Establishment and verification of a TME prognosis scoring model based on the acute myeloid leukemia single-cell transcriptome

• Published in: Scientific reports Vol. 14; no. 1; pp. 19811 - 11
• Main Authors: Miao, Peiwen, Yu, Jingdi, Chen, Zhenzhen, Qian, Shenxian, Chen, Can
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 27.08.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 692/308; 692/4028; Acute myeloid leukemia; Acute Myeloid Leukemia (AML); Biomarkers, Tumor - genetics; Bone marrow; Cell culture; Chemokine CCL5 - genetics; Chemokine CCL5 - metabolism; Drug resistance; Ets-2 protein; Female; Heterogeneity; Humanities and Social Sciences; Humans; Interleukin 2 receptors; Leukemia; Leukemia, Myeloid, Acute - genetics; Leukemia, Myeloid, Acute - mortality; Leukemia, Myeloid, Acute - pathology; Male; Medical prognosis; Metastases; Middle Aged; multidisciplinary; Prognosis; Proto-Oncogene Protein c-ets-2; Risk groups; Science; Science (multidisciplinary); Single-Cell Analysis - methods; Single-cell sequencing; Transcriptome; Transcriptomes; Tumor cells; Tumor microenvironment; Tumor Microenvironment - genetics; Tumor Microenvironment - immunology; Tumors; Heterogeneity; Single-cell sequencing; Prognosis; Tumor microenvironment; Acute Myeloid Leukemia (AML)

The tumor microenvironment (TME) plays an important role in the occurrence and progression of Acute Myeloid Leukemia (AML). Single-cell sequencing has enabled researchers to explore the correlation between TME subgroups and tumor prognosis, distinguish the existence of drug-resistant subgroups of tu...