Analysis of the modifying effects of TAP 1/2 genes on cystic fibrosis phenotype

• Published in: Turkish journal of pediatrics Vol. 44; no. 2; p. 91
• Main Authors: Ozbaş-Gerçeker, Filiz, Ozçelik, Uğur, Kiper, Nural, Anadol, Deniz, Ayhan, Göçmen, Yilmaz, Engin, Erdem-Yurter, Hayat, Ozgüç, Meral
• Format: Journal Article
• Language: English
• Published: Turkey Hacettepe University Institute of Child Health 01.04.2002
• Subjects: Adolescent; ATP-Binding Cassette Sub-Family B Member 2; ATP-Binding Cassette Transporters - genetics; ATP-Binding Cassette, Sub-Family B, Member 3; Child; Child, Preschool; Cystic Fibrosis - epidemiology; Cystic Fibrosis - genetics; Female; Gene Frequency; Genotype; Humans; Male; Phenotype; Polymerase Chain Reaction - methods; Polymorphism, Genetic; Turkey - epidemiology

Phenotypic variability has been reported in cystic fibrosis (CF) patients. TAP1 and TAP2 genes are encoding "the transporter associated with antigen processing" proteins. The aim of the present study was to analyze the frequency of TAP 1/2 variants in the Turkish population and to investig...