Comparisons of magnetic resonance imaging, histopathological and Ki-67 labeling index findings in a single myxofibrosarcoma: a case report

• Published in: Journal of medical case reports Vol. 18; no. 1; pp. 373 - 4
• Main Authors: Tsujimura, Ryusuke, Uto, Kenta, Nakano, Noriyuki, Sato, Yusuke, Kobashi, Yuko, Kojima, Toshio, Hao, Hiroyuki
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 16.08.2024; BMC
• Subjects: Cellular portions; Female; Fibrosarcoma - diagnostic imaging; Fibrosarcoma - pathology; Humans; Immunohistochemistry; Ki-67; Ki-67 Antigen - metabolism; Magnetic Resonance Imaging; Middle Aged; Myxofibrosarcoma; Myxoid portions; Sarcoma; Soft Tissue Neoplasms - diagnostic imaging; Soft Tissue Neoplasms - pathology; Tail sign; Japan; Ki-67; Myxofibrosarcoma; Myxoid portions; Tail sign; Cellular portions
• DOI: 10.1186/s13256-024-04693-y
• ISSN: 1752-1947

Myxofibrosarcoma is a myxoid soft tissue sarcoma showing T2 high intensity on magnetic resonance imaging. However, myxofibrosarcoma is a heterogeneous sarcoma with both myxoid and cellular portions. Magnetic resonance imaging findings were obtained MRI findings for comparison with histological and Ki-67 immunohistochemical features, in different portions of one myxofibrosarcoma. Magnetic resonance imaging observations were compared with gross pathological and microscopic findings of a myxofibrosarcoma from a 50-year-old Japanese female. The Ki-67 labeling indices of different portions of the tumor, that is, the myxoid, cellular, and histologically confirmed infiltrative margin portions (pathological tail sign), were compared. The T2 low intensity area was more cellular than the T2 high intensity area, while the cellular portion had a significantly higher Ki-67 index than the myxoid portion (p = 0.0313). The portions with the pathological tail sign had a significantly higher Ki-67 labeling index than those without this sign (p = 0.0313). More cellular portions of a myxofibrosarcoma correspond to more areas of the tumor showing aggressive features. Furthermore, our data also support the hypothesis of high aggressiveness being associated with the pathological tail sign in myxofibrosarcoma. To our knowledge, this is the first case report to describe comparisons among the imaging findings, histological features, and Ki-67 immunohistochemistry results for different portions of one myxofibrosarcoma.