Activation of P2X7 Receptor Mediates the Abnormal Ovulation Induced by Chronic Restraint Stress and Chronic Cold Stress

• Published in: Biology (Basel, Switzerland) Vol. 13; no. 8; p. 620
• Main Authors: Fan, Xiang, Wang, Jing, Ma, Yinyin, Chai, Dandan, Han, Suo, Xiao, Chuyu, Huang, Yingtong, Wang, Xiaojie, Wang, Jianming, Wang, Shimeng, Xiao, Li, Zhang, Chunping
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.08.2024; MDPI
• Subjects: Analysis; Animal models; Cell activation; Cell culture; chronic cold stress; chronic restraint stress; Clemastine; Cold; corpus luteum; Down-regulation; Economic indicators; Ethanol; Females; Fibrosis; Follicles; Gelatinase A; Granulosa cells; Homeostasis; Mental disorders; Mental health; Ovaries; Ovulation; P2X7R; Penicillin; Physiological aspects; Reproduction; Reproductive health; Transforming growth factor-b1; Transforming growth factors; China; United States > US

Chronic stress significantly impacts physical and mental health and has also been shown to affect female reproduction, but the underlying mechanisms are not well understood. Our research focused on the P2X7 receptor, a protein involved in the pathological response under long-term stress. Using mouse...