An overview of pharmacological activities of baicalin and its aglycone baicalein: New insights into molecular mechanisms and signaling pathways

• Published in: Iranian journal of basic medical sciences Vol. 25; no. 1; pp. 14 - 26
• Main Authors: Hu, Zhihua, Guan, Yurong, Hu, Wanying, Xu, Zhiyong, Ishfaq, Muhammad
• Format: Journal Article
• Language: English
• Published: Iran Mashhad University of Medical Sciences 01.01.2022
• Subjects: Antiviral drugs; Asthma; Atherosclerosis; baicalein; baicalin; Cancer; Cell cycle; Chemotherapy; Computer science; Cytokines; Drug dosages; Flavonoids; Hypertension; Inflammation; Inflammatory diseases; Medical imaging; Medical research; mitochondrial functions; Optimization; Proteins; Pulmonary arteries; Reactive oxygen species; Review; Rheumatoid arthritis; Smooth muscle; Therapeutic drug monitoring; Traditional Chinese medicine; Baicalein; Mitochondrial functions; Baicalin; Inflammatory diseases; Cancer

The flavonoids, baicalin, and its aglycone baicalein possess multi-fold therapeutic properties and are mainly found in the roots of (L.) Kurz and Georgi. These flavonoids have been reported to possess various pharmacological properties, including antibacterial, antiviral, anticancer, anticonvulsant,...