Clinical pathological characteristics and immune microenvironment significance of EGFR T790M mutation in non-small cell lung cancer patients and its prognostic implications

• Published in: Zhongguo ai zheng za zhi Vol. 34; no. 4; pp. 368 - 379
• Main Author: LIN Yicong, WANG Yue, XUE Qianqian, ZHENG Qiang, JIN Yan, HUANG Ziling, LI Yuan
• Format: Journal Article
• Language: Chinese; English
• Published: Editorial Office of China Oncology 01.04.2024
• Subjects: non-small cell lung cancer|egfr t790m mutation|egfr tki|immune microenvironment

Background and purpose: Epidermal growth factor receptor exon 20 T790M (EGFR T790M) mutation is one of the acquired resistance mechanisms in non-small cell lung cancer (NSCLC) against first-/second-generation EGFR tyrosine kinase inhibitors (EGFR TKIs). Additionally, EGFR T790M mutation can also be...