FOXP3 gene expression in multiple sclerosis patients pre- and post mesenchymal stem cell therapy

• Published in: Iranian journal of allergy, asthma, and immunology Vol. 10; no. 3; p. 155
• Main Authors: Mohajeri, Maryam, Farazmand, Ali, Mohyeddin Bonab, Mandana, Nikbin, Behrooz, Minagar, Alireza
• Format: Journal Article
• Language: English
• Published: Iran Tehran University of Medical Sciences 01.09.2011
• Subjects: Adult; Female; Forkhead Transcription Factors - genetics; Gene Expression Profiling; Humans; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells (MSC); Middle Aged; Multiple Sclerosis (MS); Multiple Sclerosis, Relapsing-Remitting - genetics; Multiple Sclerosis, Relapsing-Remitting - surgery; Pilot Projects; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - analysis; T Regulatory Cells (Treg); Transcription Factor (FOXP3)

Multiple Sclerosis (MS) is an inflammatory demyelinating and neurodegenerative disorder of the central nervous system (CNS), which mainly affects young adults. Activated T lymphocytes promote the neuro-inflammatory cascade of MS by secreting pro-inflammatory cytokines and play a significant role in...