Expression of dystrophin-glycoprotein complex at the skeletal muscle sarcolemma in Duchenne muscular dystrophy

• Published in: Zhongguo xian dai shen jing ji bing za zhi Vol. 15; no. 6; pp. 448 - 452
• Main Authors: ZHAO, Lei, Chao-ping, HU, WANG, Yi, ZHOU, Shui-zhen, Yi-yun, SHI, Xi-hua, LI
• Format: Journal Article
• Language: Chinese; English
• Published: Tianjin Shi Tianjin Huanhu Hospital 25.06.2015
• Subjects: Athletic injuries; Dystrophin-associated protein complex; Muscular dystrophy; Muscular dystrophy, Duchenne; Musculoskeletal system

Background Eccentric exercise or high tension exercise could cause damage to skeletal muscle structure, resulting in deficiency of dystrophin and secondary loss of dystrophin-glycoprotein complex (DGC) from the sarcolemma, which indicated that down-regulation of dystrophin was one of the key points...