The spatiotemporal transcriptional profiling of murine brain during cerebral malaria progression and after artemisinin treatment - Chen, Jiayun; Bai, Yunmeng; He, Xueling; Xiao, Wei; Chen, Lina; Wong, Yin Kwan; Wang, Chen; Gao, Peng; Cheng, Guangqing; Xu, Liting; Yang, Chuanbin; Liao, Fulong; et al. (Nature communications, 2025)
Keywords: 38/39; 45/91; 49; 49/105; 631/114/2401; 631/61/212/2019; 64/60; 692/699/255/1715; Animals; Antigen presentation; Antigens; Antimalarial agents; Antimalarials - pharmacology; Antimalarials - therapeutic use; Artemisinin; Artemisinins - pharmacology; Artemisinins - therapeutic use; Artesunate; Artesunate - pharmacology; Artesunate - therapeutic use; Blood parasites; Blood-brain barrier; Blood-Brain Barrier - drug effects; Blood-Brain Barrier - metabolism; Brain - drug effects; Brain - metabolism; Brain - parasitology; Brain - pathology; CD8 antigen; Complications; Cytotoxicity; Disease Models, Animal; Disease Progression; Encephalopathy; Endothelial cells; Endothelial Cells - drug effects; Endothelial Cells - metabolism; Extracellular matrix; Gene Expression Profiling; Host-Parasite Interactions; Humanities and Social Sciences; Inflammation; Injury analysis; Interferon-gamma - metabolism; Lymphocytes; Lymphocytes T; Major histocompatibility complex; Malaria; Malaria, Cerebral - drug therapy; Malaria, Cerebral - genetics; Malaria, Cerebral - immunology; Malaria, Cerebral - parasitology; Malaria, Cerebral - pathology; Male; Mice; Mice, Inbred C57BL; Microglia; Microglia - drug effects; Microglia - metabolism; multidisciplinary; Parasites; Science; Science (multidisciplinary); Spatial analysis; Transcriptome; Transcriptomes; Transcriptomics; Vector-borne diseases; γ-Interferon