Recent advances in transition metal-catalyzed Csp2-monofluoro-, difluoro-, perfluoromethylation and trifluoromethylthiolation

• Published in: Beilstein journal of organic chemistry Vol. 9; no. 1; pp. 2476 - 2536
• Main Authors: Landelle, Grégory, Panossian, Armen, Pazenok, Sergiy, Vors, Jean-Pierre, Leroux, Frédéric R
• Format: Journal Article
• Language: English
• Published: Trakehner Str. 7-9, 60487 Frankfurt am Main, Germany Beilstein-Institut 15.11.2013
• Subjects: catalysis; Chemistry; cross-coupling; difluoromethylation; fluorine; monofluoromethylation; organo-fluorine; Review; transition metal; trifluoromethylation; trifluoromethylthiolation

In the last few years, transition metal-mediated reactions have joined the toolbox of chemists working in the field of fluorination for Life-Science oriented research. The successful execution of transition metal-catalyzed carbon–fluorine bond formation has become a landmark achievement in fluorine...