AQP4 Aggravates Cognitive Impairment in Sepsis‐Associated Encephalopathy through Inhibiting Nav1.6‐Mediated Astrocyte Autophagy

• Published in: Advanced science Vol. 10; no. 14
• Main Authors: Zhu, Dan‐Dan, Huang, Yue‐Lin, Guo, Song‐Yu, Li, Na, Yang, Xue‐Wei, Sui, Ao‐Ran, Wu, Qiong, Zhang, Yue, Kong, Yue, Li, Qi‐Fa, Zhang, Ting, Zheng, Wen‐Fei, Li, Ai‐Ping, Yu, Jian, Ma, Tong‐Hui, Li, Shao
• Format: Journal Article
• Language: English
• Published: Weinheim John Wiley & Sons, Inc 01.05.2023; John Wiley and Sons Inc; Wiley
• Subjects: Alzheimer's disease; AQP4; astrocyte; Autophagy; Biomarkers; Cytokines; Health care; Mortality; Nervous system; neuroinflammation; Neurons; Patients; Proteins; Sepsis; sepsis‐associated encephalopathy; sodium channel Nav1.6; Traumatic brain injury; Tumor necrosis factor-TNF

The pathology of sepsis‐associated encephalopathy (SAE) is related to astrocyte‐inflammation associated with aquaporin‐4 (AQP4). The aim here is to investigate the effects of AQP4 associated with SAE and reveal its underlying mechanism causing cognitive impairment. The in vivo experimental results r...