The clinical aspects of efficiency of the prevention of pneumococcal infection with vaccines in chronic obstructive pulmonary disease patients living in the West Siberian Region

• Published in: Terapevtic̆eskii arhiv Vol. 86; no. 3; pp. 28 - 33
• Main Authors: Kostinov, M P, Ryzhov, A A, Magarshak, O O, Zhirova, S N, Protasov, A D, Erofeev, Iu V, Migunova, O V, Tolokonnikova, I N, Liverko, E V
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) "Consilium Medicum" Publishing house 01.01.2014
• Subjects: Adult; Aged; chronic obstructive pulmonary disease; clinical efficacy; Disease Progression; Female; Hospitalization - statistics & numerical data; Humans; Male; Medical History Taking; Middle Aged; Outcome Assessment (Health Care); Physical Examination - methods; pneumo 23 vaccine; Pneumococcal Infections - epidemiology; Pneumococcal Infections - prevention & control; Pneumococcal Vaccines - therapeutic use; Pulmonary Disease, Chronic Obstructive - diagnosis; Pulmonary Disease, Chronic Obstructive - epidemiology; Pulmonary Disease, Chronic Obstructive - physiopathology; Qualitative Research; Siberia - epidemiology; Vaccination - methods; Vaccination - statistics & numerical data; Siberia
• ISSN: 0040-3660; 2309-5342

To evaluate the impact of vaccination against pneumococcal infection on the clinical aspects of the underlying disease in patients with chronic obstructive pulmonary disease (COPD). The study conducted in the West Siberian Region (Omsk and Tyumen) enrolled 200 COPD patients aged 30 to 55 years, of whom 50 people in each city were vaccinated with Pneumo 23, as well as 50 unvaccinated persons in each city formed a comparison group. Physical examination, questionnaire survey, and medical history data collection were made during a year before vaccination and after it. Changes in the number of COPD exacerbations, hospital admissions, and disability days were compared in the groups of Pneumo 23-vaccinated and unvaccinated patients. In Pneumo 23-vaccinated patients with COPD, the number of its exacerbations, hospital admissions, and disability days within a year of starting the study were fewer than in the unvaccinated patients, with the more effect being seen in the Omsk dwellers, which had a beneficial effect on the clinical state of the vaccinated. Incorporation of pneumococcal vaccine along with antirecurrent, standard therapy may serve as one of the tools to alleviate COPD.