Bioengineering liver microtissues for modeling non-alcoholic fatty liver disease

• Published in: EXCLI journal Vol. 22; pp. 367 - 391
• Main Authors: Negar Aasadollahei, Niloufar Rezaei, Reihaneh Golroo, Tarun Agarwal, Massoud Vosough, Abbas Piryaei
• Format: Journal Article
• Language: English
• Published: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund 01.03.2023
• Subjects: bioengineering; in vitro modeling; liver microtissue; liver organoid; non-alcoholic fatty liver disease; organ-on-a-chip

Non-alcoholic fatty liver disease (NAFLD) has become the world’s most common chronic liver disease. However, due to the lack of reliable in vitro NAFLD models, drug development studies have faced many limitations, and there is no food and drug administration-approved medicine for NAFLD treatment. A...