Single‐cell RNA Seq reveals cellular landscape‐specific characteristics and potential etiologies for adolescent idiopathic scoliosis

• Published in: JOR-spine Vol. 4; no. 4; pp. e1184 - n/a
• Main Authors: Yang, Yilin, Yang, Mingyuan, Shi, Dongliang, Chen, Kai, Zhao, Jian, He, Shisheng, Bai, Yushu, Shen, Pinquan, Ni, Haijian
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.12.2021; Wiley
• Subjects: adolescent idiopathic scoliosis; Bar codes; Blood; Bones; differentiation; Etiology; Gene expression; Ontology; Pathogenesis; Scoliosis; single‐cell RNA sequencing; Special Issue; Stem cells; Vertebrae; differentiation; single‐cell RNA sequencing; adolescent idiopathic scoliosis; etiology

Backgrounds Abnormal vertebral growth and development have been found in adolescent idiopathic scoliosis (AIS) patients, and the proliferation and differentiation of bone development‐related cells play important roles in its pathogenesis. However, a comprehensive single‐cell‐level differentiation ro...