Ethanol metabolism and oxidative stress are required for unfolded protein response activation and steatosis in zebrafish with alcoholic liver disease - Tsedensodnom, Orkhontuya; Vacaru, Ana M; Howarth, Deanna L; Yin, Chunyue; Sadler, Kirsten C (Disease models & mechanisms, 2013)
Keywords: Alcohol Dehydrogenase - metabolism; Alcoholism; Animals; Antioxidants - pharmacology; Cytochrome P-450 CYP2E1 - metabolism; Endoplasmic Reticulum Stress - drug effects; Enzymes; Ethanol; Ethanol - metabolism; Ethanol - toxicity; Fatty Liver - complications; Fatty Liver - metabolism; Gene expression; Hepatic Stellate Cells - drug effects; Hepatic Stellate Cells - metabolism; Hepatic Stellate Cells - pathology; Hypotheses; Larva - drug effects; Larva - metabolism; Lipids; Liver - drug effects; Liver - metabolism; Liver - pathology; Liver diseases; Liver Diseases, Alcoholic - complications; Liver Diseases, Alcoholic - metabolism; Mammals; Metabolism; Oxidative stress; Oxidative Stress - drug effects; Pathophysiology; Proteins; Reactive oxygen species; Reactive Oxygen Species - metabolism; Secretory Pathway - drug effects; Survival Analysis; Unfolded Protein Response - drug effects; Vertebrates; Zebrafish - metabolism; United States--US