Synergistic Effects of Artesunate in Combination with Amphotericin B and Miltefosine against Leishmania infantum : Potential for Dose Reduction and Enhanced Therapeutic Strategies

• Published in: Antibiotics (Basel) Vol. 13; no. 9; p. 806
• Main Authors: Intakhan, Nuchpicha, Saeung, Atiporn, Rodrigues Oliveira, Sonia M, Pereira, Maria de Lourdes, Chanmol, Wetpisit
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.09.2024; MDPI
• Subjects: Amphotericin B; Analysis; Antineoplastic drugs; antiparasitic agents; Artesunate; Causes of; Chemotherapy; Dosage and administration; Dose-response relationship (Biochemistry); drug combinations; Drug development; Drug interaction; Drug interactions; Drug therapy; Drug therapy, Combination; Drugs; Infectious diseases; Leishmania infantum; Leishmaniasis; Miltefosine; Parasites; Parasitic diseases; Paromomycin; Protozoa; Side effects; Synergism; Synergistic effect; Testing; Toxicity; Vector-borne diseases; zoonosis; Thailand; drug therapy; antiparasitic agents; artesunate; leishmaniasis; zoonosis; drug combinations

Leishmaniasis is a tropical infectious disease caused by parasites. The disease can be spread by the bite of an infected sand fly. Currently, five chemotherapeutic drugs are available in leishmaniasis treatment. However, these drugs exhibit toxicity and serious adverse effects on infected individual...