Progress of Liquid Biopsy in the Diagnosis and Treatment of Lung Cancer with Malignant Pleural Effusion
Lung cancer is the malignancy with the highest mortality rate worldwide. Malignant pleural effusion (MPE) caused by advanced lung cancer severely affects the quality of life and prognosis of patients. Tumor-associated genetic testing is the basis for making precise treatment decisions. There are som...
Saved in:
Published in | Zhongguo fei ai za zhi Vol. 24; no. 9; pp. 653 - 659 |
---|---|
Main Authors | , , |
Format | Journal Article |
Language | Chinese |
Published |
China
Chinese Anti-Cancer Association Chinese Antituberculosis Association
20.09.2021
Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Lung cancer is the malignancy with the highest mortality rate worldwide. Malignant pleural effusion (MPE) caused by advanced lung cancer severely affects the quality of life and prognosis of patients. Tumor-associated genetic testing is the basis for making precise treatment decisions. There are some risks of tissue biopsy, and it is difficult to sample repeatedly. Due to its non-invasive and can reflect the full profile of tumor gene characteristics, liquid biopsy is increasingly used in the diagnosis and treatment of lung cancer. Because of the extremely low DNA level of circulating tumor, the sensitivity and specificity of liquid biopsy based on blood samples are limited. Tumor cells is enriched in MPE. The detection of cell-free DNA, extracellular vesicles and microRNA in MPE will be helpful to the diagnose, treatment and assess prognosis of patients with lung cancer. This review aims to discuss the research progress of liquid biopsy based on MPE in the diagnosis and treatment of lung cancer patients.
. |
---|---|
AbstractList | Lung cancer is the malignancy with the highest mortality rate worldwide. Malignant pleural effusion (MPE) caused by advanced lung cancer severely affects the quality of life and prognosis of patients. Tumor-associated genetic testing is the basis for making precise treatment decisions. There are some risks of tissue biopsy, and it is difficult to sample repeatedly. Due to its non-invasive and can reflect the full profile of tumor gene characteristics, liquid biopsy is increasingly used in the diagnosis and treatment of lung cancer. Because of the extremely low DNA level of circulating tumor, the sensitivity and specificity of liquid biopsy based on blood samples are limited. Tumor cells is enriched in MPE. The detection of cell-free DNA, extracellular vesicles and microRNA in MPE will be helpful to the diagnose, treatment and assess prognosis of patients with lung cancer. This review aims to discuss the research progress of liquid biopsy based on MPE in the diagnosis and treatment of lung cancer patients.
. 肺癌是全球范围内死亡率最高的恶性肿瘤。晚期肺癌所致的恶性胸腔积液(malignant pleural effusion, MPE)严重影响患者的生活质量和预后。针对肿瘤的基因检测是制定精准治疗决策的基础,而组织活检取材存在风险,难以反复多次取样。液体活检由于具有无创性和可以反映肿瘤基因全貌的特点,在肺癌诊疗中的应用日益增多。基于血液样本的液体活检由于循环肿瘤DNA的含量极低,灵敏度和特异度有限。MPE中富含肿瘤细胞,检测其中的细胞游离DNA、细胞外囊泡和微小RNA等将有助于肺癌的诊断、治疗及预后的评估。本综述将探讨胸腔积液作为活检样本的研究,阐述液体活检在肺癌伴MPE诊疗中的研究进展。 Lung cancer is the malignancy with the highest mortality rate worldwide. Malignant pleural effusion (MPE) caused by advanced lung cancer severely affects the quality of life and prognosis of patients. Tumor-associated genetic testing is the basis for making precise treatment decisions. There are some risks of tissue biopsy, and it is difficult to sample repeatedly. Due to its non-invasive and can reflect the full profile of tumor gene characteristics, liquid biopsy is increasingly used in the diagnosis and treatment of lung cancer. Because of the extremely low DNA level of circulating tumor, the sensitivity and specificity of liquid biopsy based on blood samples are limited. Tumor cells is enriched in MPE. The detecti |
Author | Li, Weimin Zeng, Hao Tian, Panwen |
Author_xml | – sequence: 1 givenname: Hao surname: Zeng fullname: Zeng, Hao organization: Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu 610041, China – sequence: 2 givenname: Panwen surname: Tian fullname: Tian, Panwen organization: Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu 610041, China – sequence: 3 givenname: Weimin surname: Li fullname: Li, Weimin organization: Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu 610041, China |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34256901$$D View this record in MEDLINE/PubMed |
BookMark | eNpd0ctu1DAUBmALFdELvAKyBAs2Cb5fljAUqDSILso68sTHqaOMPbUToe54nb5Wn4SoFxasfHz06Zet_xQdpZwAofeUtFxr-3FsY62ppYTYhgtqW0YYXa-0ZeIFOqHW2kZRo4_W-dkco9NaR0IUs1y8QsdcMKksoSdovCx5KFArzgFv480SPf4c86He4pjwfA34S3RDyjVW7JLHVwXcvIc0P_glDXjjUg8F3_-5-x3na_zDTXFIbgWXEyzFTfg8hKXGnF6jl8FNFd48nWfo19fzq833Zvvz28Xm07bxjJG5UVrKIDy3REoF3ATBg5VALNkZLl2gJiigxAoivA29loRowrjm3hkpec_P0MVjrs9u7A4l7l257bKL3cMil6FzZY79BF0w3AftqedKid5QJxkoDkbsKDPU7NasD49Zh5JvFqhzt4-1h2lyCfJSOyYllVozqlf67j865qWk9aer0latDTGxqrdPatntwf973nMj_C-1fpCn |
ContentType | Journal Article |
Copyright | Copyright © 2021. This work is published under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
Copyright_xml | – notice: Copyright © 2021. This work is published under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
DBID | CGR CUY CVF ECM EIF NPM ABUWG AFKRA AZQEC BENPR BVBZV CCPQU DWQXO PIMPY PQEST PQQKQ PQUKI PRINS 7X8 DOA |
DOI | 10.3779/j.issn.1009-3419.2021.101.24 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central East & South Asia Database ProQuest One Community College ProQuest Central Korea Publicly Available Content Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic Directory of Open Access Journals |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest Central ProQuest One Academic UKI Edition ProQuest Central Essentials ProQuest Central Korea ProQuest One Academic Eastern Edition ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Academic ProQuest Central China East & South Asia Database MEDLINE - Academic |
DatabaseTitleList | MEDLINE Publicly Available Content Database |
Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1999-6187 |
EndPage | 659 |
ExternalDocumentID | oai_doaj_org_article_f83df7d1d3664c81a52e63e84b12818b 34256901 |
Genre | Journal Article Review |
GroupedDBID | --- -05 04C 29R 2B. 2C~ 2WC 3V. 5GY 5VS 6PF 92F 92I AAWTL ABUWG ACGFS AFKRA ALMA_UNASSIGNED_HOLDINGS BENPR BPHCQ BVBZV CCEZO CCPQU CGR CIEJG CUY CVF CW9 DIK E3Z EBD ECM EIF EIHBH EMOBN EOJEC F5P GROUPED_DOAJ HYE KQ8 KWQ NPM OBODZ OK1 PIMPY PQQKQ PROAC RIG RNS RPM TCJ TGQ U1G U5O AZQEC DWQXO PGMZT PQEST PQUKI PRINS 7X8 |
ID | FETCH-LOGICAL-d220t-6755f4d390556e38f43f95e090b835af18f6e109404d9fc7500702373da8553c3 |
IEDL.DBID | BENPR |
ISSN | 1009-3419 |
IngestDate | Thu Jul 04 21:11:00 EDT 2024 Fri Aug 16 21:54:37 EDT 2024 Fri Sep 13 07:49:05 EDT 2024 Thu May 23 23:45:39 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 9 |
Keywords | Malignant pleural effusion Liquid biopsy Lung neoplasms |
Language | Chinese |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-d220t-6755f4d390556e38f43f95e090b835af18f6e109404d9fc7500702373da8553c3 |
Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
OpenAccessLink | https://www.proquest.com/docview/2579610124/abstract/?pq-origsite=%requestingapplication% |
PMID | 34256901 |
PQID | 2579610124 |
PQPubID | 2055412 |
PageCount | 7 |
ParticipantIDs | doaj_primary_oai_doaj_org_article_f83df7d1d3664c81a52e63e84b12818b proquest_miscellaneous_2551577217 proquest_journals_2579610124 pubmed_primary_34256901 |
PublicationCentury | 2000 |
PublicationDate | 2021-Sep-20 |
PublicationDateYYYYMMDD | 2021-09-20 |
PublicationDate_xml | – month: 09 year: 2021 text: 2021-Sep-20 day: 20 |
PublicationDecade | 2020 |
PublicationPlace | China |
PublicationPlace_xml | – name: China – name: Tianjin |
PublicationTitle | Zhongguo fei ai za zhi |
PublicationTitleAlternate | Zhongguo Fei Ai Za Zhi |
PublicationYear | 2021 |
Publisher | Chinese Anti-Cancer Association Chinese Antituberculosis Association Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
Publisher_xml | – name: Chinese Anti-Cancer Association Chinese Antituberculosis Association – name: Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
SSID | ssj0062934 ssib002262905 ssib044765436 ssib001103766 ssib038074678 ssib051369142 |
Score | 2.3121533 |
SecondaryResourceType | review_article |
Snippet | Lung cancer is the malignancy with the highest mortality rate worldwide. Malignant pleural effusion (MPE) caused by advanced lung cancer severely affects the... 肺癌是全球范围内死亡率最高的恶性肿瘤。晚期肺癌所致的恶性胸腔积液(malignant pleural effusion,... |
SourceID | doaj proquest pubmed |
SourceType | Open Website Aggregation Database Index Database |
StartPage | 653 |
SubjectTerms | Biopsy Humans liquid biopsy Liquid Biopsy - trends Lung cancer lung neoplasms Lung Neoplasms - complications Lung Neoplasms - pathology Lung Neoplasms - therapy malignant pleural effusion Medical diagnosis Pleural effusion Pleural Effusion, Malignant - etiology Pleural Effusion, Malignant - pathology Pleural Effusion, Malignant - therapy Quality of Life |
SummonAdditionalLinks | – databaseName: Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1NT9wwELUQB8Slakuh21JkpL1mN_6MfeRTCLEVB5C4RU5st0FVFtjdQznxd_hb_BJmkmzYC-qlh1wSJ3Kc58kbz8wzIcNg0xgD14nwDhwUn7rECCBymkcrbaG9MljgPPmpz67l-Y26WdnqC3PCWnngduDG0QgfM8-80FqWhjnFgxbByAJjQKZorC9TK85UQwSw_G3VMeGa2zdko8o6WIgeeVJmWGPZt1dMaMtkL0QFN7fxaQwloALaBhmiv5tldnzbzNZRfwl8Ts7QKR5x2W0E8D57bf5ipx_Jh45-0oP2tT-Rtcffn8nGpAuwb5HbS8zXAutHp5FeVPeLytPDano3-0urmgJZpMdtbl41o6729GqZp960B8NBjxBGD_Tl6RmXeOkEeP4vTLahl38CSnzQkxgXuET3hVyfnlwdnSXddgyJ5zydJ-BaqCi9sKi_E4SJUkSrQmrTAmici8xEHRjq8UlvYwlUBMwJFxmgwCglSrFN1utpHb4SWigemUM0lEJ6aRyQqMJHBocr4fEDcojjlt-1ihs5amA3JwAZeYeM_F_IGJDd5ajn3cSc5Rxrb1HTTA7Ifn8ZphTGSVwdpgtsAyQPvA6WDchO-7X6ngiwcbiH17f_0cPvZBPBguknPN0l6_OHRfgBHGde7DVwfgVZW-1S priority: 102 providerName: Directory of Open Access Journals |
Title | Progress of Liquid Biopsy in the Diagnosis and Treatment of Lung Cancer
with Malignant Pleural Effusion |
URI | https://www.ncbi.nlm.nih.gov/pubmed/34256901 https://www.proquest.com/docview/2579610124/abstract/ https://search.proquest.com/docview/2551577217 https://doaj.org/article/f83df7d1d3664c81a52e63e84b12818b |
Volume | 24 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9NAEF6VVqq4IN4ESrVIvbrxPr17QqSkihCpItRKvVlr724wQnaaxwF-PTO243CBQy722orsb8ffvL4h5CLYNMbAdSK8AwfFpy4xAoic5tFKW2ivDDY4z2_07E5-uVf3R2S274XBssq9TWwNtW9KjJGPOTZNohiVHLsCowDldvxx9ZDg_CjMs_bDNB6RE84kJmxPJtObxbcDNcCGuL9dFa65PWAdddfBZgxYlDLDrsthvWJCWyYHaSq4uMtYY3IBNdFOyQV6wFlmxz_a_Xs5nAIvlDN0ky-57EcD_JvPtt-166fkSU9I6acOQc_I0e_vz8npvE-5vyDLBVZwgT2kTaRfq4dd5emkalabX7SqKdBH-rmr1qs21NWe3u4r19v1YEroFQJrTTHiS-dA-5dYe0MXPwMqftBpjDuM2L0kd9fT26tZ0k9nSDzn6TYBT0NF6YVFOZ4gTJQiWhVSmxbA6lxkJurAUJ5PehtLYCZgXbjIABRGKVGKV-S4burwhtBC8cgcgqMU0kvjgFMVPjL4uRJuPyITfGj5qhPgyFESuz3QrJd5v8PyaISPmWdeaC1Lw5ziQYtgZIHJQlOMyNn-kef9Pt3kB1SNyIfhNOwwTJu4OjQ7XAOcD5wQlo3I6-5VDf9EgMnDkV5v_3_zd-QxYgDrTHh6Ro636114D2RmW5z3OD1vgwF_ADKt6Qc |
link.rule.ids | 315,786,790,870,2115,21416,27957,27958,33779,33780,43840,74659 |
linkProvider | ProQuest |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lj9MwELagKy1cVjyXwgJG2mt240cc-4To0lWBtqpQV9pblMR2KUJJt4_D8uuZSdyUCxxyiR0rcj5PvvGMvyHk3JnYe8dVJGwODoqN80gLIHKKeyNNoWyi8YDzZKpGN_LrbXIbNtw2Ia1ybxMbQ23rEvfILzkemkQxKvlxdRdh1SiMroYSGg_JkRTgqvTI0WA4nX0_EAI8Bve3g8IVNweEo9o6WIoOgVKmeNay658woQyTnSAVPNzGqTGkgEpox-Qc_d40NZc_m1V70TWB78kZOscXXIaCAP9msc3f7PoJOQk0lH5qcfOUPPj94xk5noRA-3OymGHeFlhBWns6Xt7tlpYOlvVqc0-XFQXSSD-3OXrLDc0rS-f7fPWmPxgQeoVwWlPc56UTIPsLzLihs18OdT7o0Psd7tO9IDfXw_nVKAo1GSLLebyNwL9IvLTCoAiPE9pL4U3iYhMXwOVyz7RXjqEon7TGl8BHwKZwkQIUdJKIUrwkvaqu3CtCi4R7liMkSiGt1DkwqcJ6BldewvB9MsBJy1at7EaGQtjNjXq9yMK6yrwW1qeWWaGULDXLE-6UcFoWGCLURZ-c7ac8C6tzkx2w1CcfumZYVxgsyStX77APMD1wPVjaJ6ftp-reRIChw0Jer_8_-HvyaDSfjLPxl-m3N-Qx4gEzTXh8Rnrb9c69BTqzLd4FzP4BCi7nRQ |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lj9MwELZgV6q4IN4UFjDSXrNN_Ip9QnS31QLbqkK70t6iJLa7QSjp9nGAX89M4qZc4JBL7FiR83nyjWf8DSGnzsTeO6YibnNwUGycR5oDkVPMG2EKZaXGA86zubq8EV9v5W3If9qEtMq9TWwNtW1K3CMfMTw0iWJUYuRDWsTiYvppdR9hBSmMtIZyGg_JcSqUBIQfjyfzxfcDOcAjcX87K0wxc0A7Kq-D1ejRKESK5y77_jLhyiSiF6eCh7uYNYYXUBVtQE7RB05TM_rRruCzvgn8UJago3zGRCgO8G9G2_7Zpk_I40BJ6ecOQ0_Jg993z8hgFoLuz8lygTlcYBFp4-lVdb-rLB1XzWrzi1Y1BQJJL7p8vWpD89rS633uetsfjAk9R2itKe750hkQ_yVm39DFT4eaH3Ti_Q737F6Qm-nk-vwyCvUZIstYvI3A15BeWG5QkMdx7QX3RrrYxAXwutwn2iuXoECfsMaXwE3AvjCeAiy0lLzkL8lR3dTuNaGFZD7JER4lF1boHFhVYX0CV17C8EMyxknLVp0ER4ai2O2NZr3MwhrLvObWpzaxXClR6iSXzCnutCgwXKiLITnZT3kWVuomO-BqSD72zbDGMHCS167ZYR9gfeCGJOmQvOo-Vf8mHIweFvV68__BP5ABwDW7-jL_9pY8Qjhg0gmLT8jRdr1z74DZbIv3AbJ_AJAU64I |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Progress+of+Liquid+Biopsy+in+the+Diagnosis+and+Treatment+of+Lung+Cancer+%E2%80%A9with+Malignant+Pleural+Effusion&rft.jtitle=Zhongguo+fei+ai+za+zhi&rft.au=Zeng%2C+Hao&rft.au=Tian%2C+Panwen&rft.au=Li%2C+Weimin&rft.date=2021-09-20&rft.eissn=1999-6187&rft.volume=24&rft.issue=9&rft.spage=653&rft_id=info:doi/10.3779%2Fj.issn.1009-3419.2021.101.24&rft_id=info%3Apmid%2F34256901&rft.externalDocID=34256901 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1009-3419&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1009-3419&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1009-3419&client=summon |