Relation of resistin levels with C-reactve protein, homocysteine and uric acid in smokers and non-smokers

• Published in: Journal of research in medical sciences Vol. 16; no. 10; pp. 1273 - 1279
• Main Authors: Esbah, Onur, Gürsoy, Gül, Kirnap, Nazli Gulsoy, Cetiner, Hacer, Demirbaş, Berrin, Acar, Yasar, Bayram, Murat
• Format: Journal Article
• Language: English
• Published: India Medknow Publications & Media Pvt. Ltd 01.10.2011; Medknow Publications & Media Pvt Ltd; Wolters Kluwer Medknow Publications
• Subjects: CRP; Homocysteine; Original; Resistin; Smoking; Uric Acid; CRP; Uric Acid; Homocysteine; Resistin; Smoking
• ISSN: 1735-1995; 1735-7136; 1735-1995

The association between C-reactive protein, homocysteine, uric acid levels and cardiovascular risk have been debated for decades. Resistin is a newly discovered adipocyte derived cytokine. Smoking besides its effect on atherosclerosis, is shown to alter adipocytokine levels. Bearing in mind, these complex relationship of resistin with smoking, C-reactive protein, homocysteine and uric acid, we planned to investigate the association of resistin and these cardiovascular risk factors in smoker and non-smoker subjects. We conducted a cross-sectional randomized study including 52 smoking and 33 non-smoking men. After making comparisons of C-reactive protein, homocysteine, uric acid and resistin between the two groups, we classified the subjects according to their insulin resistance and body mass and made again the comparisons.. Resistin levels were higher in smokers than in non-smokers (p<0.001) and also in insulin resistant than in non-insulin resistant smokers (p<0.05). Resistin levels were indifferent in non-smokers as insulin resistance was concerned and in smoker or non-smokers as body mass index was concerned. As all subjects were grouped based on homeostasis model assesment index and body mass index, neither C-reactive protein nor homocysteine and uric acid levels differred. We found that smoking may have influence on resistin levels and in smokers, insulin resistance is related to resistin levels, but in smoker and non-smokers body mass may not have any association with resistin. Resistin also may not have a role in C-reactive protein, homocysteine and uric acid levels both in smokers and non-smokers.