Ethanol metabolism and oxidative stress are required for unfolded protein response activation and steatosis in zebrafish with alcoholic liver disease

• Published in: Disease models & mechanisms Vol. 6; no. 5; pp. 1213 - 1226
• Main Authors: Tsedensodnom, Orkhontuya, Vacaru, Ana M, Howarth, Deanna L, Yin, Chunyue, Sadler, Kirsten C
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Ltd 01.09.2013; The Company of Biologists Limited; The Company of Biologists
• Subjects: Alcohol Dehydrogenase - metabolism; Alcoholism; Animals; Antioxidants - pharmacology; Cytochrome P-450 CYP2E1 - metabolism; Endoplasmic Reticulum Stress - drug effects; Enzymes; Ethanol; Ethanol - metabolism; Ethanol - toxicity; Fatty Liver - complications; Fatty Liver - metabolism; Gene expression; Hepatic Stellate Cells - drug effects; Hepatic Stellate Cells - metabolism; Hepatic Stellate Cells - pathology; Hypotheses; Larva - drug effects; Larva - metabolism; Lipids; Liver - drug effects; Liver - metabolism; Liver - pathology; Liver diseases; Liver Diseases, Alcoholic - complications; Liver Diseases, Alcoholic - metabolism; Mammals; Metabolism; Oxidative stress; Oxidative Stress - drug effects; Pathophysiology; Proteins; Reactive oxygen species; Reactive Oxygen Species - metabolism; Secretory Pathway - drug effects; Survival Analysis; Unfolded Protein Response - drug effects; Vertebrates; Zebrafish - metabolism; United States > US

Secretory pathway dysfunction and lipid accumulation (steatosis) are the two most common responses of hepatocytes to ethanol exposure and are major factors in the pathophysiology of alcoholic liver disease (ALD). However, the mechanisms by which ethanol elicits these cellular responses are not fully...