Quantification of Photoreceptors' Changes in a Diabetic Retinopathy Model with Two-Photon Imaging Microscopy

• Published in: International journal of molecular sciences Vol. 25; no. 16; p. 8756
• Main Authors: Bautista-Elivar, Nazario, Avilés-Trigueros, Marcelino, Bueno, Juan M
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 11.08.2024; MDPI
• Subjects: Animals; Diabetes; Diabetes Mellitus, Experimental - pathology; Diabetic retinopathy; Diabetic Retinopathy - diagnostic imaging; Diabetic Retinopathy - pathology; Disease; Disease Models, Animal; Homeostasis; Inflammation; Male; Microscopy; Microscopy - methods; Microscopy, Fluorescence, Multiphoton - methods; Neurodegeneration; neuroinflammation; Oxidative stress; Photoreceptor Cells, Vertebrate - pathology; photoreceptors; Rats; Retina; Retina - diagnostic imaging; Retina - pathology; two-photon microscopy; photoreceptors; two-photon microscopy; diabetic retinopathy; neuroinflammation

Emerging evidence suggests that retinal neurodegeneration is an early event in the pathogenesis of diabetic retinopathy (DR), preceding the development of microvascular abnormalities. Here, we assessed the impact of neuroinflammation on the retina of diabetic-induced rats. For this aim we have used...