Expanding tracer space for positron emission tomography with high molar activity 18F-labeled α,α-difluoromethylalkanes

• Published in: Nature communications Vol. 16; no. 1; pp. 1608 - 10
• Main Authors: Zhao, Qunchao, Telu, Sanjay, Lu, Shuiyu, Pike, Victor W.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 13.02.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 140/131; 140/58; 639/638/403/933; 639/638/549/933; Bioactive compounds; Cyclotrons; Drug development; Fluorine; Fluorine isotopes; Humanities and Social Sciences; Medical imaging; multidisciplinary; Positron emission; Positron emission tomography; Radioactive tracers; Science; Science (multidisciplinary); Tomography

Positron emission tomography (PET) is an advanced biomedical imaging modality that relies on well-designed radiotracers to report on specific protein targets and processes occurring in living animals and humans. Cyclotron-produced short-lived fluorine-18 ( t 1/2  = 109.8 min) is widely used to radio...