Metformin prevents oxidative stress and apoptosis of ovarian granulosa cells in polycystic ovary syndrome via activation of Nrf2-HO-1 pathway - Li, Jin-Jing; Wu, Hong-Lian; Lv, Yang; Qin, Ye-Min; Qiu, Xi-Xi; Cai, Xi-Xi (Gynecological endocrinology, 2025)
Keywords: Animals; apoptosis; Apoptosis - drug effects; Dehydroepiandrosterone; Disease Models, Animal; Female; granulosa cells; Granulosa Cells - drug effects; Granulosa Cells - metabolism; Heme Oxygenase (Decyclizing) - metabolism; Heme Oxygenase-1 - metabolism; Hypoglycemic Agents - pharmacology; metformin; Metformin - pharmacology; Metformin - therapeutic use; NF-E2-Related Factor 2 - metabolism; oxidative stress; Oxidative Stress - drug effects; Polycystic ovary syndrome; Polycystic Ovary Syndrome - drug therapy; Polycystic Ovary Syndrome - metabolism; Polycystic Ovary Syndrome - pathology; Rats; Rats, Sprague-Dawley; Signal Transduction - drug effects; Polycystic ovary syndrome; apoptosis; metformin; granulosa cells; oxidative stress