Guidelines for the Prevention and Treatment of Chronic Hepatitis B (Version 2022)

Abstract To facilitate the achieving of the goal of "eliminating viral hepatitis as a major public health threat by 2030" set by the World Health Organization, the Chinese Society of Hepatology together with the Chinese Society of Infectious Diseases (both are branches of the Chinese Medic...

Full description

Saved in:
Bibliographic Details
Published inMedicine (Baltimore) Vol. 3; no. 4; pp. 145 - 162
Main Authors You, Hong, Wang, Fu-Sheng, Li, Taisheng, Xu, Xiaoyuan, Sun, Yameng, Nan, Yuemin, Wang, Guiqiang, Hou, Jinlin, Duan, Zhongping, Wei, Lai, Jia, Jidong, Zhuang, Hui
Format Journal Article
LanguageEnglish
Published Lippincott Williams & Wilkins 01.10.2023
Wolters Kluwer
Subjects
Prevention
Guideline
Treatment
Hepatitis B, chronic
Online AccessGet full text

Cover

Abstract Abstract To facilitate the achieving of the goal of "eliminating viral hepatitis as a major public health threat by 2030" set by the World Health Organization, the Chinese Society of Hepatology together with the Chinese Society of Infectious Diseases (both are branches of the Chinese Medical Association) organized a panel of experts and updated the guidelines for prevention and treatment of chronic hepatitis B in China (version 2022). With the support of available evidence, this revision of the guidelines focuses on active prevention, large-scale testing, and expansion of therapeutic indication of chronic hepatitis B with the aim of reducing the hepatitis B-related disease burden.
AbstractList To facilitate the achieving of the goal of “eliminating viral hepatitis as a major public health threat by 2030” set by the World Health Organization, the Chinese Society of Hepatology together with the Chinese Society of Infectious Diseases (both are branches of the Chinese Medical Association) organized a panel of experts and updated the guidelines for prevention and treatment of chronic hepatitis B in China (version 2022). With the support of available evidence, this revision of the guidelines focuses on active prevention, large-scale testing, and expansion of therapeutic indication of chronic hepatitis B with the aim of reducing the hepatitis B–related disease burden.
Abstract To facilitate the achieving of the goal of "eliminating viral hepatitis as a major public health threat by 2030" set by the World Health Organization, the Chinese Society of Hepatology together with the Chinese Society of Infectious Diseases (both are branches of the Chinese Medical Association) organized a panel of experts and updated the guidelines for prevention and treatment of chronic hepatitis B in China (version 2022). With the support of available evidence, this revision of the guidelines focuses on active prevention, large-scale testing, and expansion of therapeutic indication of chronic hepatitis B with the aim of reducing the hepatitis B-related disease burden.
Author Wang, Guiqiang
Wang, Fu-Sheng
Wei, Lai
You, Hong
Duan, Zhongping
Zhuang, Hui
Li, Taisheng
Jia, Jidong
Hou, Jinlin
Sun, Yameng
Nan, Yuemin
Xu, Xiaoyuan
Author_xml – sequence: 1
  givenname: Hong
  surname: You
  fullname: You, Hong
  email: youhongliver@ccmu.edu.cn
– sequence: 2
  givenname: Fu-Sheng
  surname: Wang
  fullname: Wang, Fu-Sheng
  email: fswang302@163.com
– sequence: 3
  givenname: Taisheng
  surname: Li
  fullname: Li, Taisheng
  email: litsh@263.net
– sequence: 4
  givenname: Xiaoyuan
  surname: Xu
  fullname: Xu, Xiaoyuan
  email: youhongliver@ccmu.edu.cn
– sequence: 5
  givenname: Yameng
  surname: Sun
  fullname: Sun, Yameng
– sequence: 6
  givenname: Yuemin
  surname: Nan
  fullname: Nan, Yuemin
– sequence: 7
  givenname: Guiqiang
  surname: Wang
  fullname: Wang, Guiqiang
– sequence: 8
  givenname: Jinlin
  surname: Hou
  fullname: Hou, Jinlin
– sequence: 9
  givenname: Zhongping
  surname: Duan
  fullname: Duan, Zhongping
– sequence: 10
  givenname: Lai
  surname: Wei
  fullname: Wei, Lai
– sequence: 11
  givenname: Jidong
  surname: Jia
  fullname: Jia, Jidong
– sequence: 12
  givenname: Hui
  surname: Zhuang
  fullname: Zhuang, Hui
BookMark eNpdkMtOwzAQRS0EEqXwByy8hEWKH3FiL6FAWwkJkApbaxJPqEsaI8el4u8Jjw3MZqR7R0eac0T2u9AhIaecTTgz5cXi2kzYnzF6j4y4kkWmTJHvkxFjQmWlKfNDctT3a8a4LEU-Io-zrXfY-g572oRI0wrpQ8R37JIPHYXO0WVESJshoKGh01UMna_pHN8g-eR7ekXPnjH2X9eCCXF-TA4aaHs8-d1j8nR7s5zOs7v72WJ6eZc5yQqdlaIyeQVOG6kaxyoloHAN07wGpcuhgArqBrkupdaNUkYorAqueQlamkbIMVn8cF2AtX2LfgPxwwbw9jsI8cVCTL5u0QrklTDI61y7vHAcZCWEkYUUKEHVOLD0D2sX2jQ889pudxjtCqFNK8uZ_dJsB832v2b5CY0NcHE
Cites_doi doi:10.1111/jvh.13031
doi:10.1001/jamaoncol.2018.4070
doi:10.1002/hep.28278
doi:10.1016/S2468-1253(18)30056-6
doi:10.1016/j.jhep.2014.05.044
doi:10.1097/MEG.0000000000000388
doi:10.1007/s12072-021-10153-2
doi:10.1016/j.antiviral.2020.104783
doi:10.3760/cma.j.issn.1007-3418.2019.01.006
doi:10.1016/j.clinre.2020.10.008
doi:10.14218/JCTH.2021.00046
doi:10.1016/s0168-8278(03)00005-9
doi:10.1016/j.cgh.2021.04.045
doi:10.1016/0168-8278(95)80226-6
doi:10.3760/cma.j.issn.1007-3418.2018.03.009
doi:10.1002/jmv.27779
doi:10.1002/hep.28156
doi:10.14218/JCTH.2017.00072
doi:10.3389/fimmu.2020.610500
doi:10.1111/apt.14497
doi:10.3390/ijms221910462
doi:10.1111/jvh.13452
doi:10.3760/cma.j.issn.1007-3418.2019.11.008
doi:10.1056/NEJMoa051287
doi:10.1111/jvh.12613
doi:10.3760/cma.j.issn.1007-3418.2019.03.004
doi:10.1002/hep.29800
doi:10.1016/j.jhep.2020.09.034
doi:10.1016/j.jfma.2017.11.012
doi:10.1002/hep.29009
doi:10.1016/S0140-6736(12)61425-1
doi:10.1136/gutjnl-2014-308546
doi:10.1016/j.vaccine.2017.11.039
doi:10.1016/S2468-1253(19)30042-1
doi:10.1002/hep4.2064
doi:10.3389/fonc.2021.685706
doi:10.1016/j.cgh.2021.12.012
doi:10.2147/JHC.S271790
doi:10.1007/s12072-021-10262-y
doi:10.1136/gutjnl-2012-302056
doi:10.1016/j.jhep.2021.07.030
doi:10.1016/j.jhep.2012.04.029
doi:10.14309/ajg.0000000000000428
doi:10.1016/j.jhep.2020.07.025
doi:10.3969/j.issn.1001-5256.2021.06.007
doi:10.3760/cma.j.issn.1007-3418.2019.08.004
doi:10.1002/hep.21724
doi:10.1002/hep.31610
doi:10.21037/cco-20-107
doi:10.1053/j.gastro.2019.09.025
doi:10.1016/j.cgh.2019.07.010
doi:10.1136/gutjnl-2019-319867
doi:10.1002/hep.30050
doi:10.1016/j.jhep.2017.08.020
doi:10.1002/hep.31616
doi:10.1016/j.cgh.2020.12.005
doi:10.1111/apt.16125
doi:10.1016/j.clinre.2020.05.011
doi:10.1097/MCG.0000000000000822
doi:10.1016/j.jhep.2016.05.029
doi:10.1016/j.jhep.2022.01.007
doi:10.1111/jvh.12755
doi:10.1016/j.jhep.2022.07.018
doi:10.1080/23744235.2019.1675903
doi:10.1016/j.jhep.2017.11.039
doi:10.1016/j.jhep.2016.01.027
doi:10.1016/j.cgh.2022.01.047
doi:10.1002/hep.23348
doi:10.1111/liv.14786
doi:10.1016/j.vaccine.2017.10.032
doi:10.1007/s12072-021-10235-1
doi:10.1016/j.cmi.2017.06.023
doi:10.1007/s12072-014-9569-x
doi:10.7554/eLife.00049
doi:10.1111/apt.15311
doi:10.3760/cma.j.issn.1007-3418.2015.04.013
doi:10.3760/cma.j.issn.1007-3418.2019.07.009
doi:10.1111/hepr.12439
doi:10.1111/liv.13623
doi:10.1016/j.jhep.2019.02.021
doi:10.1007/s12072-019-09956-1
doi:10.1016/j.cgh.2019.07.046
doi:10.14309/ajg.0000000000001157
doi:10.1097/QAI.0000000000000927
doi:10.1111/jvh.13000
doi:10.1016/j.jhep.2021.09.017
doi:10.1016/j.jhep.2013.05.016
doi:10.1111/apt.16097
doi:10.1111/jvh.13058
doi:10.1111/apt.16611
doi:10.1016/j.jhep.2017.03.021
doi:10.1016/j.jhep.2014.02.015
doi:10.1007/s12072-020-10015-3
doi:10.1016/j.jhep.2017.07.011
doi:10.14218/JCTH.2017.00006
doi:10.1093/cid/cir755
doi:10.1016/j.cgh.2021.01.019
doi:10.1016/j.rcl.2019.01.004
doi:10.1080/22221751.2021.1899055
doi:10.1111/jvh.13511
doi:10.1002/hep4.1875
doi:10.1016/j.cgh.2016.03.024
doi:10.3760/cma.j.cn501113-20220209-00060
doi:10.1111/jvh.13463
doi:10.1002/hep.29082
doi:10.1016/j.vaccine.2017.11.037
doi:10.1007/s10620-010-1179-4
doi:10.3390/jpm11040267
doi:10.1136/gutjnl-2018-316641
doi:10.1007/s12072-021-10285-5
doi:10.1177/20406223221102791
doi:10.1097/MCG.0000000000000675
doi:10.3760/j.issn:1007-3418.1998.04.002
doi:10.1002/hep.22841
doi:10.1007/s12072-021-10239-x
doi:10.2147/IDR.S163038
doi:10.1136/gutjnl-2019-318278
doi:10.1002/hep.510240201
doi:10.1007/s12072-015-9675-4
doi:10.1038/s41598-017-03102-3
doi:10.3390/ijerph16162878
doi:10.1136/gutjnl-2020-321116
doi:10.1111/liv.13346
doi:10.1002/hep.32065
doi:10.1111/apt.17107
doi:10.3760/cma.j.issn.1007-3418.2019.12.007
doi:10.1002/hep.31026
doi:10.3969/j.issn.1001-5256.2013.02.009
doi:10.1111/liv.14223
doi:10.1111/j.1478-3231.2006.01287.x
doi:10.3760/cma.j.cn311365-20211030-00378
doi:10.1053/j.gastro.2021.11.002
doi:10.13419/j.cnki.aids.2017.06.30
doi:10.1111/apt.12726
doi:10.21037/atm.2016.11.52
doi:10.1016/j.cgh.2018.04.063
doi:10.3760/cma.j.cn115610-20220316-00135
doi:10.3201/eid2305.161477
doi:10.1016/j.jhep.2007.11.011
doi:10.3851/IMP3019
doi:10.3760/cma.j.issn.1007-3418.2019.08.003
doi:10.1002/hep4.1974
doi:10.1136/gutjnl-2020-323979
doi:10.5009/gnl210204
doi:10.1186/s12879-021-06237-x
doi:10.1016/j.jhep.2021.12.022
doi:10.1016/j.dld.2017.12.028
doi:10.3760/cma.j.cn115610-20220124-00053
doi:10.1002/hep.26385
doi:10.1136/gutjnl-2011-301073
doi:10.1016/j.jhep.2016.08.009
doi:10.1002/cncr.29537
doi:10.1111/jgh.15310
doi:10.1016/j.cgh.2020.03.001
doi:10.1136/bmj.f4503
doi:10.1002/hep.30637
doi:10.1007/s12072-019-10005-0
doi:10.1136/bmj.f3893
doi:10.1016/j.jhep.2020.11.023
doi:10.1016/j.jhep.2022.07.037
doi:10.1016/j.jhep.2005.10.013
doi:10.1016/j.cgh.2018.10.037
doi:10.1016/j.jhep.2022.01.021
doi:10.3760/cma.j.issn.1007-3418.2016.10.005
doi:10.1111/apt.13659
doi:10.1093/infdis/jiv572
doi:10.3760/cma.j.issn.1007-3418.2020.02.005
doi:10.1002/hep.24109
doi:10.1186/s12879-022-07854-w
doi:10.3748/wjg.v27.i36.6053
doi:10.1111/jvh.13722
doi:10.1111/eci.13575
doi:10.1136/gutjnl-2020-323153
doi:10.3969/j.issn.1001- 5256.2021.09.007
doi:10.14218/JCTH.2022.00091
doi:10.1016/j.cgh.2018.05.047
doi:10.1016/j.cgh.2021.07.036
doi:10.1053/j.gastro.2018.07.058
doi:10.1016/j.vaccine.2017.07.046
doi:10.1016/j.cmi.2014.10.002
doi:10.1111/liv.13046
doi:10.1016/j.jhep.2021.05.025
doi:10.14218/JCTH.2022.00058
doi:10.1111/jvh.13471
doi:10.3390/v14091887
doi:10.1002/hep.32352
doi:10.1016/0168-8278(91)90084-o
ContentType Journal Article
Copyright Copyright © 2023 The Chinese Medical Association, published by Wolters Kluwer Health, Inc.
Copyright_xml – notice: Copyright © 2023 The Chinese Medical Association, published by Wolters Kluwer Health, Inc.
DBID DOA
DOI 10.1097/ID9.0000000000000098
DatabaseName Directory of Open Access Journals
DatabaseTitleList

Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1536-5964
EndPage 162
ExternalDocumentID oai_doaj_org_article_2e1b29e1c48d46d1a3b2293632e3a5ce
IDI_230042
Genre research-article
GroupedDBID ---
.-D
.3C
.55
.GJ
.XZ
.Z2
01R
0R~
1CY
354
40H
4Q1
4Q2
4Q3
53G
5GY
5RE
5VS
71W
77Y
7O~
AAAAV
AAGIX
AAHPQ
AAIQE
AAMOA
AAQKA
AARTV
AASCR
AAWTL
AAXQO
AAYEP
ABASU
ABBUW
ABCQX
ABDIG
ABFRF
ABOCM
ABVCZ
ABXVJ
ABZAD
ABZZY
ACDDN
ACEWG
ACGFO
ACGFS
ACILI
ACLDA
ACWDW
ACWRI
ACXJB
ACXNZ
ACZKN
ADFPA
ADGGA
ADGHP
ADHPY
ADNKB
ADPDF
ADSXY
AE3
AE6
AEFWE
AENEX
AFBFQ
AFDTB
AFFNX
AFUWQ
AGOPY
AHOMT
AHQNM
AHRYX
AHVBC
AIJEX
AINUH
AJCLO
AJIOK
AJNWD
AJNYG
AJZMW
AKCTQ
AKULP
ALKUP
ALMA_UNASSIGNED_HOLDINGS
ALMTX
AMJPA
AMKUR
AMNEI
AOHHW
AOQMC
BQLVK
BS7
BYPQX
CS3
DIWNM
DU5
E.X
EBS
EEVPB
EJD
ERAAH
EX3
F2K
F2L
F2M
F2N
F5P
FCALG
FD6
FIJ
FL-
FW0
GNXGY
GQDEL
GROUPED_DOAJ
H0~
HLJTE
HYE
HZ~
H~9
IKREB
IKYAY
IN~
IPNFZ
JF9
JG8
JK3
JK8
K8S
KD2
KMI
KQ8
L-C
N4W
N9A
N~7
N~B
N~M
O9-
OAG
OAH
OB2
OCUKA
ODA
OHH
OK1
OL1
OLB
OLG
OLH
OLU
OLV
OLY
OLZ
OPUJH
ORVUJ
OUVQU
OVD
OVDNE
OVEED
OVIDH
OVLEI
OWU
OWV
OWW
OWZ
OXXIT
P-K
P2P
R58
RIG
RLZ
RPM
RXW
S4R
S4S
T8P
TAF
TEORI
TSPGW
UNMZH
V2I
VVN
W3M
WOQ
WOW
X3V
X3W
X7M
XXN
XYM
YFH
YOC
ZFV
ZGI
ZXP
ZY1
ID FETCH-LOGICAL-d3068-72b94bad8935fd0b52a6df081ca587badabacfe187388f55925eb61817a839f23
IEDL.DBID DOA
ISSN 0025-7974
IngestDate Wed Aug 27 01:31:31 EDT 2025
Wed Aug 20 00:37:32 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 4
Keywords Prevention
Guideline
Treatment
Hepatitis B, chronic
Language English
License http://creativecommons.org/licenses/by-nc-nd/4.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-d3068-72b94bad8935fd0b52a6df081ca587badabacfe187388f55925eb61817a839f23
Notes Corresponding authors: Hong You, E-mail: youhongliver@ccmu.edu.cn; Fu-Sheng Wang, E-mail: fswang302@163.com; Taisheng Li, E-mail: litsh@263.net; Xiaoyuan Xu, E-mail: xiaoyuanxu6@163.com Received: 13 July 2023 First online publication: September 15, 2023 This guideline manuscript was concurrently published in J Clin Transl Hepatol, 2023;11(6):1425-1442.. How to cite this article: You H, Wang FS, Li T, et al. Guidelines for the prevention and treatment of chronic hepatitis b (version 2022). Infect Dis Immun 2023;3(4):145-162. doi: 10.1097/ID9.0000000000000098
OpenAccessLink https://doaj.org/article/2e1b29e1c48d46d1a3b2293632e3a5ce
PageCount 18
ParticipantIDs doaj_primary_oai_doaj_org_article_2e1b29e1c48d46d1a3b2293632e3a5ce
wolterskluwer_health_10_1097_ID9_0000000000000098
PublicationCentury 2000
PublicationDate 20231000
PublicationDateYYYYMMDD 2023-10-01
PublicationDate_xml – month: 10
  year: 2023
  text: 20231000
PublicationDecade 2020
PublicationTitle Medicine (Baltimore)
PublicationTitleAbbrev Infect Dis Immun
PublicationYear 2023
Publisher Lippincott Williams & Wilkins
Wolters Kluwer
Publisher_xml – name: Lippincott Williams & Wilkins
– name: Wolters Kluwer
References Hui, Leung, Yuen (bib25) 2007; 46
Tseng, Hsu, Chang (bib68) 2018; 117
(bib13) 2018; 26
Cornberg, Wong, Locarnini (bib45) 2017; 66
Li, Lv, Wu (bib126) 2020; 14
(bib180) 2021; 39
Hall, Vogrin, Wawryk (bib135) 2021; 71
Wang, Liu, Zhou (bib88) 1998; 6
Yao, Liu, Wang (bib37) 2021; 28
Huang, Li, Le (bib36) 2022; 20
Wirth, Zhang, Hardikar (bib171) 2018; 68
Kong, Sun, Zhou (bib78) 2019; 26
Sonneveld, Park, Kaewdech (bib57) 2022; 20
Su, Berry, Ioannou (bib123) 2021; 70
Dong, Wu, Zhao (bib74) 2019; 26
Sun, Zhou, Wang (bib91) 2017; 65
Cui, Shen, Li (bib5) 2017; 23
Kim, Oh, Wanless (bib89) 2012; 57
Sun, Wu, Zhou (bib153) 2020; 18
Wang, Mubarik, Zhang (bib108) 2019; 16
Wai, Cheng, Wee (bib73) 2006; 26
Lu, Song, Zhai (bib164) 2021; 10
(bib76) 2019; 27
Chang, Aziz, Poongkunran (bib168) 2018; 52
(bib190) 2022; 21
Honda, Shirasaki, Terashima (bib58) 2016; 213
(bib4) 2021
Jonas, Lok, McMahon (bib174) 2016; 63
Sonneveld, Chiu, Park (bib59) 2022; 76
Kumar, Abbas, Azami (bib163) 2022; 16
Wu, Ma, Xie (bib98) 2021; 45
Stinco, Rubino, Trapani (bib24) 2021; 27
Cunha, Sirlin, Fowler (bib83) 2021; 10
Marcellin, Gane, Buti (bib116) 2013; 381
(bib75) 2021; 75
Yan, Zhong, Xu (bib18) 2012; 1
Westin, Aleman, Castedal (bib105) 2020; 52
McNaughton, D'Arienzo, Ansari (bib21) 2019; 156
Liu, Corsa, Buti (bib115) 2017; 24
Lee, Yang, Liu (bib99) 2013; 58
Zhu, Dong, Zhang (bib173) 2019; 27
Wu, Wang, Han (bib138) 2019; 13
McMahon, Nolen, Snowball (bib34) 2021; 74
Ogawa, Nakamuta, Koyanagi (bib130) 2022; 56
Nguyen, Atsukawa, Ishikawa (bib132) 2021; 116
Zhang, Peng, Liu (bib154) 2021; 9
(bib189) 2022; 30
Fan, Zhou, Xu (bib51) 2020; 18
Zhu, Dong, Xu (bib172) 2016; 24
Zhang, Li, Shang (bib54) 2020; 14
D'Amico, Garcia-Tsao, Pagliaro (bib92) 2006; 44
Fetzer, Rodgers, Seow (bib82) 2019; 57
Campbell, Wang, McNaughton (bib35) 2021; 28
Cai, Li, Yu (bib66) 2018; 11
(bib26) 2017; 67
Hou, Zhao, Lee (bib112) 2020; 18
Grossi, Loglio, Facchetti (bib178) 2018; 68
Li, Zhang, Lu (bib182) 2017; 23
Kao, Hu, Jia (bib102) 2020; 52
Liu, Jin, Zhang (bib134) 2023; 11
(bib6) 2018; 3
Indolfi, Easterbrook, Dusheiko (bib23) 2019; 4
Han, Jiang, Hou (bib140) 2016; 21
Duan, Chi, Xiao (bib97) 2021; 15
Wong, Seto, Wong (bib176) 2018; 47
Sarin, Kumar, Lau (bib104) 2016; 10
Tsai, Hsu, Hsiao (bib161) 2021; 11
Mak, Cloherty, Wong (bib52) 2021; 73
Sarmati, Andreoni, Antonelli (bib159) 2017; 23
Cao, Wang, Li (bib162) 2021; 11
World Health Organization. Prevention of Mother-to-Child Transmission of Hepatitis B Virus: Guidelines on Antiviral Prophylaxis in Pregnancy. Geneva: World Health Organization; 2020.
Tong, Revill (bib22) 2016; 64
Bertoletti, Ferrari (bib44) 2012; 61
Huang, Chen, Huang (bib124) 2022; 13
Chan, Chan, Hui (bib142) 2019; 26
Chen, Liu, Hu (bib192) 2015; 27
Dandri, Locarnini (bib39) 2012; 61
Wang, Zhao, Deng (bib94) 2022; 77
Choi, Yoo, Lim (bib30) 2021; 73
Scheuer (bib85) 1991; 13
Desmet (bib84) 2003; 38
Song, Lu, Li (bib15) 2022; 14
Wu, Kong, Piao (bib79) 2018; 38
(bib93) 2019; 27
Hsu, Mo, Chang (bib137) 2016; 14
Zhuang (bib38) 2021; 37
World Health Organization. Guidelines for the Prevention Care and Treatment of Persons with Chronic Hepatitis B Infection: Mar-15. Geneva: World Health Organization; 2015.
Ishak, Baptista, Bianchi (bib87) 1995; 22
Huang, Tam, Luo (bib185) 2017; 51
Zhou, Song, Zhao (bib61) 2017; 7
Li, Hu, Chen (bib187) 2021; 21
Liang, Chen (bib77) 2017; 5
Choi, Kim, Choi (bib107) 2019; 50
Peneau, Imbeaud, La Bella (bib19) 2022; 71
Miao, Yang, Dong (bib146) 2019; 27
Erken, Loukachov, van Dort (bib20) 2022; 76
Martin, Nguyen, Dieterich (bib103) 2022; 20
Su, Weiss, Beste (bib150) 2021; 74
Choi, Yip, Lim (bib127) 2022; 76
(bib1) 2019; 27
Schuch, Salimi Alizei, Heim (bib43) 2019; 68
Zeng, Zhang, Zhang (bib166) 2022; 20
Tayob, Kanwal, Alsarraj (bib71) 2023; 21
Seto, Liu, Mak (bib53) 2021; 70
Ning, Han, Sun (bib139) 2014; 61
Chen, Chu, Liaw (bib32) 2010; 51
Liu, Wu, Liu (bib72) 2020; 7
Liu, Jin, Zhang (bib133) 2021; 54
Huang, Wu, Wang (bib144) 2022; 77
Jang, Choi, Kim (bib155) 2018; 16
Paul, Dickstein, Saxena (bib157) 2017; 66
Lai, Shouval, Lok (bib113) 2006; 354
Komatsu, Inui, Fujisawa (bib170) 2017; 5
Rao, Duan, Wang (bib179) 2020; 28
(bib188) 2019; 27
Carey, Gersch, Wang (bib49) 2020; 72
(bib95) 2019; 27
Lau, Yu, Wong (bib156) 2021; 15
Terrault, Lok, McMahon (bib9) 2018; 67
Liu, Zhang, Li (bib147) 2023; 11
Yang, Li, Chen (bib148) 2015; 23
Yuen (bib183) 2015; 9
Wang, Shen, Huang (bib48) 2016; 65
Xu, Wang, Tai (bib90) 2014; 61
Lu, Feng, Zheng (bib152) 2021; 37
Ji, Chen, Bi (bib149) 2022; 77
Li, Liu, Liu (bib167) 2021; 15
Zhang, Zhang, Imamura (bib46) 2021; 75
Rajoriya, Combet, Zoulim (bib47) 2017; 67
Sarri, Westby, Bermingham (bib101) 2013; 346
Chon, Ahn, Kim (bib125) 2021; 15
Yonejima, Mizukoshi, Tamai (bib41) 2019; 70
Zhang, Liu, Li (bib60) 2022; 94
Garg, Sarin, Kumar (bib186) 2011; 53
Lampertico, Chan, Janssen (bib177) 2016; 44
Lee, Park, Lee (bib119) 2019; 17
Hsu, Wong, Chen (bib122) 2020; 115
Yip, Wong, Chan (bib121) 2020; 158
bib3
Terrault, Bzowej, Chang (bib100) 2016; 63
Liaw, Lau, Kao (bib27) 2010; 55
Li, Gong, Xie (bib69) 2021; 36
bib2
Lai, Mennini, Giovanardi (bib191) 2021; 51
Xiao, Sun, Duan (bib14) 2020; 69
Wu, Huang, Luo (bib160) 2020; 11
Lim, Gwak, Choi (bib118) 2019; 71
Li, Li, Xiong (bib145) 2017; 24
Li, Mao, Li (bib62) 2018; 50
Wang, Wen, Chang (bib81) 2021; 74
Xu, Liu, Wang (bib7) 2013; 347
Fan, Sun, Yuan (bib65) 2016; 65
Fattovich, Bortolotti, Donato (bib31) 2008; 48
Moro, Zheteyeva, Barash (bib17) 2018; 36
Hirode, Choi, Chen (bib136) 2022; 162
Dahari, Shlomai, Cotler (bib50) 2021; 28
De Franchis, Bosch, Garcia-Tsao (bib80) 2022; 76
Jiang, Li, Chen (bib184) 2013; 29
Song, Wang, Lu (bib29) 2021; 28
Li, Li, Niu (bib131) 2021; 41
Kayesh, Kohara, Tsukiyama-Kohara (bib40) 2021; 22
Chi, Li, Hansen (bib67) 2019; 17
Wei, Zhu, Liu (bib12) 2018; 36
Chuaypen, Posuwan, Payungporn (bib55) 2016; 36
Agarwal, Brunetto, Seto (bib128) 2018; 68
Song, Liu, Liu (bib63) 2015; 21
(bib11) 2019; 37
Wong, Seto, Cheung (bib56) 2017; 37
Choi, Kim, Lee (bib120) 2019; 5
Song, Zhang, Liu (bib16) 2022; 22
Sokal, Paganelli, Wirth (bib175) 2013; 59
Bedossa, Poynard (bib86) 1996; 24
Alshuwaykh, Daugherty, Cheung (bib109) 2022; 6
Zhang, Wu, Li (bib64) 2021; 45
Chu, Huang, Xie (bib143) 2022; 29
Li, Xie, Han (bib181) 2016; 72
Lu, Zhu, Liu (bib8) 2017; 35
Choi, Tonthat, Janssen (bib111) 2022; 6
Fan, Papatheodoridis, Sun (bib151) 2020; 73
Koffas, Petersen, Kennedy (bib106) 2020; 177
Isogawa, Tanaka (bib42) 2015; 45
Hu, Shang, Zhang (bib141) 2018; 6
Ahn, Choi, Ye (bib158) 2022; 16
Kim, Loomba, Berg (bib117) 2015; 121
Yeo, Nguyen (bib10) 2021; 53
Galle, Foerster, Kudo (bib70) 2019; 39
Chu, Liaw (bib28) 2012; 54
Duberg, Lybeck, Falt (bib33) 2022; 6
Nguyen, Tan, Greenup (bib169) 2014; 39
Tenney, Rose, Baldick (bib114) 2009; 49
Byun, Choi, Kim (bib129) 2022; 20
(bib96) 2022; 30
References_xml – volume: 26
  start-page: 297
  issue: 2
  year: 2019
  end-page: 307
  ident: bib74
  article-title: Evaluation and comparison of thirty noninvasive models for diagnosing liver fibrosis in Chinese hepatitis B patients
  publication-title: J Viral Hepat
  doi: doi:10.1111/jvh.13031
– volume: 5
  start-page: 30
  issue: 1
  year: 2019
  end-page: 36
  ident: bib120
  article-title: Risk of hepatocellular carcinoma in patients treated with entecavir vs tenofovir for chronic hepatitis B: a korean nationwide cohort study
  publication-title: JAMA Oncol
  doi: doi:10.1001/jamaoncol.2018.4070
– volume: 63
  start-page: 307
  issue: 1
  year: 2016
  end-page: 318
  ident: bib174
  article-title: Antiviral therapy in management of chronic hepatitis B viral infection in children: a systematic review and meta-analysis
  publication-title: Hepatology
  doi: doi:10.1002/hep.28278
– volume: 3
  start-page: 383
  issue: 6
  year: 2018
  end-page: 403
  ident: bib6
  article-title: Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling study
  publication-title: Lancet Gastroenterol Hepatol
  doi: doi:10.1016/S2468-1253(18)30056-6
– volume: 61
  start-page: 777
  issue: 4
  year: 2014
  end-page: 784
  ident: bib139
  article-title: Switching from entecavir to PegIFN alfa-2a in patients with HBeAg-positive chronic hepatitis B: a randomised open-label trial (OSST trial)
  publication-title: J Hepatol
  doi: doi:10.1016/j.jhep.2014.05.044
– volume: 27
  start-page: 901
  issue: 8
  year: 2015
  end-page: 906
  ident: bib192
  article-title: A new scheme with infusion of hepatitis B immunoglobulin combined with entecavir for prophylaxis of hepatitis B virus recurrence among liver transplant recipients
  publication-title: Eur J Gastroenterol Hepatol
  doi: doi:10.1097/MEG.0000000000000388
– volume: 15
  start-page: 318
  issue: 2
  year: 2021
  end-page: 327
  ident: bib97
  article-title: High-normal alanine aminotransferase is an indicator for liver histopathology in HBeAg-negative chronic hepatitis B
  publication-title: Hepatol Int
  doi: doi:10.1007/s12072-021-10153-2
– volume: 177
  start-page: 104783
  year: 2020
  ident: bib106
  article-title: Reasons to consider early treatment in chronic hepatitis B patients
  publication-title: Antiviral Res
  doi: doi:10.1016/j.antiviral.2020.104783
– volume: 27
  start-page: 18
  issue: 1
  year: 2019
  end-page: 26
  ident: bib188
  article-title: Guidelines for diagnosis and treatment of liver failure (2018 version)
  publication-title: J Clin Exp Hepatol
  doi: doi:10.3760/cma.j.issn.1007-3418.2019.01.006
– volume: 45
  start-page: 101563
  issue: 6
  year: 2021
  ident: bib64
  article-title: Combination of quantitative hepatitis B core antibody (qHBcAb) and aspartate aminotransferase (AST) can accurately diagnose immune tolerance of chronic hepatitis B virus infection based on liver biopsy
  publication-title: Clin Res Hepatol Gastroenterol
  doi: doi:10.1016/j.clinre.2020.10.008
– volume: 9
  start-page: 850
  issue: 6
  year: 2021
  end-page: 859
  ident: bib154
  article-title: Chronic hepatitis B infection with low level viremia correlates with the progression of the liver disease
  publication-title: J Clin Transl Hepatol
  doi: doi:10.14218/JCTH.2021.00046
– ident: bib3
  article-title: HBV progress towards coverage targets
– volume: 38
  start-page: 382
  issue: 4
  year: 2003
  end-page: 386
  ident: bib84
  article-title: Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis [Hepatology 1981;1:431-435]
  publication-title: J Hepatol
  doi: doi:10.1016/s0168-8278(03)00005-9
– volume: 20
  start-page: 427
  issue: 2
  year: 2022
  end-page: 437.e5
  ident: bib129
  article-title: Tenofovir alafenamide for drug-resistant hepatitis B: a randomized trial for switching from tenofovir disoproxil fumarate
  publication-title: Clin Gastroenterol Hepatol
  doi: doi:10.1016/j.cgh.2021.04.045
– volume: 22
  start-page: 696
  issue: 6
  year: 1995
  end-page: 699
  ident: bib87
  article-title: Histological grading and staging of chronic hepatitis
  publication-title: J Hepatol
  doi: doi:10.1016/0168-8278(95)80226-6
– volume: 26
  start-page: 204
  issue: 3
  year: 2018
  end-page: 208
  ident: bib13
  article-title: Consensus on clinical management of hepatitis B virus- infected women of childbearing age
  publication-title: Zhonghua Gan Zang Bing Za Zhi
  doi: doi:10.3760/cma.j.issn.1007-3418.2018.03.009
– volume: 94
  start-page: 3911
  issue: 8
  year: 2022
  end-page: 3923
  ident: bib60
  article-title: Dose-response relationship between qAnti-HBc and liver inflammation in chronic hepatitis B with normal or mildly elevated alanine transaminase based on liver biopsy
  publication-title: J Med Virol
  doi: doi:10.1002/jmv.27779
– volume: 63
  start-page: 261
  issue: 1
  year: 2016
  end-page: 283
  ident: bib100
  article-title: AASLD guidelines for treatment of chronic hepatitis B
  publication-title: Hepatology
  doi: doi:10.1002/hep.28156
– volume: 6
  start-page: 25
  issue: 1
  year: 2018
  end-page: 34
  ident: bib141
  article-title: HBsAg loss with peg-interferon alfa-2a in hepatitis B patients with partial response to nucleos(t)ide analog: new switch study
  publication-title: J Clin Transl Hepatol
  doi: doi:10.14218/JCTH.2017.00072
– volume: 11
  start-page: 610500
  year: 2020
  ident: bib160
  article-title: Management of hepatitis B virus in allogeneic hematopoietic stem cell transplantation
  publication-title: Front Immunol
  doi: doi:10.3389/fimmu.2020.610500
– volume: 47
  start-page: 730
  issue: 6
  year: 2018
  end-page: 737
  ident: bib176
  article-title: Review article: long-term safety of oral anti-viral treatment for chronic hepatitis B
  publication-title: Aliment Pharmacol Ther
  doi: doi:10.1111/apt.14497
– volume: 22
  start-page: 10462
  issue: 19
  year: 2021
  ident: bib40
  article-title: Toll-like receptor response to hepatitis B virus infection and potential of TLR agonists as immunomodulators for treating chronic hepatitis B: an overview
  publication-title: Int J Mol Sci
  doi: doi:10.3390/ijms221910462
– volume: 28
  start-page: 493
  issue: 3
  year: 2021
  end-page: 507
  ident: bib35
  article-title: Risk factors for the development of hepatocellular carcinoma (HCC) in chronic hepatitis B virus (HBV) infection: a systematic review and meta-analysis
  publication-title: J Viral Hepat
  doi: doi:10.1111/jvh.13452
– volume: 27
  start-page: 846
  issue: 11
  year: 2019
  end-page: 865
  ident: bib93
  article-title: Chinese guidelines on the management of liver cirrhosis
  publication-title: Zhonghua Gan Zang Bing Za Zhi
  doi: doi:10.3760/cma.j.issn.1007-3418.2019.11.008
– volume: 354
  start-page: 1011
  issue: 10
  year: 2006
  end-page: 1020
  ident: bib113
  article-title: Entecavir versus lamivudine for patients with HBeAg-negative chronic hepatitis B
  publication-title: N Engl J Med
  doi: doi:10.1056/NEJMoa051287
– volume: 24
  start-page: 68
  issue: 1
  year: 2017
  end-page: 74
  ident: bib115
  article-title: No detectable resistance to tenofovir disoproxil fumarate in HBeAg+ and HBeAg− patients with chronic hepatitis B after 8 years of treatment
  publication-title: J Viral Hepat
  doi: doi:10.1111/jvh.12613
– volume: 27
  start-page: 182
  issue: 3
  year: 2019
  end-page: 191
  ident: bib76
  article-title: Consensus on clinical application of transient elastography detecting liver fibrosis: a 2018 update
  publication-title: Zhonghua Gan Zang Bing Za Zhi
  doi: doi:10.3760/cma.j.issn.1007-3418.2019.03.004
– volume: 67
  start-page: 1560
  issue: 4
  year: 2018
  end-page: 1599
  ident: bib9
  article-title: Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance
  publication-title: Hepatology
  doi: doi:10.1002/hep.29800
– volume: 74
  start-page: 584
  issue: 3
  year: 2021
  end-page: 592
  ident: bib81
  article-title: Baveno VI criteria and spleen stiffness measurement rule out high-risk varices in virally suppressed HBV-related cirrhosis
  publication-title: J Hepatol
  doi: doi:10.1016/j.jhep.2020.09.034
– volume: 117
  start-page: 915
  issue: 10
  year: 2018
  end-page: 921
  ident: bib68
  article-title: Quantification of serum hepatitis B core antibody to predict off-entecavir relapse in patients with chronic hepatitis B
  publication-title: J Formos Med Assoc
  doi: doi:10.1016/j.jfma.2017.11.012
– volume: 65
  start-page: 1438
  issue: 5
  year: 2017
  end-page: 1450
  ident: bib91
  article-title: New classification of liver biopsy assessment for fibrosis in chronic hepatitis B patients before and after treatment
  publication-title: Hepatology
  doi: doi:10.1002/hep.29009
– volume: 381
  start-page: 468
  issue: 9865
  year: 2013
  end-page: 475
  ident: bib116
  article-title: Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study
  publication-title: Lancet
  doi: doi:10.1016/S0140-6736(12)61425-1
– volume: 65
  start-page: 313
  issue: 2
  year: 2016
  end-page: 320
  ident: bib65
  article-title: Baseline quantitative hepatitis B core antibody titre alone strongly predicts HBeAg seroconversion across chronic hepatitis B patients treated with peginterferon or nucleos(t)ide analogues
  publication-title: Gut
  doi: doi:10.1136/gutjnl-2014-308546
– volume: 36
  start-page: 50
  issue: 1
  year: 2018
  end-page: 54
  ident: bib17
  article-title: Assessing the safety of hepatitis B vaccination during pregnancy in the Vaccine Adverse Event Reporting System (VAERS), 1990-2016
  publication-title: Vaccine
  doi: doi:10.1016/j.vaccine.2017.11.039
– volume: 4
  start-page: 466
  issue: 6
  year: 2019
  end-page: 476
  ident: bib23
  article-title: Hepatitis B virus infection in children and adolescents
  publication-title: Lancet Gastroenterol Hepatol
  doi: doi:10.1016/S2468-1253(19)30042-1
– volume: 6
  start-page: 3052
  issue: 11
  year: 2022
  end-page: 3061
  ident: bib109
  article-title: Incidence of hepatocellular carcinoma in chronic hepatitis B virus infection in those not meeting criteria for antiviral therapy
  publication-title: Hepatol Commun
  doi: doi:10.1002/hep4.2064
– volume: 11
  start-page: 685706
  year: 2021
  ident: bib162
  article-title: HBV reactivation during the treatment of non-Hodgkin lymphoma and management strategies
  publication-title: Front Oncol
  doi: doi:10.3389/fonc.2021.685706
– volume: 20
  start-page: 2826
  issue: 12
  year: 2022
  end-page: 2837.e9
  ident: bib166
  article-title: Tenofovir alafenamide for pregnant Chinese women with active chronic hepatitis B: a multicenter prospective study
  publication-title: Clin Gastroenterol Hepatol
  doi: doi:10.1016/j.cgh.2021.12.012
– volume: 7
  start-page: 219
  year: 2020
  end-page: 232
  ident: bib72
  article-title: Validation of the GALAD model and establishment of GAAP model for diagnosis of hepatocellular carcinoma in Chinese patients
  publication-title: J Hepatocell Carcinoma
  doi: doi:10.2147/JHC.S271790
– volume: 15
  start-page: 1328
  issue: 6
  year: 2021
  end-page: 1336
  ident: bib125
  article-title: Efficacy of entecavir, tenofovir disoproxil fumarate, and tenofovir alafenamide in treatment-naive hepatitis B patients
  publication-title: Hepatol Int
  doi: doi:10.1007/s12072-021-10262-y
– volume: 61
  start-page: i6
  issue: Suppl 1
  year: 2012
  end-page: 17
  ident: bib39
  article-title: New insight in the pathobiology of hepatitis B virus infection
  publication-title: Gut
  doi: doi:10.1136/gutjnl-2012-302056
– ident: bib2
  article-title: Global hepatitis report, 2017
– volume: 75
  start-page: 1335
  issue: 6
  year: 2021
  end-page: 1345
  ident: bib46
  article-title: Infection courses, virological features and IFN-alpha responses of HBV genotypes in cell culture and animal models
  publication-title: J Hepatol
  doi: doi:10.1016/j.jhep.2021.07.030
– volume: 57
  start-page: 556
  issue: 3
  year: 2012
  end-page: 563
  ident: bib89
  article-title: The Laennec staging system for histological sub-classification of cirrhosis is useful for stratification of prognosis in patients with liver cirrhosis
  publication-title: J Hepatol
  doi: doi:10.1016/j.jhep.2012.04.029
– volume: 115
  start-page: 271
  issue: 2
  year: 2020
  end-page: 280
  ident: bib122
  article-title: Tenofovir versus entecavir for hepatocellular carcinoma prevention in an international consortium of chronic hepatitis B
  publication-title: Am J Gastroenterol
  doi: doi:10.14309/ajg.0000000000000428
– volume: 73
  start-page: 1368
  issue: 6
  year: 2020
  end-page: 1378
  ident: bib151
  article-title: aMAP risk score predicts hepatocellular carcinoma development in patients with chronic hepatitis
  publication-title: J Hepatol
  doi: doi:10.1016/j.jhep.2020.07.025
– volume: 37
  start-page: 1268
  issue: 6
  year: 2021
  end-page: 1274
  ident: bib152
  article-title: Current status of the research on low-level viremia in chronic hepatitis B patients receiving nucleos(t)ide analogues
  publication-title: J Clin Hepatol
  doi: doi:10.3969/j.issn.1001-5256.2021.06.007
– volume: 27
  start-page: 604
  issue: 8
  year: 2019
  end-page: 609
  ident: bib173
  article-title: A randomized controlled study on factors influencing the curative effect of sequential combined interferon and lamivudine therapy in children with immune-tolerant phase chronic hepatitis B
  publication-title: Zhonghua Gan Zang Bing Za Zhi
  doi: doi:10.3760/cma.j.issn.1007-3418.2019.08.004
– volume: 46
  start-page: 395
  issue: 2
  year: 2007
  end-page: 401
  ident: bib25
  article-title: Natural history and disease progression in Chinese chronic hepatitis B patients in immune-tolerant phase
  publication-title: Hepatology
  doi: doi:10.1002/hep.21724
– volume: 73
  start-page: 2155
  issue: 6
  year: 2021
  end-page: 2166
  ident: bib30
  article-title: Comparison of long-term clinical outcomes between spontaneous and therapy-induced HBsAg seroclearance
  publication-title: Hepatology
  doi: doi:10.1002/hep.31610
– volume: 10
  start-page: 3
  issue: 1
  year: 2021
  ident: bib83
  article-title: Imaging diagnosis of hepatocellular carcinoma: LI-RADS
  publication-title: Chin Clin Oncol
  doi: doi:10.21037/cco-20-107
– volume: 158
  start-page: 215
  issue: 1
  year: 2020
  end-page: 225.e6
  ident: bib121
  article-title: Tenofovir is associated with lower risk of hepatocellular carcinoma than entecavir in patients with chronic HBV infection in China
  publication-title: Gastroenterology
  doi: doi:10.1053/j.gastro.2019.09.025
– volume: 18
  start-page: 457
  issue: 2
  year: 2020
  end-page: 467.e21
  ident: bib112
  article-title: Outcomes of long-term treatment of chronic HBV infection with entecavir or other agents from a randomized trial in 24 countries
  publication-title: Clin Gastroenterol Hepatol
  doi: doi:10.1016/j.cgh.2019.07.010
– volume: 70
  start-page: 370
  issue: 2
  year: 2021
  end-page: 378
  ident: bib123
  article-title: No difference in hepatocellular carcinoma risk between chronic hepatitis B patients treated with entecavir versus tenofovir
  publication-title: Gut
  doi: doi:10.1136/gutjnl-2019-319867
– volume: 68
  start-page: 1681
  issue: 5
  year: 2018
  end-page: 1694
  ident: bib171
  article-title: Efficacy and safety of peginterferon alfa-2a (40KD) in children with chronic hepatitis B: the PEG-B-ACTIVE study
  publication-title: Hepatology
  doi: doi:10.1002/hep.30050
– volume: 68
  start-page: 195
  issue: 1
  year: 2018
  end-page: 198
  ident: bib178
  article-title: Tenofovir alafenamide as a rescue therapy in a patient with HBV-cirrhosis with a history of Fanconi syndrome and multidrug resistance
  publication-title: J Hepatol
  doi: doi:10.1016/j.jhep.2017.08.020
– volume: 73
  start-page: 2167
  issue: 6
  year: 2021
  end-page: 2179
  ident: bib52
  article-title: HBV RNA profiles in patients with chronic hepatitis B under different disease phases and antiviral therapy
  publication-title: Hepatology
  doi: doi:10.1002/hep.31616
– volume: 20
  start-page: e784
  issue: 4
  year: 2022
  end-page: 793
  ident: bib57
  article-title: Prediction of sustained response after nucleo(s)tide analogue cessation using HBsAg and HBcrAg levels: a multicenter study (CREATE)
  publication-title: Clin Gastroenterol Hepatol
  doi: doi:10.1016/j.cgh.2020.12.005
– volume: 53
  start-page: 63
  issue: 1
  year: 2021
  end-page: 78
  ident: bib10
  article-title: Review article: current gaps and opportunities in HBV prevention, testing and linkage to care in the United States-a call for action
  publication-title: Aliment Pharmacol Ther
  doi: doi:10.1111/apt.16125
– volume: 45
  issue: 2
  year: 2021
  end-page: 101463
  ident: bib98
  article-title: Significant histological changes and satisfying antiviral efficacy in chronic hepatitis B virus infection patients with normal alanine aminotransferase. Antiviral therapy decision in chronic HBV patients with normal ALT
  publication-title: Clin Res Hepatol Gastroenterol
  doi: doi:10.1016/j.clinre.2020.05.011
– volume: 52
  start-page: 255
  issue: 3
  year: 2018
  end-page: 261
  ident: bib168
  article-title: Serum aminotransferase flares in pregnant and postpartum women with current or prior treatment for chronic hepatitis B
  publication-title: J Clin Gastroenterol
  doi: doi:10.1097/MCG.0000000000000822
– volume: 65
  start-page: 700
  issue: 4
  year: 2016
  end-page: 710
  ident: bib48
  article-title: Serum hepatitis B virus RNA is encapsidated pregenome RNA that may be associated with persistence of viral infection and rebound
  publication-title: J Hepatol
  doi: doi:10.1016/j.jhep.2016.05.029
– volume: 76
  start-page: 1042
  issue: 5
  year: 2022
  end-page: 1050
  ident: bib59
  article-title: Probability of HBsAg loss after nucleo(s)tide analogue withdrawal depends on HBV genotype and viral antigen levels
  publication-title: J Hepatol
  doi: doi:10.1016/j.jhep.2022.01.007
– volume: 24
  start-page: 12
  issue: Suppl 1
  year: 2017
  end-page: 20
  ident: bib145
  article-title: Peginterferon is preferable to entecavir for prevention of unfavourable events in patients with HBeAg-positive chronic hepatitis B: a five-year observational cohort study
  publication-title: J Viral Hepat
  doi: doi:10.1111/jvh.12755
– volume: 77
  start-page: 1515
  issue: 6
  year: 2022
  end-page: 1524
  ident: bib149
  article-title: Entecavir plus Biejia-Ruangan compound reduces the risk of hepatocellular carcinoma in Chinese patients with chronic hepatitis B
  publication-title: J Hepatol
  doi: doi:10.1016/j.jhep.2022.07.018
– volume: 52
  start-page: 1
  issue: 1
  year: 2020
  end-page: 22
  ident: bib105
  article-title: Management of hepatitis B virus infection, updated Swedish guidelines
  publication-title: Infect Dis (Lond)
  doi: doi:10.1080/23744235.2019.1675903
– volume: 68
  start-page: 672
  issue: 4
  year: 2018
  end-page: 681
  ident: bib128
  article-title: 96 weeks treatment of tenofovir alafenamide vs. Tenofovir disoproxil fumarate for hepatitis B virus infection
  publication-title: J Hepatol
  doi: doi:10.1016/j.jhep.2017.11.039
– volume: 64
  start-page: S4
  issue: 1 Suppl
  year: 2016
  end-page: S16
  ident: bib22
  article-title: Overview of hepatitis B viral replication and genetic variability
  publication-title: J Hepatol
  doi: doi:10.1016/j.jhep.2016.01.027
– volume: 21
  start-page: 415
  issue: 2
  year: 2023
  end-page: 423.e4
  ident: bib71
  article-title: The performance of AFP, AFP-3, DCP as biomarkers for detection of hepatocellular carcinoma (HCC): a phase 3 biomarker study in the United States
  publication-title: Clin Gastroenterol Hepatol
  doi: doi:10.1016/j.cgh.2022.01.047
– volume: 51
  start-page: 435
  issue: 2
  year: 2010
  end-page: 444
  ident: bib32
  article-title: Age-specific prognosis following spontaneous hepatitis B e antigen seroconversion in chronic hepatitis B
  publication-title: Hepatology
  doi: doi:10.1002/hep.23348
– volume: 41
  start-page: 1254
  issue: 6
  year: 2021
  end-page: 1264
  ident: bib131
  article-title: Switching from entecavir to tenofovir alafenamide for chronic hepatitis B patients with low level viraemia
  publication-title: Liver Int
  doi: doi:10.1111/liv.14786
– volume: 35
  start-page: 6627
  issue: 48
  year: 2017
  end-page: 6633
  ident: bib8
  article-title: The maternal viral threshold for antiviral prophylaxis of perinatal hepatitis B virus transmission in settings with limited resources: a large prospective cohort study in China
  publication-title: Vaccine
  doi: doi:10.1016/j.vaccine.2017.10.032
– volume: 15
  start-page: 1103
  issue: 5
  year: 2021
  end-page: 1108
  ident: bib167
  article-title: Efficacy and safety of tenofovir disoproxil fumarate and tenofovir alafenamide fumarate in preventing HBV vertical transmission of high maternal viral load
  publication-title: Hepatol Int
  doi: doi:10.1007/s12072-021-10235-1
– volume: 23
  start-page: 935
  issue: 12
  year: 2017
  end-page: 940
  ident: bib159
  article-title: Recommendations for screening, monitoring, prevention, prophylaxis and therapy of hepatitis B virus reactivation in patients with haematologic malignancies and patients who underwent haematologic stem cell transplantation-a position paper
  publication-title: Clin Microbiol Infect
  doi: doi:10.1016/j.cmi.2017.06.023
– volume: 9
  start-page: 373
  issue: 3
  year: 2015
  end-page: 377
  ident: bib183
  article-title: Anti-viral therapy in hepatitis B virus reactivation with acute-on-chronic liver failure
  publication-title: Hepatol Int
  doi: doi:10.1007/s12072-014-9569-x
– volume: 1
  start-page: e00049
  year: 2012
  ident: bib18
  article-title: Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus
  publication-title: Elife
  doi: doi:10.7554/eLife.00049
– volume: 50
  start-page: 215
  issue: 2
  year: 2019
  end-page: 226
  ident: bib107
  article-title: High risk of clinical events in untreated HBeAg-negative chronic hepatitis B patients with high viral load and no significant ALT elevation
  publication-title: Aliment Pharmacol Ther
  doi: doi:10.1111/apt.15311
– volume: 23
  start-page: 295
  issue: 4
  year: 2015
  end-page: 296
  ident: bib148
  article-title: Meta-analysis of the efficacy of Fuzhenghuayu capsule on hepatic fibrosis of CHB
  publication-title: Zhonghua Gan Zang Bing Za Zhi
  doi: doi:10.3760/cma.j.issn.1007-3418.2015.04.013
– volume: 27
  start-page: 521
  issue: 7
  year: 2019
  end-page: 526
  ident: bib146
  article-title: Combined anluohuaxianwan and entecavir treatment significantly improve the improvement rate of liver fibrosis in patients with chronic hepatitis B virus infection
  publication-title: Zhonghua Gan Zang Bing Za Zhi
  doi: doi:10.3760/cma.j.issn.1007-3418.2019.07.009
– volume: 45
  start-page: 179
  issue: 2
  year: 2015
  end-page: 189
  ident: bib42
  article-title: Immunobiology of hepatitis B virus infection
  publication-title: Hepatol Res
  doi: doi:10.1111/hepr.12439
– volume: 38
  start-page: 1045
  issue: 6
  year: 2018
  end-page: 1054
  ident: bib79
  article-title: On-treatment changes of liver stiffness at week 26 could predict 2-year clinical outcomes in HBV-related compensated cirrhosis
  publication-title: Liver Int
  doi: doi:10.1111/liv.13623
– volume: 71
  start-page: 35
  issue: 1
  year: 2019
  end-page: 44
  ident: bib118
  article-title: Monotherapy with tenofovir disoproxil fumarate for adefovir-resistant vs. Entecavir-resistant chronic hepatitis B: a 5-year clinical trial
  publication-title: J Hepatol
  doi: doi:10.1016/j.jhep.2019.02.021
– volume: 13
  start-page: 573
  issue: 5
  year: 2019
  end-page: 586
  ident: bib138
  article-title: Sequential combination therapy with interferon, interleukin-2 and therapeutic vaccine in entecavir-suppressed chronic hepatitis B patients: the endeavor study
  publication-title: Hepatol Int
  doi: doi:10.1007/s12072-019-09956-1
– volume: 18
  start-page: 719
  issue: 3
  year: 2020
  end-page: 727.e7
  ident: bib51
  article-title: Association between negative results from tests for HBV DNA and RNA and durability of response after discontinuation of nucles(t)ide analogue therapy
  publication-title: Clin Gastroenterol Hepatol
  doi: doi:10.1016/j.cgh.2019.07.046
– volume: 116
  start-page: 1264
  issue: 6
  year: 2021
  end-page: 1273
  ident: bib132
  article-title: Outcomes of sequential therapy with tenofovir alafenamide after long-term entecavir
  publication-title: Am J Gastroenterol
  doi: doi:10.14309/ajg.0000000000001157
– volume: 72
  start-page: 39
  issue: 1
  year: 2016
  end-page: 45
  ident: bib181
  article-title: Lamivudine monotherapy-based cART is efficacious for HBV treatment in HIV/HBV coinfection when baseline HBV DNA <20,000 IU/mL
  publication-title: J Acquir Immune Defic Syndr
  doi: doi:10.1097/QAI.0000000000000927
– volume: 26
  start-page: 126
  issue: 1
  year: 2019
  end-page: 135
  ident: bib142
  article-title: Switching to peginterferon for chronic hepatitis B patients with hepatitis B e antigen seroconversion on entecavir-a prospective study
  publication-title: J Viral Hepat
  doi: doi:10.1111/jvh.13000
– volume: 76
  start-page: 186
  issue: 1
  year: 2022
  end-page: 194
  ident: bib127
  article-title: Methodological challenges of performing meta-analyses to compare the risk of hepatocellular carcinoma between chronic hepatitis B treatments
  publication-title: J Hepatol
  doi: doi:10.1016/j.jhep.2021.09.017
– volume: 59
  start-page: 814
  issue: 4
  year: 2013
  end-page: 829
  ident: bib175
  article-title: Management of chronic hepatitis B in childhood: ESPGHAN clinical practice guidelines: consensus of an expert panel on behalf of the European Society of Pediatric Gastroenterology, Hepatology and Nutrition
  publication-title: J Hepatol
  doi: doi:10.1016/j.jhep.2013.05.016
– volume: 52
  start-page: 1540
  issue: 10
  year: 2020
  end-page: 1550
  ident: bib102
  article-title: East Asia expert opinion on treatment initiation for chronic hepatitis B
  publication-title: Aliment Pharmacol Ther
  doi: doi:10.1111/apt.16097
– volume: 26
  start-page: 576
  issue: 5
  year: 2019
  end-page: 585
  ident: bib78
  article-title: Early steep decline of liver stiffness predicts histological reversal of fibrosis in chronic hepatitis B patients treated with entecavir
  publication-title: J Viral Hepat
  doi: doi:10.1111/jvh.13058
– volume: 54
  start-page: 1134
  issue: 9
  year: 2021
  end-page: 1149
  ident: bib133
  article-title: Randomised clinical trial: 48 weeks of treatment with tenofovir amibufenamide versus tenofovir disoproxil fumarate for patients with chronic hepatitis B
  publication-title: Aliment Pharmacol Ther
  doi: doi:10.1111/apt.16611
– volume: 67
  start-page: 370
  issue: 2
  year: 2017
  end-page: 398
  ident: bib26
  article-title: EASL 2017 clinical practice guidelines on the management of hepatitis B virus infection
  publication-title: J Hepatol
  doi: doi:10.1016/j.jhep.2017.03.021
– volume: 61
  start-page: 260
  issue: 2
  year: 2014
  end-page: 269
  ident: bib90
  article-title: qFibrosis: a fullyquantitative innovative method incorporating histological features to facilitate accurate fibrosis scoring in animal model and chronic hepatitis B patients
  publication-title: J Hepatol
  doi: doi:10.1016/j.jhep.2014.02.015
– volume: 14
  start-page: 212
  issue: 2
  year: 2020
  end-page: 224
  ident: bib54
  article-title: Rapidly decreased HBV RNA predicts responses of pegylated interferons in HBeAg-positive patients: a longitudinal cohort study
  publication-title: Hepatol Int
  doi: doi:10.1007/s12072-020-10015-3
– volume: 67
  start-page: 1281
  issue: 6
  year: 2017
  end-page: 1297
  ident: bib47
  article-title: How viral genetic variants and genotypes influence disease and treatment outcome of chronic hepatitis B. Time for an individualised approach?
  publication-title: J Hepatol
  doi: doi:10.1016/j.jhep.2017.07.011
– volume: 5
  start-page: 368
  issue: 4
  year: 2017
  end-page: 375
  ident: bib77
  article-title: Clinical application of vibration controlled transient elastography in patients with chronic hepatitis B
  publication-title: J Clin Transl Hepatol
  doi: doi:10.14218/JCTH.2017.00006
– volume: 54
  start-page: 88
  issue: 1
  year: 2012
  end-page: 90
  ident: bib28
  article-title: Prevalence of and risk factors for hepatitis B viremia after spontaneous hepatitis B surface antigen seroclearance in hepatitis B carriers
  publication-title: Clin Infect Dis
  doi: doi:10.1093/cid/cir755
– volume: 20
  start-page: 1803
  issue: 8
  year: 2022
  end-page: 1812.e5
  ident: bib36
  article-title: Natural history and hepatocellular carcinoma risk in untreated chronic hepatitis B patients with indeterminate phase
  publication-title: Clin Gastroenterol Hepatol
  doi: doi:10.1016/j.cgh.2021.01.019
– volume: 57
  start-page: 563
  issue: 3
  year: 2019
  end-page: 583
  ident: bib82
  article-title: Ultrasound evaluation in patients at risk for hepatocellular carcinoma
  publication-title: Radiol Clin North Am
  doi: doi:10.1016/j.rcl.2019.01.004
– volume: 10
  start-page: 555
  issue: 1
  year: 2021
  end-page: 564
  ident: bib164
  article-title: Maternal hepatitis B eantigen can be an indicator for antiviral prophylaxis of perinatal transmission of hepatitis B virus
  publication-title: Emerg Microbes Infect
  doi: doi:10.1080/22221751.2021.1899055
– volume: 28
  start-page: 1025
  issue: 7
  year: 2021
  end-page: 1033
  ident: bib37
  article-title: Distribution and clinical characteristics of patients with chronic hepatitis B virus infection in the grey zone
  publication-title: J Viral Hepat
  doi: doi:10.1111/jvh.13511
– volume: 6
  start-page: 935
  issue: 5
  year: 2022
  end-page: 949
  ident: bib111
  article-title: Aiming for functional cure with established and novel therapies for chronic hepatitis B
  publication-title: Hepatol Commun
  doi: doi:10.1002/hep4.1875
– volume: 14
  start-page: 1490
  issue: 10
  year: 2016
  end-page: 1498.e3
  ident: bib137
  article-title: Association between serum level of hepatitis B surface antigen at end of entecavir therapy and risk of relapse in E antigen-negative patients
  publication-title: Clin Gastroenterol Hepatol
  doi: doi:10.1016/j.cgh.2016.03.024
– volume: 30
  start-page: 131
  issue: 2
  year: 2022
  end-page: 136
  ident: bib96
  article-title: Expert opinion on expanding anti-HBV treatment for chronic hepatitis B
  publication-title: Zhonghua Gan Zang Bing Za Zhi
  doi: doi:10.3760/cma.j.cn501113-20220209-00060
– reference: World Health Organization. Guidelines for the Prevention Care and Treatment of Persons with Chronic Hepatitis B Infection: Mar-15. Geneva: World Health Organization; 2015.
– volume: 28
  start-page: 687
  issue: 4
  year: 2021
  end-page: 688
  ident: bib50
  article-title: Early HBV RNA kinetics under NA treatment may reveal new insights into HBV RNA dynamics and NA mode of action-more detailed kinetic studies are needed
  publication-title: J Viral Hepat
  doi: doi:10.1111/jvh.13463
– volume: 66
  start-page: 379
  issue: 2
  year: 2017
  end-page: 388
  ident: bib157
  article-title: Role of surface antibody in hepatitis B reactivation in patients with resolved infection and hematologic malignancy: a meta-analysis
  publication-title: Hepatology
  doi: doi:10.1002/hep.29082
– volume: 36
  start-page: 256
  issue: 2
  year: 2018
  end-page: 263
  ident: bib12
  article-title: The efficacy of two different dosages of hepatitis B immunoglobulin combined with hepatitis B vaccine in preventing mother-to-child transmission of hepatitis B virus: a prospective cohort study
  publication-title: Vaccine
  doi: doi:10.1016/j.vaccine.2017.11.037
– volume: 55
  start-page: 2727
  issue: 10
  year: 2010
  end-page: 2734
  ident: bib27
  article-title: Hepatitis B e antigen seroconversion: a critical event in chronic hepatitis B virus infection
  publication-title: Dig Dis Sci
  doi: doi:10.1007/s10620-010-1179-4
– volume: 11
  start-page: 267
  issue: 4
  year: 2021
  ident: bib161
  article-title: Management of hepatitis B virus reactivation in malignant lymphoma prior to immunosuppressive treatment
  publication-title: J Pers Med
  doi: doi:10.3390/jpm11040267
– volume: 68
  start-page: 905
  issue: 5
  year: 2019
  end-page: 915
  ident: bib43
  article-title: Phenotypic and functional differences of HBV core-specific versus HBV polymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load
  publication-title: Gut
  doi: doi:10.1136/gutjnl-2018-316641
– volume: 16
  start-page: 211
  issue: 2
  year: 2022
  end-page: 253
  ident: bib163
  article-title: Asian pacific association for the study of liver (APASL) guidelines: hepatitis B virus in pregnancy
  publication-title: Hepatol Int
  doi: doi:10.1007/s12072-021-10285-5
– volume: 13
  start-page: 20406223221102791
  year: 2022
  ident: bib124
  article-title: Tenofovir is superior to entecavir in reducing HCC for patients with HBV-related compensated cirrhosis at high HCC risk scores
  publication-title: Ther Adv Chronic Dis
  doi: doi:10.1177/20406223221102791
– reference: World Health Organization. Prevention of Mother-to-Child Transmission of Hepatitis B Virus: Guidelines on Antiviral Prophylaxis in Pregnancy. Geneva: World Health Organization; 2020.
– volume: 51
  start-page: 539
  issue: 6
  year: 2017
  end-page: 547
  ident: bib185
  article-title: Efficacy and safety of lamivudine versus entecavir for treating chronic hepatitis B virus-related acute exacerbation and acute-on-chronic liver failure: a systematic review and meta-analysis
  publication-title: J Clin Gastroenterol
  doi: doi:10.1097/MCG.0000000000000675
– volume: 6
  start-page: 195
  issue: 4
  year: 1998
  end-page: 197
  ident: bib88
  article-title: Scoring system for inflammatory activity and fibrosis degree in chronic hepatitis
  publication-title: Zhonghua Xue Ye Xue Za Zhi
  doi: doi:10.3760/j.issn:1007-3418.1998.04.002
– volume: 49
  start-page: 1503
  issue: 5
  year: 2009
  end-page: 1514
  ident: bib114
  article-title: Long-term monitoring shows hepatitis B virus resistance to entecavir in nucleoside-naive patients is rare through 5 years of therapy
  publication-title: Hepatology
  doi: doi:10.1002/hep.22841
– volume: 15
  start-page: 1031
  issue: 5
  year: 2021
  end-page: 1048
  ident: bib156
  article-title: APASL clinical practice guideline on hepatitis B reactivation related to the use of immunosuppressive therapy
  publication-title: Hepatol Int
  doi: doi:10.1007/s12072-021-10239-x
– volume: 11
  start-page: 469
  year: 2018
  end-page: 477
  ident: bib66
  article-title: Serum hepatitis B core antibody levels predict HBeAg seroconversion in chronic hepatitis B patients with high viral load treated with nucleos(t)ide analogs
  publication-title: Infect Drug Resist
  doi: doi:10.2147/IDR.S163038
– volume: 69
  start-page: 933
  issue: 5
  year: 2020
  end-page: 941
  ident: bib14
  article-title: Quasispecies characteristic in "a" determinant region is a potential predictor for the risk of immunoprophylaxis failure of mother-to-child-transmission of sub-genotype C2 hepatitis B virus: a prospective nested case-control study
  publication-title: Gut
  doi: doi:10.1136/gutjnl-2019-318278
– volume: 24
  start-page: 289
  issue: 2
  year: 1996
  end-page: 293
  ident: bib86
  article-title: An algorithm for the grading of activity in chronic hepatitis C. The METAVIR cooperative study group
  publication-title: Hepatology
  doi: doi:10.1002/hep.510240201
– volume: 10
  start-page: 1
  issue: 1
  year: 2016
  end-page: 98
  ident: bib104
  article-title: Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update
  publication-title: Hepatol Int
  doi: doi:10.1007/s12072-015-9675-4
– volume: 7
  start-page: 2747
  issue: 1
  year: 2017
  ident: bib61
  article-title: Serum hepatitis B core antibody as a biomarker of hepatic inflammation in chronic hepatitis B patients with normal alanine aminotransferase
  publication-title: Sci Rep
  doi: doi:10.1038/s41598-017-03102-3
– volume: 16
  start-page: 2878
  issue: 16
  year: 2019
  ident: bib108
  article-title: Long-term trends of liver cancer incidence and mortality in China 1990-2017: a joinpoint and age-period-cohort analysis
  publication-title: Int J Environ Res Public Health
  doi: doi:10.3390/ijerph16162878
– volume: 70
  start-page: 775
  issue: 4
  year: 2021
  end-page: 783
  ident: bib53
  article-title: Role of serum HBV RNA and hepatitis B surface antigen levels in identifying Asian patients with chronic hepatitis B suitable for entecavir cessation
  publication-title: Gut
  doi: doi:10.1136/gutjnl-2020-321116
– volume: 37
  start-page: 995
  issue: 7
  year: 2017
  end-page: 1001
  ident: bib56
  article-title: Hepatitis B virus core-related antigen as a surrogate marker for covalently closed circular DNA
  publication-title: Liver Int
  doi: doi:10.1111/liv.13346
– volume: 74
  start-page: 2965
  issue: 6
  year: 2021
  end-page: 2973
  ident: bib34
  article-title: HBV genotype: a significant risk factor in determining which patients with chronic HBV infection should undergo surveillance for HCC: the hepatitis B Alaska study
  publication-title: Hepatology
  doi: doi:10.1002/hep.32065
– volume: 56
  start-page: 713
  issue: 4
  year: 2022
  end-page: 722
  ident: bib130
  article-title: Switching to tenofovir alafenamide for nucleos(t)ide analogue-experienced patients with chronic hepatitis B: week 144 results from a real-world, multi-centre cohort study
  publication-title: Aliment Pharmacol Ther
  doi: doi:10.1111/apt.17107
– volume: 27
  start-page: 938
  issue: 12
  year: 2019
  end-page: 961
  ident: bib1
  article-title: The guidelines of prevention and treatment for chronic hepatitis B (2019 version)
  publication-title: Zhonghua Gan Zang Bing Za Zhi
  doi: doi:10.3760/cma.j.issn.1007-3418.2019.12.007
– volume: 72
  start-page: 42
  issue: 1
  year: 2020
  end-page: 57
  ident: bib49
  article-title: Pregenomic HBV RNA and hepatitis B core-related antigen predict outcomes in hepatitis B e antigen-negative chronic hepatitis B patients suppressed on nucleos(t)ide analogue therapy
  publication-title: Hepatology
  doi: doi:10.1002/hep.31026
– volume: 29
  start-page: 110
  issue: 2
  year: 2013
  end-page: 113
  ident: bib184
  article-title: Short-term and long-term efficacy of antiviral treatment of patients with HBV-associated acute-on-chronic liver failure
  publication-title: J Clin Hepatol
  doi: doi:10.3969/j.issn.1001-5256.2013.02.009
– year: 2021
  ident: bib4
  article-title: Accountability for the global health sector strategies 2016-2021: actions for impact. Global progress report on HIV, viral hepatitis and sexually transmitted infections
– volume: 39
  start-page: 2214
  issue: 12
  year: 2019
  end-page: 2229
  ident: bib70
  article-title: Biology and significance of alpha-fetoprotein in hepatocellular carcinoma
  publication-title: Liver Int
  doi: doi:10.1111/liv.14223
– volume: 26
  start-page: 666
  issue: 6
  year: 2006
  end-page: 672
  ident: bib73
  article-title: Non-invasive models for predicting histology in patients with chronic hepatitis B
  publication-title: Liver Int
  doi: doi:10.1111/j.1478-3231.2006.01287.x
– volume: 39
  start-page: 715
  issue: 12
  year: 2021
  end-page: 735
  ident: bib180
  article-title: Chinese guidelines for HIV/AIDS diagnosis and treatment (2021 version)
  publication-title: Chinese J Infect Dis
  doi: doi:10.3760/cma.j.cn311365-20211030-00378
– volume: 162
  start-page: 757
  issue: 3
  year: 2022
  end-page: 771.e4
  ident: bib136
  article-title: Off-therapy response after nucleos(t)ide analogue withdrawal in patients with chronic hepatitis B: an international, multicenter, multiethnic cohort (RETRACT-B study)
  publication-title: Gastroenterology
  doi: doi:10.1053/j.gastro.2021.11.002
– volume: 23
  start-page: 578
  issue: 6
  year: 2017
  end-page: 581
  ident: bib182
  article-title: Expert consensus on the management of patients with HIV infection and chronic kidney disease
  publication-title: Chinese J AIDS STD
  doi: doi:10.13419/j.cnki.aids.2017.06.30
– volume: 39
  start-page: 1225
  issue: 10
  year: 2014
  end-page: 1234
  ident: bib169
  article-title: Anti-viral therapy for prevention of perinatal HBV transmission: extending therapy beyond birth does not protect against post-partum flare
  publication-title: Aliment Pharmacol Ther
  doi: doi:10.1111/apt.12726
– volume: 5
  start-page: 37
  issue: 3
  year: 2017
  ident: bib170
  article-title: Pediatric hepatitis B treatment
  publication-title: Ann Transl Med
  doi: doi:10.21037/atm.2016.11.52
– volume: 16
  start-page: 1954
  issue: 12
  year: 2018
  end-page: 1963.e3
  ident: bib155
  article-title: Effects of virologic response to treatment on short- and long-term outcomes of patients with chronic hepatitis B virus infection and decompensated cirrhosis
  publication-title: Clin Gastroenterol Hepatol
  doi: doi:10.1016/j.cgh.2018.04.063
– volume: 21
  start-page: 433
  issue: 4
  year: 2022
  end-page: 443
  ident: bib190
  article-title: Chinese clinical practice guidelines on liver transplantation for hepatocellular carcinoma (2021 edition)
  publication-title: Chinese J Digest Surg
  doi: doi:10.3760/cma.j.cn115610-20220316-00135
– volume: 23
  start-page: 765
  issue: 5
  year: 2017
  end-page: 772
  ident: bib5
  article-title: Prevention of chronic hepatitis B after 3 decades of escalating vaccination policy, China
  publication-title: Emerg Infect Dis
  doi: doi:10.3201/eid2305.161477
– volume: 48
  start-page: 335
  issue: 2
  year: 2008
  end-page: 352
  ident: bib31
  article-title: Natural history of chronic hepatitis B: special emphasis on disease progression and prognostic factors
  publication-title: J Hepatol
  doi: doi:10.1016/j.jhep.2007.11.011
– volume: 21
  start-page: 337
  issue: 4
  year: 2016
  end-page: 344
  ident: bib140
  article-title: Sustained immune control in HBeAg-positive patients who switched from entecavir therapy to pegylated interferon-α2a: 1 year follow-up of the OSST study
  publication-title: Antivir Ther
  doi: doi:10.3851/IMP3019
– volume: 27
  start-page: 594
  issue: 8
  year: 2019
  end-page: 603
  ident: bib95
  article-title: The expert consensus on clinical cure (functional cure) of chronic hepatitis B
  publication-title: Zhonghua Gan Zang Bing Za Zhi
  doi: doi:10.3760/cma.j.issn.1007-3418.2019.08.003
– volume: 6
  start-page: 2418
  issue: 9
  year: 2022
  end-page: 2430
  ident: bib33
  article-title: Chronic hepatitis B virus infection and the risk of hepatocellular carcinoma by age and country of origin in people living in Sweden: a national register study
  publication-title: Hepatol Commun
  doi: doi:10.1002/hep4.1974
– volume: 71
  start-page: gutjnl-2020-323979
  issue: 8
  year: 2021
  end-page: 1641
  ident: bib135
  article-title: Discontinuation of nucleot(s)ide analogue therapy in HBeAg-negative chronic hepatitis B: a meta-analysis
  publication-title: Gut
  doi: doi:10.1136/gutjnl-2020-323979
– volume: 16
  start-page: 567
  issue: 4
  year: 2022
  end-page: 574
  ident: bib158
  article-title: Risk of hepatitis B virus (HBV) reactivation in patients with immune-mediated inflammatory diseases receiving biologics: focus on the timing of biologics after anti-HBV treatment
  publication-title: Gut Liver
  doi: doi:10.5009/gnl210204
– volume: 21
  start-page: 567
  issue: 1
  year: 2021
  ident: bib187
  article-title: Short-term and long-term safety and efficacy of tenofovir alafenamide, tenofovir disoproxil fumarate and entecavir treatment of acute-on-chronic liver failure associated with hepatitis B
  publication-title: BMC Infect Dis
  doi: doi:10.1186/s12879-021-06237-x
– volume: 76
  start-page: 959
  issue: 4
  year: 2022
  end-page: 974
  ident: bib80
  article-title: Baveno VII-renewing consensus in portal hypertension
  publication-title: J Hepatol
  doi: doi:10.1016/j.jhep.2021.12.022
– volume: 50
  start-page: 482
  issue: 5
  year: 2018
  end-page: 489
  ident: bib62
  article-title: A novel noninvasive index for the prediction of moderate to severe fibrosis in chronic hepatitis B patients
  publication-title: Dig Liver Dis
  doi: doi:10.1016/j.dld.2017.12.028
– volume: 30
  start-page: 367
  issue: 4
  year: 2022
  end-page: 388
  ident: bib189
  article-title: Standard for diagnosis and treatment of primary liver cancer (2022 edition)
  publication-title: Zhonghua Gan Zang Bing Za Zhi
  doi: doi:10.3760/cma.j.cn115610-20220124-00053
– volume: 58
  start-page: 546
  issue: 2
  year: 2013
  end-page: 554
  ident: bib99
  article-title: Prediction models of long-term cirrhosis and hepatocellular carcinoma risk in chronic hepatitis B patients: risk scores integrating host and virus profiles
  publication-title: Hepatology
  doi: doi:10.1002/hep.26385
– volume: 61
  start-page: 1754
  issue: 12
  year: 2012
  end-page: 1764
  ident: bib44
  article-title: Innate and adaptive immune responses in chronic hepatitis B virus infections: towards restoration of immune control of viral infection
  publication-title: Gut
  doi: doi:10.1136/gutjnl-2011-301073
– volume: 66
  start-page: 398
  issue: 2
  year: 2017
  end-page: 411
  ident: bib45
  article-title: The role of quantitative hepatitis B surface antigen revisited
  publication-title: J Hepatol
  doi: doi:10.1016/j.jhep.2016.08.009
– volume: 121
  start-page: 3631
  issue: 20
  year: 2015
  end-page: 3638
  ident: bib117
  article-title: Impact of long-term tenofovir disoproxil fumarate on incidence of hepatocellular carcinoma in patients with chronic hepatitis B
  publication-title: Cancer
  doi: doi:10.1002/cncr.29537
– volume: 36
  start-page: 1291
  issue: 5
  year: 2021
  end-page: 1299
  ident: bib69
  article-title: Prognostic value of anti-HBc quantification in hepatitis B virus related acute-on-chronic liver failure
  publication-title: J Gastroenterol Hepatol
  doi: doi:10.1111/jgh.15310
– volume: 18
  start-page: 2582
  issue: 11
  year: 2020
  end-page: 2591.e6
  ident: bib153
  article-title: Persistent low level of hepatitis B virus promotes fibrosis progression during therapy
  publication-title: Clin Gastroenterol Hepatol
  doi: doi:10.1016/j.cgh.2020.03.001
– volume: 347
  start-page: f4503
  year: 2013
  ident: bib7
  article-title: The next step in controlling HBV in China
  publication-title: BMJ
  doi: doi:10.1136/bmj.f4503
– volume: 70
  start-page: 25
  issue: 1
  year: 2019
  end-page: 39
  ident: bib41
  article-title: Characteristics of impaired dendritic cell function in patients with hepatitis B virus infection
  publication-title: Hepatology
  doi: doi:10.1002/hep.30637
– volume: 14
  start-page: 105
  issue: 1
  year: 2020
  end-page: 114
  ident: bib126
  article-title: Tenofovir versus entecavir in lowering the risk of hepatocellular carcinoma development in patients with chronic hepatitis B: a critical systematic review and meta-analysis
  publication-title: Hepatol Int
  doi: doi:10.1007/s12072-019-10005-0
– volume: 346
  start-page: f3893
  year: 2013
  ident: bib101
  article-title: Diagnosis and management of chronic hepatitis B in children, young people, and adults: summary of NICE guidance
  publication-title: BMJ
  doi: doi:10.1136/bmj.f3893
– volume: 74
  start-page: 850
  issue: 4
  year: 2021
  end-page: 859
  ident: bib150
  article-title: Screening is associated with a lower risk of hepatocellular carcinoma-related mortality in patients with chronic hepatitis B
  publication-title: J Hepatol
  doi: doi:10.1016/j.jhep.2020.11.023
– volume: 77
  start-page: 1564
  issue: 6
  year: 2022
  end-page: 1572
  ident: bib94
  article-title: Validation of Baveno VII criteria for recompensation in entecavir-treated patients with hepatitis B-related decompensated cirrhosis
  publication-title: J Hepatol
  doi: doi:10.1016/j.jhep.2022.07.037
– volume: 44
  start-page: 217
  issue: 1
  year: 2006
  end-page: 231
  ident: bib92
  article-title: Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies
  publication-title: J Hepatol
  doi: doi:10.1016/j.jhep.2005.10.013
– volume: 17
  start-page: 1348
  issue: 7
  year: 2019
  end-page: 1355.e2
  ident: bib119
  article-title: Long-term efficacy of tenofovir disoproxil fumarate monotherapy for multidrug-resistant chronic HBV infection
  publication-title: Clin Gastroenterol Hepatol
  doi: doi:10.1016/j.cgh.2018.10.037
– volume: 77
  start-page: 42
  issue: 1
  year: 2022
  end-page: 54
  ident: bib144
  article-title: End-of-treatment HBcrAg and HBsAb levels identify durable functional cure after peg-IFN-based therapy in patients with CHB
  publication-title: J Hepatol
  doi: doi:10.1016/j.jhep.2022.01.021
– volume: 24
  start-page: 738
  issue: 10
  year: 2016
  end-page: 743
  ident: bib172
  article-title: A retrospective study on HBsAg clearance rate after antiviral therapy in children with HBeAg-positive chronic hepatitis B aged 1-7 years
  publication-title: Zhonghua Gan Zang Bing Za Zhi
  doi: doi:10.3760/cma.j.issn.1007-3418.2016.10.005
– volume: 44
  start-page: 16
  issue: 1
  year: 2016
  end-page: 34
  ident: bib177
  article-title: Review article: long-term safety of nucleoside and nucleotide analogues in HBV-monoinfected patients
  publication-title: Aliment Pharmacol Ther
  doi: doi:10.1111/apt.13659
– volume: 213
  start-page: 1096
  issue: 7
  year: 2016
  end-page: 1106
  ident: bib58
  article-title: Hepatitis B virus (HBV) core-related antigen during nucleos(t)ide analog therapy is related to intra-hepatic HBV replication and development of hepatocellular carcinoma
  publication-title: J Infect Dis
  doi: doi:10.1093/infdis/jiv572
– volume: 28
  start-page: 129
  issue: 2
  year: 2020
  end-page: 132
  ident: bib179
  article-title: Highlights of the guidelines of prevention and treatment for hepatitis C (2019 version)
  publication-title: Zhonghua Gan Zang Bing Za Zhi
  doi: doi:10.3760/cma.j.issn.1007-3418.2020.02.005
– volume: 53
  start-page: 774
  issue: 3
  year: 2011
  end-page: 780
  ident: bib186
  article-title: Tenofovir improves the outcome in patients with spontaneous reactivation of hepatitis B presenting as acute-on-chronic liver failure
  publication-title: Hepatology
  doi: doi:10.1002/hep.24109
– volume: 22
  start-page: 863
  issue: 1
  year: 2022
  ident: bib16
  article-title: A booster hepatitis B vaccine for children with maternal HBsAg positivity before 2 years of age could effectively prevent vaccine breakthrough infections
  publication-title: BMC Infect Dis
  doi: doi:10.1186/s12879-022-07854-w
– volume: 27
  start-page: 6053
  issue: 36
  year: 2021
  end-page: 6063
  ident: bib24
  article-title: Treatment of hepatitis B virus infection in children and adolescents
  publication-title: World J Gastroenterol
  doi: doi:10.3748/wjg.v27.i36.6053
– volume: 29
  start-page: 765
  issue: 9
  year: 2022
  end-page: 776
  ident: bib143
  article-title: Real-world study on HBsAg loss of combination therapy in HBeAg-negative chronic hepatitis B patients
  publication-title: J Viral Hepat
  doi: doi:10.1111/jvh.13722
– volume: 51
  start-page: e13575
  issue: 8
  year: 2021
  ident: bib191
  article-title: Immunoglobulin, nucleos(t)ide analogues and hepatitis B virus recurrence after liver transplant: a meta-analysis
  publication-title: Eur J Clin Invest
  doi: doi:10.1111/eci.13575
– volume: 71
  start-page: 616
  issue: 3
  year: 2022
  end-page: 626
  ident: bib19
  article-title: Hepatitis B virus integrations promote local and distant oncogenic driver alterations in hepatocellular carcinoma
  publication-title: Gut
  doi: doi:10.1136/gutjnl-2020-323153
– volume: 37
  start-page: 2033
  issue: 9
  year: 2021
  end-page: 2036
  ident: bib38
  article-title: Should chronic hepatitis B in the indeterminate phase be treated?
  publication-title: J Clin Hepatol
  doi: doi:10.3969/j.issn.1001- 5256.2021.09.007
– volume: 11
  start-page: 304
  issue: 2
  year: 2023
  end-page: 313
  ident: bib147
  article-title: An-Luo-Hua-Xian pill improves the regression of liver fibrosis in chronic hepatitis B patients treated with Entecavir
  publication-title: J Clin Transl Hepatol
  doi: doi:10.14218/JCTH.2022.00091
– volume: 17
  start-page: 182
  issue: 1
  year: 2019
  end-page: 191.e1
  ident: bib67
  article-title: Serum level of antibodies against hepatitis B core protein is associated with clinical relapse after discontinuation of nucleos(t)ide analogue therapy
  publication-title: Clin Gastroenterol Hepatol
  doi: doi:10.1016/j.cgh.2018.05.047
– volume: 20
  start-page: 1766
  issue: 8
  year: 2022
  end-page: 1775
  ident: bib103
  article-title: Treatment algorithm for managing chronic hepatitis B virus infection in the United States: 2021 update
  publication-title: Clin Gastroenterol Hepatol
  doi: doi:10.1016/j.cgh.2021.07.036
– volume: 156
  start-page: 384
  issue: 2
  year: 2019
  end-page: 399
  ident: bib21
  article-title: Insights from deep sequencing of the HBV genome-unique, tiny, and misunderstood
  publication-title: Gastroenterology
  doi: doi:10.1053/j.gastro.2018.07.058
– volume: 37
  start-page: 223
  issue: 2
  year: 2019
  end-page: 225
  ident: bib11
  article-title: Hepatitis B vaccines: WHO position paper, July 2017-recommendations
  publication-title: Vaccine
  doi: doi:10.1016/j.vaccine.2017.07.046
– volume: 21
  start-page: 197
  issue: 2
  year: 2015
  end-page: 203
  ident: bib63
  article-title: Quantitative hepatitis B core antibody levels in the natural history of hepatitis B virus infection
  publication-title: Clin Microbiol Infect
  doi: doi:10.1016/j.cmi.2014.10.002
– volume: 36
  start-page: 827
  issue: 6
  year: 2016
  end-page: 836
  ident: bib55
  article-title: Serum hepatitis B core-related antigen as a treatment predictor of pegylated interferon in patients with HBeAg-positive chronic hepatitis B
  publication-title: Liver Int
  doi: doi:10.1111/liv.13046
– volume: 75
  start-page: 659
  issue: 3
  year: 2021
  end-page: 689
  ident: bib75
  article-title: EASL clinical practice guidelines on non-invasive tests for evaluation of liver disease severity and prognosis-2021 update
  publication-title: J Hepatol
  doi: doi:10.1016/j.jhep.2021.05.025
– volume: 11
  start-page: 649
  issue: 3
  year: 2023
  end-page: 660
  ident: bib134
  article-title: 96-week treatment of tenofovir amibufenamide and tenofovir disoproxil fumarate in chronic hepatitis B patients
  publication-title: J Clin Transl Hepatol
  doi: doi:10.14218/JCTH.2022.00058
– volume: 28
  start-page: 601
  issue: 4
  year: 2021
  end-page: 612
  ident: bib29
  article-title: Durability of hepatitis B surface antigen seroclearance and subsequent risk for hepatocellular carcinoma: a meta-analysis
  publication-title: J Viral Hepat
  doi: doi:10.1111/jvh.13471
– volume: 14
  start-page: 1887
  issue: 9
  year: 2022
  ident: bib15
  article-title: HBx 128-133 deletion affecting HBV mother-to-child transmission weakens HBV replication via reducing HBx level and CP/ENII transcriptional activity
  publication-title: Viruses
  doi: doi:10.3390/v14091887
– volume: 76
  start-page: 196
  issue: 1
  year: 2022
  end-page: 206
  ident: bib20
  article-title: Quantified integrated hepatitis B virus is related to viral activity in patients with chronic hepatitis B
  publication-title: Hepatology
  doi: doi:10.1002/hep.32352
– volume: 13
  start-page: 372
  issue: 3
  year: 1991
  end-page: 374
  ident: bib85
  article-title: Classification of chronic viral hepatitis: a need for reassessment
  publication-title: J Hepatol
  doi: doi:10.1016/0168-8278(91)90084-o
SSID ssj0013724
Score 2.7075033
Snippet Abstract To facilitate the achieving of the goal of "eliminating viral hepatitis as a major public health threat by 2030" set by the World Health Organization,...
To facilitate the achieving of the goal of “eliminating viral hepatitis as a major public health threat by 2030” set by the World Health Organization, the...
SourceID doaj
wolterskluwer
SourceType Open Website
Publisher
StartPage 145
Title Guidelines for the Prevention and Treatment of Chronic Hepatitis B (Version 2022)
URI https://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&DO=10.1097/ID9.0000000000000098
https://doaj.org/article/2e1b29e1c48d46d1a3b2293632e3a5ce
Volume 3
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3PS8MwGA0yQRQRf-L8MXLwoIeyNWma5Ojc5hSmCJvsVpImARFacR3--37pjzG9eLHH9tDyvdL30u_lfQhdqdBRakwc8FiSwAdyBVrQKPBkL5kCxi2TmCZP8XgWPc7ZfG3Ul_eEVfHAVeG6xIaaSBumkTBRbEJFNQGKiimxVLHU-q8vcF6zmGr6B5xEq2GtIJmbTXOSdx8GsgotXB1S1IH9O2j3K_dN6sV76VFfY5rRPtqrJSK-rR7tAG3Y7BBtTeom-BF6uV_6bCrvV8cgOTFIONwkMeUZVpnB08Y-jnOH6_xbPLbePV28LXAfX9f_yTABdr05RrPRcHo3DurJCIEBiS8CTrSMtDIgNpgzPc2Iio0Ddk8VExwuKK1SZ0PBqRAOFg2EWR0DmXMFgsgReoJaWZ7ZU4R7PnBeQ0EZSyOnvVySVPFQGUdATKo26vvSJB9V-EXi46jLEwBSUoOU_AVSG4U_CptUmzyTpgMOmCS_MTn7jxufo20_H75y312gVvG5tJegIgrdKV-YDtp8fh0OB98aab-a
linkProvider Directory of Open Access Journals
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnZ3Lb9QwEIdHZStBEUK8KsrTB7SCQ9DGjp3kkEO7m3ZbulvQbks5RXZsI0BKqu4W_n1m8igPiQu5OEqUHGwn89kz8xuAVzr0QlirglilPCBBrsAkIgrI2KdSo8VtlJhmczU9jY7O5fkGfO1zYSj7bHXxlprmP00nVA-HFobL7GgxnOcfF1k1HC_G2afh-92DvNmnpiiJ4SSrv3tsTrJemvFwkrYChddHmtyATSV5PBrA5slZnk9--RxiHl0XeEXM7hPt_vGeTuT_Ntz5UZNje_WtiWv_zTrt34O7HVay3XYe3IcNVz2Am7POcf4QPhxckZ4VxbgzxFSG2Md69aa6YrqybNmHnLPas04zl00dRVyvv6zYHnvd7a0xjhb5zSM43c-X42nQVVMILC4LkiDmJo2Mtggo0tuRkVwr65EISi2TGG9oo0vvwiQWSeJxocGlMwoBINYIUZ6LbRhUdeUeAxuRSL1JhZKyjLwhxEqFjkNtPUcA1TuwR11TXLSCGQVJWDcX6svPRfdFFNyFhqcuLKPERsqGWhiO7KEEd0LL0u1A-EfHFm1iaNF7zXFMir_H5Ml_PPMSbk2Xs-Pi-HD-7ilsUTn5NljvGQzWl1fuOULH2rzoZstPdEHJSg
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB6VrVSBEOIpytMHFMEhaGPHjnPIod1kuy10W7RbWk6RHdtVhZRU3S2If884j_KQuJBLIkfJwZ5kvvF88w3AGxU5xowRYSJSGnpBrlBLFofe2adcocdtlZgO52J2Eh-c8bMNGKhDvvhsdfnen9rftL_w7XB8XLjMDhbBZDHJvgTz4nSRzYPjnb2i3ab2JIngOJ9mP4I8a765dZAfZYM-436ediqFN0cqb8GmlGIcj2Dz6HNR5L8SDwmNb7q8ItYequ3-8Z5e6f8O3P3e-Oz26mtLbv_NRU3vw70eW5KdzhgewIatH8LWYZ89fwSf9q69qJUnuhPEqgSxHxkknJqaqNqQ5cA7J40jvXAumVlPu15frMguedtvsBGKbvndYziZFsvJLOxbKoQGYwMZJlSnsVYGUQp3Zqw5VcI4hAWV4jLBG0qrytlIJkxKh9EG5VYLRAGJQiTlKHsCo7qp7VMgY69Ur1MmOK9ipz3OSplKImUcRRSqtmHXT0152almlF7Huh1ors7L_rMoqY00TW1UxdLEwkSKaYoARDBqmeKV3Yboj4ktu-rQckid45qUf6_Js_945jVsofmUH_fnH57Dbd9SviPsvYDR-uravkTgsdavemP5CR7nyhw
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Guidelines+for+the+Prevention+and+Treatment+of+Chronic+Hepatitis+B+%28Version+2022%29&rft.jtitle=Medicine+%28Baltimore%29&rft.au=Hong+You&rft.au=Fu-Sheng+Wang&rft.au=Taisheng+Li&rft.au=Xiaoyuan+Xu&rft.date=2023-10-01&rft.pub=Wolters+Kluwer&rft.issn=0025-7974&rft.eissn=1536-5964&rft.volume=3&rft.issue=4&rft.spage=145&rft.epage=162&rft_id=info:doi/10.1097%2FID9.0000000000000098&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_2e1b29e1c48d46d1a3b2293632e3a5ce
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0025-7974&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0025-7974&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0025-7974&client=summon