Overcoming drug resistance of cancer cells by targeting the FGF1/FGFR1 axis with honokiol or FGF ligand trap

• Published in: Frontiers in pharmacology Vol. 15; p. 1459820
• Main Authors: Szymczyk, Jakub, Sochacka, Martyna, Biadun, Martyna, Sluzalska, Katarzyna Dominika, Witkowska, Danuta, Zakrzewska, Malgorzata
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 12.09.2024
• Subjects: cancer; drug resistance; FGF1; FGFR1; honokiol; ligand trap; Pharmacology; ligand trap; honokiol; taltobulin; cancer; anti-cancer drugs; drug resistance; FGF1; FGFR1

Chemoresistance of cancer cells, resulting from various mechanisms, is a significant obstacle to the effectiveness of modern cancer therapies. Targeting fibroblast growth factors (FGFs) and their receptors (FGFRs) is becoming crucial, as their high activity significantly contributes to cancer develo...