOLDINGS AZQEC BBAFP BENPR BPHCQ BVXVI DIK DU5 DWQXO E3Z EBD EBS EJD F5P FYUFA GNUQQ GROUPED_DOAJ GUQSH GX1 H13 HYE IAO IEA IHE IHR IOF ITC KQ8 LI0 M2O M48 MBDVC M~E O5R O5S OBODZ OK1 P2P PADUT PIMPY PQEST PQQKQ PQUKI PRINS PROAC RIG RMW RPM --- ABJNI ABXLX ADFRT CCPQU EIHBH EOJEC HMCUK IPNFZ OVD TEORI UKHRP W3E 7XB 8FK ALIPV K9. PGMZT Q9U |
| ID | FETCH-LOGICAL-d395r-ccf97894ad2c3da200266a7379c089f7485e5f455f668fd446b70030206a5b713 |
| IEDL.DBID | DOA |
| ISSN | 0970-1591 |
| IngestDate | Fri Oct 04 13:14:29 EDT 2024 Thu Oct 10 21:11:38 EDT 2024 Thu Feb 22 23:41:12 EST 2024 Wed Dec 27 15:31:06 EST 2023 Sat Dec 16 00:17:45 EST 2023 Tue Jan 05 18:31:35 EST 2021 |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-d395r-ccf97894ad2c3da200266a7379c089f7485e5f455f668fd446b70030206a5b713 |
| OpenAccessLink | https://doaj.org/article/006815eab5184ddf807c77f922653353 |
| PQID | 1514353090 |
| PQPubID | 226502 |
| PageCount | 2 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_006815eab5184ddf807c77f922653353 proquest_journals_1514353090 gale_infotracmisc_A364371148 gale_infotracgeneralonefile_A364371148 gale_infotracacademiconefile_A364371148 wolterskluwer_medknow_123_Use_of_dutaster |
| ProviderPackageCode | RMW |
| PublicationCentury | 2000 |
| PublicationDate | 20140101 2014-01-01 |
| PublicationDateYYYYMMDD | 2014-01-01 |
| PublicationDate_xml | – month: 1 year: 2014 text: 20140101 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Vellore |
| PublicationPlace_xml | – name: Vellore |
| PublicationTitle | Indian journal of urology |
| PublicationYear | 2014 |
| Publisher | Medknow Publications Medknow Publications and Media Pvt. Ltd Medknow Publications & Media Pvt. Ltd Wolters Kluwer Medknow Publications |
| Publisher_xml | – name: Medknow Publications – name: Medknow Publications and Media Pvt. Ltd – name: Medknow Publications & Media Pvt. Ltd – name: Wolters Kluwer Medknow Publications |
| SSID | ssj0041826 |
| Score | 1.9664454 |
| Snippet | Summary This is a multi-centric randomized, placebo controlled trial with 294 patients with a rising prostate specific antigen (PSA), following radical... |
| SourceID | doaj proquest gale wolterskluwer |
| SourceType | Open Website Aggregation Database Publisher |
| StartPage | 123 |
| SubjectTerms | Diagnosis Drug therapy Dutasteride Health aspects Medical research Prostate cancer Prostate-specific antigen Radiation therapy |
| SummonAdditionalLinks | – databaseName: ProQuest Central dbid: BENPR link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1JS-xAEC5cQHyIuPLGjRzE5dCYrdPpk6goIigiDnhrOr2IiMm8mXn4961KetBB8Zo0IXRtX3VVfwWwr03qRalLJrTOWM65ZVoKzqSphPepTFxL4np7V1z385sn_hQO3EahrXLiE1tHbRtDZ-QnSRvZs1jGp4N_jKZGUXU1jNCYhfk0yalMO39-eXf_MPHFOaHnlm1PxAwDdxKY-b_73z-w9N5QfXr02ranfwkyVyuwHNBhdNaJcxVmXL0GC7eh_r0OR_2RixofWeqkJpZl66KXOjI0EKhu3nQ0oEscCB83oH91-XhxzcKsA2YzyYfMGI_5nMy1TU1mNbVOFIUWmZAmLqUXeckd97iXvihKbzGJqwQZaBoXmleYaW7CXN3U7i9EmAJkppBpTMzxRuQyNabihUvQ2mKdVD04pz1Qg47OQhHBdPugGT6roK-Kro4k3OmKYwporS9jYYTwEtEaAkSe9eCQdlCRGYyH2ujQzY-_QIRS6iyjiiAlWz04mFr53NFp_7RwZ2oh6rmZfj0Rlgp2NlKfWtGD4ykBqrfuOqHC0KxQOKrxaiKcrd8_tQ2LCIvy7qBlB-bGw_9uF6HHuNoL-vUBAjXZBw priority: 102 providerName: ProQuest – databaseName: Medknow Medical Journals (Open access) dbid: W3E link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1La9wwEB5CCqGllDRt6aZp8aGk7cEgW5ZlYXpIS0IIpJdkITch65G-YgfvbkP-fWdkLXRpL70Ze8CS5qEZzcwngLfGlkE2psmlMTyvhHC5UVLkynYyhFIVPoK4nn-pT-fV2ZW42oJ11RJVVVKu1vTfV-PwM5rqtISxsSsdXUmW4zZctPcoDXTKV7VJlzlr03jbSSHRMLc-PVWtWaFLuvx48ZWyI7_Moo3IRBjxPygJhYUaUvjx2pBX5HpHqL70uwTr_7fxfgSP7wZKbi9-xNr2P3aok114klzL7GiayFPY8v0e7Jyn5PkzeD9f-GwImaMybIJodj771meWbhPqhxuT3VIHCPqez2F-cnz5-TRPFyXkjisx5tYGDAZVZVxpuTNUd1HXRnKpLGtUwKkJLwIyItR1ExxGgJ0k7S5ZbUSHYeoL2O6H3r-EDOMHbmtVMoKdt7JSpbWdqH2BqspM0c3gE62Bvp2wMDShU8cXw3itE6c09Z0UwptOYPzoXGiYtFIGha4eepeCz-AdraAmHVqOxprUCoBDIDQqfcQpnUiR2gwONyivJyzufxEebBCiktjNz2tm6aSkC11EZ5EzxWbwYYOB-mbqRdQoPhqZo4eg18zZ_w_aV_CQpHM6sjmA7eW48q_RiVl2b6Ko_QbWV_O9 priority: 102 providerName: Wolters Kluwer Health |
| Title | Use of dutasteride in carcinoma prostate |
| URI | http://www.indianjurol.com/article.asp?issn=0970-1591;year=2014;volume=30;issue=1;spage=123;epage=124;aulast=Shrinivas;type=0 https://www.proquest.com/docview/1514353090 https://doaj.org/article/006815eab5184ddf807c77f922653353 |
| Volume | 30 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LS8QwEB58gCgiPnF9LD2Ij0OxrzTNUWVFhBURF_cW0jxExFZ2V_z7zjRdcFHw4iWHdA7hmyTzTTP5AnCkdOJ4oYqQK5WGGWMmVIKzUOiSO5eI2DYirv27_GaQ3Q7Z8NtTX1QT5uWBPXDndIchZlaVDHMRY1wRcc25E0gbkKkwr_MZs2ky5ffgjFhzo7LHoxADdtwq8v_cd1dg9bOmc-nxa1OW_i24XK_DWssKgws_mg2Ys9UmLPXbc-8tOB2MbVC7wFAFNakrGxu8VIGmh4Cq-k0F73R5A2njNgyue49XN2H7xkFoUsFGodYO8ziRKZPo1CgqmchzxVMudFQIx7OCWeYQQ5fnhTOYvJWcFmYS5YqVmGHuwEJVV3YXAqT-qc5FEpFivOaZSLQuWW5jXGWRissOXBIG8t3LWEgSlm46EG7Zwi3_grsDJ4SgpOk_GSmt2ip-HAIJScmLlE4CKcnqwPGM5bOX0f7N8GDGEOe3nv08dZZs19dYxg3PSyMRdeBsxoHyzV8jlBiSJTpH1k5OnbP3HwjswzKSpsz_hjmAhcnowx4iMZmUXZjnQ96Fxcve3f1Dt5mR2PazAtuntPcFvUDjKg |
| link.rule.ids | 315,786,790,2115,2236,12083,21416,27489,31752,33777,43343,43838,74100,74657 |
| linkProvider | Directory of Open Access Journals |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dS9xAEB_aE6yllPpFz9o2D6Xqw2K-Npt9Ei3KtfWOUjzwbdnsxyFicr076b_vTLJHPZS-JksIO1-_2Zn9DcAXbVIvSl0yoXXGcs4t01JwJk0lvE9l4loS1-GoGIzzH9f8Ohy4zUNb5dInto7aNobOyI-TNrJnsYxPpn8YTY2i6moYofES1ohys-zB2tn56NfvpS_OCT23bHsiZhi4k8DM_9T_voY3fxuqT89v2_b0R0Hm4h28DegwOu3EuQkvXL0F68NQ_96Gw_HcRY2PLHVSE8uyddFNHRkaCFQ3dzqa0iUOhI87ML44v_o2YGHWAbOZ5DNmjMd8TubapiazmlonikKLTEgTl9KLvOSOe9xLXxSlt5jEVYIMNI0LzSvMNHehVze1ew8RpgCZKWQaE3O8EblMjal44RK0tlgnVR_OaA_UtKOzUEQw3T5oZhMV9FXR1ZGEO11xTAGt9WUsjBBeIlpDgMizPhzQDioyg8VMGx26-fEXiFBKnWZUEaRkqw9fV1ZOOjrt5xburyxEPTerr5fCUsHO5uqfVvThaEWA6q67TqgwNCsUjmq8Wgpn7_-f-gyvBlfDS3X5ffTzA2wgRMq7Q5d96C1m9-4jwpBF9Sno2gNsUdv9 |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LT9wwEB4VKqFWCPUB6vJoc0B9HKx1Ho7jEwLaFW0BcehKe7McP1BVkWx3t-rfZybxQldUXBMrijwznm88M98AHBqbBVmZikljclYI4ZhRUjBlaxlCplLfkbheXJZn4-LbRExi_dM8llUuz8TuoHatpTvyYdp59pwrPgyxLOLq8-ho-pvRBCnKtMZxGmvwFL0kpzEOcnIXfBWEozvePckZuvA0cvQ_PImfw-bfljLV819dofo_7mb0ArYiTkyOe8G-hCe-eQUbFzET_ho-juc-aUPiqKaa-JadT342iaXRQE17Y5IptXMgkNyG8ejLj9MzFqceMJcrMWPWBozsVGFcZnNnqIiiLI3MpbK8UkEWlfAi4K6GsqyCw3CulmSqGS-NqDHm3IH1pm38G0gwGMhtqTJOHPJWFiqzthalT9HuuEnrAZzQHuhpT2yhiWq6e9DOrnXUXE1NJKnwphYYDDoXKi6tlEEhbkOoKPIBfKAd1GQQi5mxJtb14y8QtZQ-zik3SGHXAN6vrLzuibX_t3B_ZSFqvF19vRSWjhY31_f6MYBPKwLUN31joUYnrVE4ug16KZzdxz_1DjZQyfT518vve_AMsVLR377sw_pi9scfIB5Z1G87RbsFsLLeug |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Use+of+dutasteride+in+carcinoma+prostate&rft.jtitle=Indian+journal+of+urology&rft.au=R+P+Shrinivas&rft.date=2014-01-01&rft.pub=Wolters+Kluwer+Medknow+Publications&rft.issn=0970-1591&rft.eissn=1998-3824&rft.volume=30&rft.issue=1&rft.spage=123&rft.epage=124&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_006815eab5184ddf807c77f922653353 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0970-1591&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0970-1591&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0970-1591&client=summon |