Clinical characteristics and prognosis of ALL in children with CDKN2A/B gene deletion

• Published in: Experimental biology and medicine (Maywood, N.J.) Vol. 250; p. 10447
• Main Authors: Wang, Yiyu, Wu, Peijing, Mao, Xiaoyan, Jiang, Nanjing, Huang, Yu, Zhang, Li, Liu, Li, Tian, Xin
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 2025
• Subjects: acute lymphoblastic leukemia; Adolescent; CDKN2A/B gene; Child; Child, Preschool; children; clinical characteristics; Cyclin-Dependent Kinase Inhibitor p15 - genetics; Cyclin-Dependent Kinase Inhibitor p16 - genetics; Experimental Biology and Medicine; Female; Gene Deletion; Humans; Infant; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality; Prognosis; survival analysis; CDKN2A/B gene; survival analysis; acute lymphoblastic leukemia; children; clinical characteristics

This study aimed to explore the correlation between the deletion of the CDKN2A/B gene and the prognosis of pediatric acute lymphoblastic leukemia (ALL) patients. A total of 310 pediatric patients who were diagnosed with acute lymphoblastic leukemia at our hospital from January 2020 to September 2023...