Proximity extension assay revealed novel inflammatory biomarkers for follicular development and ovarian function: a prospective controlled study combining serum and follicular fluid

• Published in: Frontiers in endocrinology (Lausanne) Vol. 16; p. 1525392
• Main Authors: Wang, Chong, Feng, Ying, Chen, Yu, Lin, Xianhua, Li, Xiangjuan
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 2025
• Subjects: Adult; Biomarkers - analysis; Biomarkers - blood; Biomarkers - metabolism; Endocrinology; Female; follicular development; follicular fluid; Follicular Fluid - metabolism; Humans; Inflammation - blood; Inflammation - metabolism; Ovarian Follicle - growth & development; Ovarian Follicle - metabolism; Ovarian Follicle - physiology; ovarian function; Ovarian Reserve - physiology; Ovary - metabolism; Ovary - physiology; Prospective Studies; Proteomics - methods; proximity extension assay; serum; Young Adult; follicular development; proximity extension assay; serum; ovarian function; follicular fluid

Many components in follicular fluid (FF), such as peptide hormones, cytokines, and steroids, undergo dynamic changes during folliculogenesis and have important roles in follicular development. Because systemic inflammation has also been found to contribute to diminished ovarian reserve (DOR) in prev...