Evolutionary druggability for low-dimensional fitness landscapes toward new metrics for antimicrobial applications

• Published in: eLife Vol. 12
• Main Authors: Guerrero, Rafael F, Dorji, Tandin, Harris, Ra'Mal M, Shoulders, Matthew D, Ogbunugafor, C Brandon
• Format: Journal Article
• Language: English
• Published: England eLife Sciences Publications Ltd 04.06.2024; eLife Sciences Publications, Ltd
• Subjects: Alleles; Anti-Bacterial Agents - pharmacology; Antimicrobial agents; beta-Lactamases - genetics; beta-Lactamases - metabolism; beta-Lactams - pharmacology; Drug development; Drug interaction; Drug resistance; druggability; Evolution, Molecular; Evolutionary Biology; evolutionary genetics; Genetic diversity; Genetic Fitness; Genotype & phenotype; Mutation; Pathogens; Therapeutic targets; Topography; Viral infections; β Lactamase; β-Lactam antibiotics; druggability; evolutionary biology; drug resistance; E. coli; evolutionary genetics

The term 'druggability' describes the molecular properties of drugs or targets in pharmacological interventions and is commonly used in work involving drug development for clinical applications. There are no current analogues for this notion that quantify the drug-target interaction with r...