Synthesis of Bispidine-Based Prostate-Specific Membrane Antigen-Targeted Conjugate and Initial Investigations

• Published in: Organics (Basel) Vol. 6; no. 1; p. 7
• Main Authors: Machulkin, Aleksei E, Petrov, Stanislav A, Kraynova, Maria D, Garanina, Anastasiia S, Egorova, Bayirta V, Timoshenko, Roman V, Vaneev, Alexander N, Erofeev, Alexander S, Priselkova, Anna B, Kalinin, Mikhail A, Aleksei V Medved′ko, Kalmykov, Stepan N, Beloglazkina, Elena K, Vatsadze, Sergey Z
• Format: Journal Article
• Language: English
• Published: Leuven MDPI AG 01.03.2025
• Subjects: Antigens; bispidine bifunctional chelator; Chromatography; complexation; Copper; copper-64; delivery; Ligands; Nuclear medicine; Prostate cancer; PSMA; United States > US; Japan

Nowadays, PSMA ligands are widely used for radiotheragnostic purposes in prostate cancer. The synthesis of a PSMA-Bisp conjugate was developed and realized with good yield (overall yield ~58% for the last two steps). All newly synthesized compounds were characterized by physicochemical methods: 1H a...