In Vitro and In Vivo Anti-Inflammatory and Antidepressant-like Effects of Cannabis sativa L. Extracts

• Published in: Plants (Basel) Vol. 13; no. 12; p. 1619
• Main Authors: Shin, Joonyoung, Choi, Sangheon, Park, A Yeong, Ju, Suk, Kweon, Bitna, Kim, Dong-Uk, Bae, Gi-Sang, Han, Dongwoon, Kwon, Eunjeong, Hong, Jongki, Kim, Sungchul
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 12.06.2024; MDPI
• Subjects: Analgesics; anti-inflammatory effect; Antidepressants; Behavior; Biological activity; Cannabidiol; Cannabinoids; Cannabis; Cannabis sativa; Cannabis sativa L; Caryophyllene; Chromatography; Cyclooxygenase-2; Cytokines; Degranulation; entourage effect; Field tests; Food industry; Food products; In vivo methods and tests; Interleukin 6; Leaves; lipopolysaccharide; Lipopolysaccharides; Lymph nodes; Marijuana; Mass spectrometry; Mast cells; Microglia; Microglial cells; Nitric oxide; Nitric-oxide synthase; Open-field behavior; Oxygen; Oxygen content; Oxygen saturation; Oxygen tension; Phytochemicals; Plant extracts; Scientific imaging; Seeds; Sucrose; Terpenes; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Cannabis sativa L; anti-inflammatory effect; lipopolysaccharide; entourage effect

L. has been widely used by humans for centuries for various purposes, such as industrial, ceremonial, medicinal, and food. The bioactive components of L. can be classified into two main groups: cannabinoids and terpenes. These bioactive components of L. leaf and inflorescence extracts were analyzed....