STIM1 Ca2+ Sensor Control of L-type Ca2+-Channel-Dependent Dendritic Spine Structural Plasticity and Nuclear Signaling

• Published in: Cell reports (Cambridge) Vol. 19; no. 2; pp. 321 - 334
• Main Authors: Dittmer, Philip J., Wild, Angela R., Dell’Acqua, Mark L., Sather, William A.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 11.04.2017; Elsevier
• Subjects: cytoplasmic Ca2; dendritic spine; endoplasmic reticulum; glutamate; L-type Ca2+ channel; N-methyl-D-aspartate receptor; nuclear factor of activated T cells; stromal interaction molecule 1; structural plasticity; voltage-gated Ca2+ channel; structural plasticity; nuclear factor of activated T cells; cytoplasmic Ca2; N-methyl-D-aspartate receptor; dendritic spine; voltage-gated Ca2+ channel; stromal interaction molecule 1; L-type Ca2+ channel; endoplasmic reticulum; glutamate

Potentiation of synaptic strength relies on postsynaptic Ca2+ signals, modification of dendritic spine structure, and changes in gene expression. One Ca2+ signaling pathway supporting these processes routes through L-type Ca2+ channels (LTCC), whose activity is subject to tuning by multiple mechanis...