Formononetin and Dihydroartemisinin Act Synergistically to Induce Apoptosis in Human Acute Myeloid Leukemia Cell Lines

• Published in: Cell journal (Yakhteh) Vol. 26; no. 2; pp. 121 - 129
• Main Authors: Abbasi, Yusef, Pooladi, Marziyeh, Nazmabadi, Roya, Amri, Jamal, Abbasi, Helia, Karami, Hadi
• Format: Journal Article
• Language: English
• Published: Iran Royan Institute of Iran 01.02.2024; Royan Institute; Royan Institute (ACECR), Tehran
• Subjects: Acute myeloid leukemia; Anticancer properties; Antineoplastic drugs; Apoptosis; BAX protein; bcl-2; Bcl-2 protein; Caspase-3; Cell cycle; Cell proliferation; Cell survival; Chemotherapy; Colorimetry; Cyclin D1; Dihydroartemisinin; Drug resistance; formononetin; Gene expression; Leukemia; mcl-1; Mcl-1 protein; mRNA; Original; Polymerase chain reaction; Staining; Survival; Tumor cell lines; Tumor cells; Bcl-2; Dihydroartemisinin; Mcl-1; Acute Myeloid Leukemia; Formononetin; Apoptosis

Enhanced cell survival and drug resistance in tumor cells have been linked to the overexpression of antiapoptotic members of the Bcl-2 family proteins, including Bcl-2 and Mcl-1. The aim of this study was to explore the impact of formononetin and dihydroartemisinin combination on the growth and apop...