Differential regulation of KCa2.1 (KCNN1) K+ channel expression by histone deacetylases in atrial fibrillation with concomitant heart failure

• Published in: Physiological reports Vol. 9; no. 11
• Main Authors: Rahm, Ann‐Kathrin, Wieder, Teresa, Gramlich, Dominik, Müller, Mara Elena, Wunsch, Maximilian N., El Tahry, Fadwa A., Heimberger, Tanja, Sandke, Steffi, Weis, Tanja, Most, Patrick, Katus, Hugo A., Thomas, Dierk, Lugenbiel, Patrick
• Format: Journal Article
• Language: English
• Published: Oxford John Wiley & Sons, Inc 01.06.2021; John Wiley and Sons Inc; Wiley
• Subjects: Action potential; atrial fibrillation; Calcium conductance; Cardiac arrhythmia; Cardiomyopathy; Cardiovascular disease; Congestive heart failure; Ejection fraction; electrophysiology; Epigenetics; Ethics; Experiments; Fibrillation; Gene expression; Heart failure; Histone deacetylase; KCa channel; Laboratory animals; Myocytes; Original; Patients; Phenotypes; Physiology; Potassium channels (calcium-gated); Potassium conductance; Proteins; siRNA; Transcription; Ventricle

Atrial fibrillation (AF) with concomitant heart failure (HF) poses a significant therapeutic challenge. Mechanism‐based approaches may optimize AF therapy. Small‐conductance, calcium‐activated K+ (KCa, KCNN) channels contribute to cardiac action potential repolarization. KCNN1 exhibits predominant a...