Src‐dependent phosphorylation of μ‐opioid receptor at Tyr336 modulates opiate withdrawal

• Published in: EMBO molecular medicine Vol. 9; no. 11; pp. 1521 - 1536
• Main Authors: Zhang, Lei, Kibaly, Cherkaouia, Wang, Yu‐Jun, Xu, Chi, Song, Kyu Young, McGarrah, Patrick W, Loh, Horace H, Liu, Jing‐Gen, Law, Ping‐Yee
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.11.2017; John Wiley and Sons Inc; Springer Nature
• Subjects: EMBO27; lentivirus injection; locus coeruleus; naloxone‐precipitated opiate withdrawal; opiate addiction; Research Article; Src‐mediated phosphorylation of MOR at Tyr336; naloxone‐precipitated opiate withdrawal; lentivirus injection; opiate addiction; Src‐mediated phosphorylation of MOR at Tyr; locus coeruleus

Opiate withdrawal/negative reinforcement has been implicated as one of the mechanisms for the progression from impulsive to compulsive drug use. Increase in the intracellular cAMP level and protein kinase A (PKA) activities within the neurocircuitry of addiction has been a leading hypothesis for opi...