Recent advances in transition metal-catalyzed Csp2-monofluoro-, difluoro-, perfluoromethylation and trifluoromethylthiolation

In the last few years, transition metal-mediated reactions have joined the toolbox of chemists working in the field of fluorination for Life-Science oriented research. The successful execution of transition metal-catalyzed carbon–fluorine bond formation has become a landmark achievement in fluorine...

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Published inBeilstein journal of organic chemistry Vol. 9; no. 1; pp. 2476 - 2536
Main Authors Landelle, Grégory, Panossian, Armen, Pazenok, Sergiy, Vors, Jean-Pierre, Leroux, Frédéric R
Format Journal Article
LanguageEnglish
Published Trakehner Str. 7-9, 60487 Frankfurt am Main, Germany Beilstein-Institut 15.11.2013
Subjects
catalysis
Chemistry
cross-coupling
difluoromethylation
fluorine
monofluoromethylation
organo-fluorine
Review
transition metal
trifluoromethylation
trifluoromethylthiolation
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Summary:In the last few years, transition metal-mediated reactions have joined the toolbox of chemists working in the field of fluorination for Life-Science oriented research. The successful execution of transition metal-catalyzed carbon–fluorine bond formation has become a landmark achievement in fluorine chemistry. This rapidly growing research field has been the subject of some excellent reviews. Our approach focuses exclusively on transition metal-catalyzed reactions that allow the introduction of –CFH 2 , –CF 2 H, –C n F 2 n +1 and –SCF 3 groups onto sp² carbon atoms. Transformations are discussed according to the reaction-type and the metal employed. The review will not extend to conventional non-transition metal methods to these fluorinated groups.
Bibliography:http://www.syncat.org
ISSN:1860-5397
1860-5397
DOI:10.3762/bjoc.9.287