Status of indoleamine-2,3-dioxygenase 1 in infiltrating ductal carcinoma of breast cancer: a new prognostic indicator for aggressive tumors

The tryptophan pathway has been demonstrated to be involved in tumorprogression. Increased expression of indoleamine 2,3-dioxygenases has been observed in several humantumors types, such as breast cancer. In order to study the role of IDO expression as a prognosticmarker, the serum tryptophan and ky...

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Bibliographic Details
Published inWorld cancer research journal Vol. 8
Main Authors Salmi, T., Dali-Sahi, M., Guermouche, B., Dennouni-Medjati, N., Hennart, Benjamin, Lenski, Marie, Allorge, Delphine
Format Journal Article
LanguageEnglish
Published Verduci Editore 01.01.2021
SeriesWorld Cancer Research journal
Subjects
biomarkers
infiltrating ductal carcinoma
kynurenine
Life Sciences
tryptophan
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ISSN2372-3416
2372-3416
DOI10.32113/wcrj_20219_2098

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Summary:The tryptophan pathway has been demonstrated to be involved in tumorprogression. Increased expression of indoleamine 2,3-dioxygenases has been observed in several humantumors types, such as breast cancer. In order to study the role of IDO expression as a prognosticmarker, the serum tryptophan and kynurenine concentrations and the ratio of kynurenine to tryptophan(K/T) of 165 subjects were compared, and correlations were established.
ISSN:2372-3416
2372-3416
DOI:10.32113/wcrj_20219_2098