Papel emergente do eixo GH/IGF-I no controle cardiometabólico
O hormônio de crescimento (GH), principal regulador do crescimento pós-natal, tem importantes ações metabólicas em diferentes tecidos, sinérgicas ou até antagônicas às do fator de crescimento semelhante à insulina tipo I (IGF-I), produzido sobretudo no fígado após ligação do GH ao seu receptor. Expe...
Saved in:
| Published in | Arquivos brasileiros de cardiologia Vol. 97; no. 5; pp. 434 - 439 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English Portuguese |
| Published |
Sociedade Brasileira de Cardiologia - SBC
01.11.2011
Sociedade Brasileira de Cardiologia (SBC) |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | O hormônio de crescimento (GH), principal regulador do crescimento pós-natal, tem importantes ações metabólicas em diferentes tecidos, sinérgicas ou até antagônicas às do fator de crescimento semelhante à insulina tipo I (IGF-I), produzido sobretudo no fígado após ligação do GH ao seu receptor. Experimentos em modelos animais indicam um papel importante do GH na resistência a insulina, enquanto o papel do IGF-I nessa condição ainda não está completamente elucidado. Em humanos, o GH promove aumento da lipólise e da oxidação lipídica, enquanto o IGF-I desencadeia o aumento da oxidação lipídica apenas cronicamente. Enquanto as ações sobre o crescimento são tempo limitado, as ações metabólicas e cardiovasculares do eixo GH/IGF-I perduram durante toda a vida. Os potenciais efeitos anabólicos do GH têm sido utilizados em condições crônicas e hipercatabólicas, embora as investigações sobre os desfechos clínicos ainda sejam escassas. Neste artigo, pretendemos revisar as ações metabólicas do GH oriundas de modelos animais, os estudos em humanos normais e indivíduos com deficiência de GH, diabete melito tipo 1, síndrome metabólica, estados hipercatabólicos e a relação do eixo GH/IGF-I com as adipocinas, disfunção endotelial e aterogênese |
|---|---|
| AbstractList | O hormônio de crescimento (GH), principal regulador do crescimento pós-natal, tem importantes ações metabólicas em diferentes tecidos, sinérgicas ou até antagônicas às do fator de crescimento semelhante à insulina tipo I (IGF-I), produzido sobretudo no fígado após ligação do GH ao seu receptor. Experimentos em modelos animais indicam um papel importante do GH na resistência a insulina, enquanto o papel do IGF-I nessa condição ainda não está completamente elucidado. Em humanos, o GH promove aumento da lipólise e da oxidação lipídica, enquanto o IGF-I desencadeia o aumento da oxidação lipídica apenas cronicamente. Enquanto as ações sobre o crescimento são tempo limitado, as ações metabólicas e cardiovasculares do eixo GH/IGF-I perduram durante toda a vida. Os potenciais efeitos anabólicos do GH têm sido utilizados em condições crônicas e hipercatabólicas, embora as investigações sobre os desfechos clínicos ainda sejam escassas. Neste artigo, pretendemos revisar as ações metabólicas do GH oriundas de modelos animais, os estudos em humanos normais e indivíduos com deficiência de GH, diabete melito tipo 1, síndrome metabólica, estados hipercatabólicos e a relação do eixo GH/IGF-I com as adipocinas, disfunção endotelial e aterogênese |
| Author | Barreto-Filho, José A. S Oliveira, Carla R.P Meneguz-Moreno, Rafael A Aguiar-Oliveira, Manuel H |
| AuthorAffiliation | Universidade Federal de Sergipe |
| AuthorAffiliation_xml | – name: Universidade Federal de Sergipe |
| Author_xml | – sequence: 1 givenname: Carla R.P surname: Oliveira fullname: Oliveira, Carla R.P organization: Universidade Federal de Sergipe – sequence: 2 givenname: Rafael A surname: Meneguz-Moreno fullname: Meneguz-Moreno, Rafael A organization: Universidade Federal de Sergipe – sequence: 3 givenname: Manuel H surname: Aguiar-Oliveira fullname: Aguiar-Oliveira, Manuel H organization: Universidade Federal de Sergipe – sequence: 4 givenname: José A. S surname: Barreto-Filho fullname: Barreto-Filho, José A. S organization: Universidade Federal de Sergipe |
| BookMark | eNplkEtKA0EQQHsRwSR6BvsCk1T_ZzaCBJMMBBRUcNf09CdMmEyHnhH0XB7Bi9kk7txUQUE9Hm-GJn3sPUJ3BBZEVLB8AZCyUCV9p0AIAOGQB52gKZGqLDhRcI1mw3AAoFQxMUX3z-bkO-yPPu19P3rsIvbtZ8Sb7bLerIsa9xHb2I8pdh5bk1wbj340zc9319p4g66C6QZ_-7fn6G39-LraFrunTb162BWOgKAFl6bkRongKgIBWCNJlV1sCE3WI5JwZyyjLgiwjPGSCXClsJZzkKxRjM1RfeG6aA76lNqjSV86mlafDzHttUljazuvA2u8yP9BScqZqsqyqUSuAJxIaz3PrMWFNdjWd1Ef4kfqs7w-19P_6rFfOYNkbg |
| ContentType | Journal Article |
| Copyright | This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
| Copyright_xml | – notice: This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
| DBID | GPN DOA |
| DOI | 10.1590/S0066-782X2011001400012 |
| DatabaseName | SciELO Directory of Open Access Journals |
| DatabaseTitleList | |
| Database_xml | – sequence: 1 dbid: DOA name: Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| DocumentTitleAlternate | Emerging role of the GH/IGF-I on cardiometabolic control |
| EndPage | 439 |
| ExternalDocumentID | oai_doaj_org_article_f3be550df762437988b950010416cce4 S0066_782X2011001400012 |
| GroupedDBID | 23N 2WC 53G 5GY 5VS 6J9 ABXHO ACGFO ADBBV AENEX ALMA_UNASSIGNED_HOLDINGS APOWU AZFZN BAWUL BCNDV C1A CS3 DIK E3Z EBS EJD F5P GPN GROUPED_DOAJ GX1 IPNFZ KQ8 M~E OK1 P2P RIG RNS RPM RSC SCD TR2 XSB |
| ID | FETCH-LOGICAL-d1052-46a84a75fd910f03b619170cffb0121614dac32df50c3348350d85cc44063b733 |
| IEDL.DBID | DOA |
| ISSN | 1678-4170 |
| IngestDate | Tue Oct 22 15:08:50 EDT 2024 Fri Oct 18 20:44:58 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 5 |
| Keywords | insulin-like growth factor I grelina factor de crecimiento insulin-like I fator de crescimento insulin-like I Lypolisis ghrelin Lipólisis Lipólise resistência à insulina metabolismo metabolism insulin resistance resistencia a la insulina |
| Language | English Portuguese |
| License | This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. http://creativecommons.org/licenses/by-nc/4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-d1052-46a84a75fd910f03b619170cffb0121614dac32df50c3348350d85cc44063b733 |
| OpenAccessLink | https://doaj.org/article/f3be550df762437988b950010416cce4 |
| PageCount | 6 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_f3be550df762437988b950010416cce4 scielo_journals_S0066_782X2011001400012 |
| PublicationCentury | 2000 |
| PublicationDate | 20111101 2011-11-01 |
| PublicationDateYYYYMMDD | 2011-11-01 |
| PublicationDate_xml | – month: 11 year: 2011 text: 20111101 day: 01 |
| PublicationDecade | 2010 |
| PublicationTitle | Arquivos brasileiros de cardiologia |
| PublicationTitleAlternate | Arq. Bras. Cardiol |
| PublicationYear | 2011 |
| Publisher | Sociedade Brasileira de Cardiologia - SBC Sociedade Brasileira de Cardiologia (SBC) |
| Publisher_xml | – name: Sociedade Brasileira de Cardiologia - SBC – name: Sociedade Brasileira de Cardiologia (SBC) |
| References | Ho, KY; Veldhuis, JD; Jonson, ML; Furlanetto, R; Evans, WS; Alberti, KG 1988; 81 Di Cola, G; Cool, MH; Accili, D 1997; 99 Delafontaine, P; Song, YH; Li, Y 2004; 24 Oliveira, JL; Aguiar-Oliveira, MH; D'Oliveira Jr, A; Pereira, RM; Oliveira, CR; Farias, CT 2007; 92 Hew, FL; Koschmann, M; Christopher, M; Rantzau, C; Vaag, A; Ward, G 1996; 81 Beck, JC; McGarry, EE; Dyrenfurth, I; Venning, EH 1957; 125 Oliveira, CR; Salvatori, R; Meneguz-Moreno, RA; Aguiar-Oliveira, MH; Pereira, RM; Valença, EH 2010; 95 Raben, MS; Hollenberg, CH 1959; 38 Beltowski, J 2006; 189 Hardin, DS; Ellis, KJ; Dyson, M; Rice, J; McConnell, R; Seilheimer, DK 2001; 139 Herrington, J; Carter-Su, C 2001; 12 Gola, M; Bonadonna, S; Doga, M; Giustina, A 2005; 90 Pfeifer, M; Verhovec, R; Zizek, B; Prezely, J; Poredos, P; Clayton, RN 1999; 84 Haluzik, M; Yakar, S; Gavrilova, O; Setser, J; Boisclair, Y; LeRoith, D 2003; 52 Jung, CH; Lee, WY; Rhee, EJ; Kim, SY; Oh, KW; Yun, EJ 2006; 37 Yakar, S; Setser, J; Zhao, H; Stannard, B; Haluzik, M; Glatt, V 2004; 113 Mauras, N; Haymond, MW 2005; 15 Franco, C; Brandberg, J; Lonn, L; Andersson, B; Bengtsson, BA; Johannsson, G 2005; 90 Johansson, JO; Fowelin, J; Landin, K; Lager, I; Bengtsson, BA 1995; 44 Barreto-Filho, JA; Alcântara, MR; Salvatori, R; Barreto, MA; Sousa, AC; Bastos, V 2002; 87 Capaldo, B; Patti, L; Oliviero, U; Longobardi, S; Pardo, F; Vitale, F 1997; 82 Veldhuis, JD; Iranmanesh, A; Ho, KK; Waters, MJ; Johnson, ML; Lizarralde, G 1991; 72 Guo, Y; Lu, Y; Houle, D; Robertson, K; Tang, Z; Kopchick, JJ 2005; 146 Kanety, H; Hemi, R; Ginsberg, S; Pariente, C; Yissachar, E; Barhod, E 2009; 161 Mulligan, K; Tai, VW; Schambelan, M 1999; 23 Nilsson, L; Binart, N; Bohlooly, YM; Bramnert, M; Egecioglu, E; Kindblom, J 2005; 331 Liu, J; Coschigano, KT; Robertson, K; Lipsett, M; Guo, Y; Kopchick, JJ 2004; 287 Gleeson, H; Barreto, ES; Salvatori, R; Costa, L; Oliveira, CR; Pereira, RM 2007; 66 Haffner, D; Schaefer, F; Nissel, R; Wuhl, E; Tonshoff, B; Mehls, O 2000; 343 Fukuda, I; Hizuka, N; Ishikawa, Y; Itoh, E; Yasumoto, K; Murakami, Y 2004; 14 Brummer, RJ 1998; 8 Milani, SLS Nielsen, S; Møller, N; Christiansen, JS; Jørgensen, JO 2001; 50 de A Barretto, ES; Gill, MS; De Freitas, ME; Magalhães, MM; Souza, AH; Aguiar-Oliveira, MH 1999; 51 Verdecchia, P; Reboldi, G; Schillaci, G; Borgioni, C; Ciucci, A; Telera, MP 1999; 100 Sakharova, AA; Horowitz, JF; Surya, S; Goldenberg, N; Harber, MP; Symons, K 2008; 93 Davidson, MB 1987; 8 Oliveira, JL; Marques-Santos, C; Barreto-Filho, JA; Ximenes Filho, R; de Oliveira Britto, AV; Oliveira Souza, AH 2006; 91 Stevenson, AE; Evans, BAJ; Gevers, EF; Elford, C; McLeod, RWJ; Perry, MJ 2009; 296 Gleeson, HK; Souza, AH; Gill, MS; Wieringa, GE; Barretto, ES; Barretto-Filho, JA 2002; 57 Argetsinger, LS; Campbell, GS; Yang, X; Witthuhn, BA; Silvennoinen, O; Ihle, JN 1993; 74 Albert, SG; Mooradian, AD 2004; 89 Møller, N; Gjedsted, J; Gormsen, L; Fuglsang, J; Djurhuus, C 2003; 13 Scavo, LM; Karas, M; Murray, M; Leroith, D 2004; 89 Hohnston, DG; Davis, RR; Prescott, RW 1985; 78 Pereira, RM; Aguiar-Oliveira, MH; Sagazio, A; Oliveira, CR; Oliveira, FT; Campos, VC 2007; 92 Yuen, KC; Dunger, DB 2006; 16 Edge, JA; Harris, DA; Phillips, PE; Pal, BR; Matthews, DR; Dunger, DB 1993; 16 Seufert, J 2004; 53 Yakar, S; Liu, J; Stannard, B; Butler, A; Accili, D; Sauer, B 1999; 96 Wilmore, DW 1999; 33 Møller, N; Flyvbjerg, A; Ørskov, H; Alberti, KGMM 1993 Joaquin, C; Aguilera, E; Granada, ML; Pastor, MC; Salinas, I; Alonso, N 2008; 158 Bratusch-Marrain, PR; Smith, D; DeFronzo, RA 1982; 55 LeRoith, D; Yakar, S 2007; 3 Takala, J; Ruokonen, E; Webster, NR; Nielsen, MS; Zandstra, DF; Vundelinckx, G 1999; 341 Bengtsson, BA 1993; 128 Gill, MS; Toogood, AA; Jones, J; Clayton, PE; Shalet, SM 1999; 84 Li, S; Shin, HJ; Ding, EL; van Dam, RM 2009; 302 Hansen, AP; Johansen, K 1970; 6 Lanes, R; Soros, A; Gunczler, P; Paoli, M; Carrillo, E; Villaroel, O 2006; 149 Fryburg, DA; Louard, RJ; Gerow, KE; Gelfand, RA; Barrett, EJ 1992; 41 Dupont, J; LeRoith, D 2001; 55 |
| References_xml | – volume: 55 start-page: 973 issue: 5 year: 1982 end-page: 82 article-title: The effect of growth hormone on glucose metabolism and insulin secretion in man publication-title: J Clin Endocrinol Metab contributor: fullname: Bratusch-Marrain, PR; Smith, D; DeFronzo, RA – volume: 57 start-page: 89 issue: 1 year: 2002 end-page: 95 article-title: Lipid profiles in untreated severe congenital isolated growth hormone deficiency through the lifespan publication-title: Clin Endocrinol (Oxf) contributor: fullname: Gleeson, HK; Souza, AH; Gill, MS; Wieringa, GE; Barretto, ES; Barretto-Filho, JA – volume: 161 start-page: 837 issue: 6 year: 2009 end-page: 44 article-title: Total and high molecular weight adiponectin are elevated in patients with Laron syndrome despite marked obesity publication-title: Eur J Endocrinol contributor: fullname: Kanety, H; Hemi, R; Ginsberg, S; Pariente, C; Yissachar, E; Barhod, E – volume: 90 start-page: 1864 year: 2005 end-page: 70 article-title: Clinical Review: Growth Hormone and Cardiovascular Risk Factor publication-title: J Clin Endocrinol Metab contributor: fullname: Gola, M; Bonadonna, S; Doga, M; Giustina, A – volume: 296 start-page: 147 issue: 1 year: 2009 end-page: 56 article-title: Does adiposity status influence femoral cortical strength in rodent models of growth hormone deficiency publication-title: Am J Physiol Endocrinol Metab contributor: fullname: Stevenson, AE; Evans, BAJ; Gevers, EF; Elford, C; McLeod, RWJ; Perry, MJ – volume: 331 start-page: 1120 issue: 4 year: 2005 end-page: 6 article-title: Prolactin and growth hormone regulate adiponectin secretion and receptor expression in adipose tissue publication-title: Biochem Biophys Res Commun contributor: fullname: Nilsson, L; Binart, N; Bohlooly, YM; Bramnert, M; Egecioglu, E; Kindblom, J – volume: 6 start-page: 27 issue: 1 year: 1970 end-page: 33 article-title: Diurnal patterns of blood glucose, serum free fatty acids, insulin, glucagon and growth hormone in normals and juvenile diabetics publication-title: Diabetologia contributor: fullname: Hansen, AP; Johansen, K – volume: 12 start-page: 252 issue: 6 year: 2001 end-page: 7 article-title: Signaling pathways activated by the growth hormone receptor publication-title: Trends Endocrinol Metab contributor: fullname: Herrington, J; Carter-Su, C – volume: 16 start-page: 1011 issue: 7 year: 1993 end-page: 8 article-title: Evidence for a role for insulin and growth hormone in overnight regulation of 3-hidroxybutyrate in normal and diabetic adolescent publication-title: Diabetes Care contributor: fullname: Edge, JA; Harris, DA; Phillips, PE; Pal, BR; Matthews, DR; Dunger, DB – volume: 92 start-page: 2353 issue: 6 year: 2007 end-page: 7 article-title: Heterozygosity for a mutation in the growth hormone-releasing hormone receptor gene does not influence adult stature, but affects body composition publication-title: J Clin Endocrinol Metab contributor: fullname: Pereira, RM; Aguiar-Oliveira, MH; Sagazio, A; Oliveira, CR; Oliveira, FT; Campos, VC – volume: 341 start-page: 785 issue: 11 year: 1999 end-page: 92 article-title: Increased mortality associated with growth hormone treatment in critically ill adults publication-title: N Engl J Med contributor: fullname: Takala, J; Ruokonen, E; Webster, NR; Nielsen, MS; Zandstra, DF; Vundelinckx, G – volume: 189 start-page: 47 issue: 1 year: 2006 end-page: 60 article-title: Leptin and atherosclerosis publication-title: Atherosclerosis contributor: fullname: Beltowski, J – volume: 125 start-page: 884 issue: 3253 year: 1957 end-page: 5 article-title: Metabolic effects of human and monkey growth hormone in man publication-title: Science contributor: fullname: Beck, JC; McGarry, EE; Dyrenfurth, I; Venning, EH – volume: 52 start-page: 2483 issue: 10 year: 2003 end-page: 9 article-title: Insulin resistance in the liverspecific IGF-I gene-deleted mouse is abrogated by deletion of the acid-labile subunit of the IGF-binding protein-3 complex: relative roles of growth hormone and IGF-I in insulin resistance publication-title: Diabetes contributor: fullname: Haluzik, M; Yakar, S; Gavrilova, O; Setser, J; Boisclair, Y; LeRoith, D – volume: 84 start-page: 1288 issue: 4 year: 1999 end-page: 95 article-title: Serum leptin response to the acute and chronic administration of growth hormone (GH) to elderly subjects with GH deficiency publication-title: J Clin Endocrinol Metab contributor: fullname: Gill, MS; Toogood, AA; Jones, J; Clayton, PE; Shalet, SM – volume: 146 start-page: 2602 issue: 6 year: 2005 end-page: 9 article-title: Pancreatic islet-specific expression of an insulin-like growth factor-I transgene compensates islet cell growth in growth hormone receptor gene deficient mice publication-title: Endocrinology contributor: fullname: Guo, Y; Lu, Y; Houle, D; Robertson, K; Tang, Z; Kopchick, JJ – volume: 89 start-page: 3543 issue: 7 year: 2004 end-page: 53 article-title: Insulin-like growth factor-I stimulates both cell growth and lipogenesis during differentiation of human mesenchymal stem cells into adipocytes publication-title: J Clin Endocrinol Metab contributor: fullname: Scavo, LM; Karas, M; Murray, M; Leroith, D – volume: 66 start-page: 466 issue: 4 year: 2007 end-page: 74 article-title: Metabolic effects of growth hormone (GH) replacement in children and adolescents with severe isolated GH deficiency due to a GHRH receptor mutation publication-title: Clin Endocrinol (Oxf) contributor: fullname: Gleeson, H; Barreto, ES; Salvatori, R; Costa, L; Oliveira, CR; Pereira, RM – start-page: 224 year: 1993 end-page: 332 publication-title: Growth hormone and Insulin-like growth factors in human and experimental diabetes contributor: fullname: Møller, N; Flyvbjerg, A; Ørskov, H; Alberti, KGMM – volume: 81 start-page: 968 issue: 4 year: 1988 end-page: 75 article-title: Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man publication-title: J Clin Invest contributor: fullname: Ho, KY; Veldhuis, JD; Jonson, ML; Furlanetto, R; Evans, WS; Alberti, KG – volume: 343 start-page: 923 issue: 13 year: 2000 end-page: 30 article-title: Effect of growth hormone treatment on the adult height of children with chronic renal failure: German Study Group for Growth Hormone Treatment in Chronic Renal Failure publication-title: N Engl J Med contributor: fullname: Haffner, D; Schaefer, F; Nissel, R; Wuhl, E; Tonshoff, B; Mehls, O – volume: 78 start-page: 319 issue: 4 year: 1985 end-page: 27 article-title: Regulation of growth hormone secretion in man: a review publication-title: J R Soc Med contributor: fullname: Hohnston, DG; Davis, RR; Prescott, RW – volume: 37 start-page: 612 issue: 5 year: 2006 end-page: 8 article-title: Serum ghrelin and leptin levels in adult growth hormone deficiency syndrome publication-title: Arch Med Res contributor: fullname: Jung, CH; Lee, WY; Rhee, EJ; Kim, SY; Oh, KW; Yun, EJ – volume: 92 start-page: 4664 issue: 12 year: 2007 end-page: 70 article-title: Congenital growth hormone (GH) deficiency and atherosclerosis: effects of GH replacement in GH-naive adults publication-title: J Clin Endocrinol Metab contributor: fullname: Oliveira, JL; Aguiar-Oliveira, MH; D'Oliveira Jr, A; Pereira, RM; Oliveira, CR; Farias, CT – volume: 100 start-page: 1802 issue: 17 year: 1999 end-page: 7 article-title: Circulating insulin and insulin growth factor-1 are independent determinants of left ventricular mass and geometry in essential hypertension publication-title: Circulation contributor: fullname: Verdecchia, P; Reboldi, G; Schillaci, G; Borgioni, C; Ciucci, A; Telera, MP – volume: 93 start-page: 2755 issue: 7 year: 2008 end-page: 9 article-title: Role of growth hormone in regulating lipolysis, proteolysis, and hepatic glucose production during fasting publication-title: J Clin Endocrinol Metab contributor: fullname: Sakharova, AA; Horowitz, JF; Surya, S; Goldenberg, N; Harber, MP; Symons, K – volume: 95 start-page: 693 issue: 2 year: 2010 end-page: 8 article-title: Adipokine profile and urinary albumin excretion in isolated growth hormone deficiency publication-title: J Clin Endocrinol Metab contributor: fullname: Oliveira, CR; Salvatori, R; Meneguz-Moreno, RA; Aguiar-Oliveira, MH; Pereira, RM; Valença, EH – volume: 51 start-page: 559 issue: 5 year: 1999 end-page: 64 article-title: Serum leptin and body composition in children with familial GH deficiency (GHD) due to a mutation in the growth hormone-releasing hormone (GHRH) receptor publication-title: Clin Endocrinol (Oxf) contributor: fullname: de A Barretto, ES; Gill, MS; De Freitas, ME; Magalhães, MM; Souza, AH; Aguiar-Oliveira, MH – volume: 38 start-page: 484 issue: 3 year: 1959 end-page: 8 article-title: Effect of growth hormone on plasma fatty acids publication-title: J. Clin. Invest contributor: fullname: Raben, MS; Hollenberg, CH – volume: 53 start-page: 152 year: 2004 end-page: 8 article-title: Leptin effects on pancreatic beta-cell gene expression and function publication-title: Diabetes contributor: fullname: Seufert, J – volume: 128 start-page: 2 year: 1993 end-page: 5 article-title: The consequences of growth hormone deficiency in adults publication-title: Acta Endocrinol (Copenh) contributor: fullname: Bengtsson, BA – volume: 50 start-page: 2301 issue: 10 year: 2001 end-page: 8 article-title: Pharmacological antilipolysis restores insulin sensitivity during growth hormone exposure publication-title: Diabetes contributor: fullname: Nielsen, S; Møller, N; Christiansen, JS; Jørgensen, JO – volume: 16 start-page: A55 year: 2006 end-page: 61 article-title: Impact of treatment with recombinant human GH and IGF-I on visceral adipose tissue and glucose homeostasis in adults publication-title: Growth Horm IGF Res contributor: fullname: Yuen, KC; Dunger, DB – volume: 113 start-page: 96 issue: 1 year: 2004 end-page: 105 article-title: Inhibition of growth hormone action improves insulin sensitivity in liver IGF-I- deficient mice publication-title: J Clin Invest contributor: fullname: Yakar, S; Setser, J; Zhao, H; Stannard, B; Haluzik, M; Glatt, V – volume: 90 start-page: 1466 issue: 3 year: 2005 end-page: 74 article-title: Growth hormone treatment reduces abdominal visceral fat in postmenopausal women with abdominal obesity: a 12-month placebo-controlled trial publication-title: J Clin Endocrinol Metab contributor: fullname: Franco, C; Brandberg, J; Lonn, L; Andersson, B; Bengtsson, BA; Johannsson, G – volume: 96 start-page: 7324 issue: 13 year: 1999 end-page: 9 article-title: Normal growth and development in the absence of hepatic insulin-like growth factor I publication-title: Proc Natl Acad Sci USA contributor: fullname: Yakar, S; Liu, J; Stannard, B; Butler, A; Accili, D; Sauer, B – volume: 8 start-page: 19 year: 1998 end-page: 23 article-title: Effects of growth hormone treatment on visceral adipose tissue publication-title: Growth Horm IGF Res contributor: fullname: Brummer, RJ – volume: 44 start-page: 1126 issue: 9 year: 1995 end-page: 9 article-title: Growth hormone-deficient adults are insulin-resistant publication-title: Metabolism contributor: fullname: Johansson, JO; Fowelin, J; Landin, K; Lager, I; Bengtsson, BA – volume: 15 start-page: 19 issue: 1 year: 2005 end-page: 27 article-title: Are the metabolic effects of GH and IGF-I separable publication-title: Growth Horm IGF Res contributor: fullname: Mauras, N; Haymond, MW – volume: 55 start-page: 22 year: 2001 end-page: 6 article-title: Insulin and insulin-like growth factor I receptors: similarities and differences in signal transduction publication-title: Horm Res contributor: fullname: Dupont, J; LeRoith, D – volume: 89 start-page: 695 issue: 2 year: 2004 end-page: 701 article-title: Low-dose recombinant human growth hormone as adjuvant therapy to lifestyle modifications in the management of obesity publication-title: J Clin Endocrinol Metab contributor: fullname: Albert, SG; Mooradian, AD – volume: 82 start-page: 1378 issue: 5 year: 1997 end-page: 81 article-title: Increased arterial intima-media thickness in childhood-onset growth hormone deficiency publication-title: J Clin Endocrinol Metab contributor: fullname: Capaldo, B; Patti, L; Oliviero, U; Longobardi, S; Pardo, F; Vitale, F – volume: 41 start-page: 424 issue: 4 year: 1992 end-page: 9 article-title: Growth hormone stimulates skeletal muscle protein synthesis and antagonizes insulin's antiproteolytic action in humans publication-title: Diabetes contributor: fullname: Fryburg, DA; Louard, RJ; Gerow, KE; Gelfand, RA; Barrett, EJ – volume: 33 start-page: 261 year: 1999 end-page: 74 article-title: The use of growth hormone in severely ill patients publication-title: Adv Surg contributor: fullname: Wilmore, DW – volume: 139 start-page: 636 issue: 5 year: 2001 end-page: 42 article-title: Growth hormone improves clinical status in prepubertal children with cystic fibrosis: results of a randomized controlled trial publication-title: J Pediatr contributor: fullname: Hardin, DS; Ellis, KJ; Dyson, M; Rice, J; McConnell, R; Seilheimer, DK – volume: 91 start-page: 2093 issue: 6 year: 2006 end-page: 9 article-title: Lack of evidence of premature atherosclerosis in untreated severe isolated growth hormone deficiency due to a GHRH receptor mutation publication-title: J Clin Endocrinol Metab contributor: fullname: Oliveira, JL; Marques-Santos, C; Barreto-Filho, JA; Ximenes Filho, R; de Oliveira Britto, AV; Oliveira Souza, AH – volume: 81 start-page: 555 issue: 2 year: 1996 end-page: 64 article-title: Insulin resistance in growth hormone-deficient adults: defects in glucose utilization and glycogen synthase activity publication-title: J Clin Endocrinol Metab contributor: fullname: Hew, FL; Koschmann, M; Christopher, M; Rantzau, C; Vaag, A; Ward, G – publication-title: Caracterização clínica e laboratorial de crianças e adolescentes com insensibilidade parcial ao hormônio de crescimento ou ao IGF-I contributor: fullname: Milani, SLS – volume: 74 start-page: 237 issue: 2 year: 1993 end-page: 44 article-title: Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase publication-title: Cell contributor: fullname: Argetsinger, LS; Campbell, GS; Yang, X; Witthuhn, BA; Silvennoinen, O; Ihle, JN – volume: 287 start-page: E405 issue: 3 year: 2004 end-page: 13 article-title: Disruption of growth hormone receptor gene causes diminished pancreatic islet size and increased insulin sensitivity in mice publication-title: Am J Physiol Endocrinol Metab contributor: fullname: Liu, J; Coschigano, KT; Robertson, K; Lipsett, M; Guo, Y; Kopchick, JJ – volume: 99 start-page: 2538 issue: 10 year: 1997 end-page: 44 article-title: Hypoglycemic effect of insulin-like growth factor-1 in mice lacking insulin receptors publication-title: J Clin Invest contributor: fullname: Di Cola, G; Cool, MH; Accili, D – volume: 14 start-page: 449 issue: 6 year: 2004 end-page: 54 article-title: Serum adiponectin levels in adult growth hormone deficiency and acromegaly publication-title: Growth Horm IGF Res contributor: fullname: Fukuda, I; Hizuka, N; Ishikawa, Y; Itoh, E; Yasumoto, K; Murakami, Y – volume: 23 start-page: S202 issue: 6 year: 1999 end-page: 9 article-title: Use of growth hormone and other anabolic agents in AIDS wasting publication-title: JPEN J Parenter Enteral Nutr contributor: fullname: Mulligan, K; Tai, VW; Schambelan, M – volume: 13 start-page: S18 year: 2003 end-page: 21 article-title: Effects of growth hormone on lipid metabolism in humans publication-title: Growth Horm IGF Res contributor: fullname: Møller, N; Gjedsted, J; Gormsen, L; Fuglsang, J; Djurhuus, C – volume: 8 start-page: 115 issue: 2 year: 1987 end-page: 31 article-title: Effect of growth hormone on carbohydrate and lipid metabolism publication-title: Endocr Rev contributor: fullname: Davidson, MB – volume: 72 start-page: 51 issue: 1 year: 1991 end-page: 9 article-title: Dual defects in pulsatile growth hormone secretion and clearance subserve the hyposomatotropism of obesity in man publication-title: J Clin Endocrinol Metab contributor: fullname: Veldhuis, JD; Iranmanesh, A; Ho, KK; Waters, MJ; Johnson, ML; Lizarralde, G – volume: 158 start-page: 483 issue: 4 year: 2008 end-page: 90 article-title: Effects of GH treatment in GH deficiency adults on adiponectin, leptin and pregnancy-associated plasma protein-A publication-title: Eur J Endocrinol contributor: fullname: Joaquin, C; Aguilera, E; Granada, ML; Pastor, MC; Salinas, I; Alonso, N – volume: 149 start-page: 324 issue: 3 year: 2006 end-page: 9 article-title: Growth hormone deficiency, low levels of adiponectin and unfavorable plasma lipid and lipoproteins publication-title: J Pediatr contributor: fullname: Lanes, R; Soros, A; Gunczler, P; Paoli, M; Carrillo, E; Villaroel, O – volume: 3 start-page: 302 issue: 3 year: 2007 end-page: 10 article-title: Mechanisms of disease: metabolic effects of growth hormone and insulin-like growth factor 1 publication-title: Nat Clin Pract Endocrinol Metab contributor: fullname: LeRoith, D; Yakar, S – volume: 87 start-page: 2018 issue: 5 year: 2002 end-page: 23 article-title: Familial isolated growth hormone deficiency is associated with increased systolic blood pressure, central obesity and dyslipidemia publication-title: J Clin Endocrinol Metab contributor: fullname: Barreto-Filho, JA; Alcântara, MR; Salvatori, R; Barreto, MA; Sousa, AC; Bastos, V – volume: 84 start-page: 453 issue: 2 year: 1999 end-page: 7 article-title: Growth hormone (GH) treatment reverses early atherosclerotic changes in GH-deficient adults publication-title: J Clin Endocrinol Metab contributor: fullname: Pfeifer, M; Verhovec, R; Zizek, B; Prezely, J; Poredos, P; Clayton, RN – volume: 24 start-page: 435 issue: 3 year: 2004 end-page: 44 article-title: Expression, regulation, and function of IGF-I, IGF-IR, and IGF-I binding proteins in blood vessels publication-title: Arterioscler Thromb Vasc Biol contributor: fullname: Delafontaine, P; Song, YH; Li, Y – volume: 302 start-page: 179 issue: 2 year: 2009 end-page: 88 article-title: Adiponectin levels and risk of type 2 diabetes: a systematic review and meta-analysis publication-title: JAMA contributor: fullname: Li, S; Shin, HJ; Ding, EL; van Dam, RM |
| SSID | ssj0022735 |
| Score | 1.7440821 |
| Snippet | O hormônio de crescimento (GH), principal regulador do crescimento pós-natal, tem importantes ações metabólicas em diferentes tecidos, sinérgicas ou até... |
| SourceID | doaj scielo |
| SourceType | Open Website Open Access Repository |
| StartPage | 434 |
| SubjectTerms | CARDIAC & CARDIOVASCULAR SYSTEMS factor de crecimiento insulin-like I grelina Lipólisis metabolismo resistencia a la insulina |
| Title | Papel emergente do eixo GH/IGF-I no controle cardiometabólico |
| URI | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2011001400012&lng=en&tlng=en https://doaj.org/article/f3be550df762437988b950010416cce4 |
| Volume | 97 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3LSsQwFA0yC3EjPnF8kYXgKkw7STrJRlBxHsKICwe6C80LhLEVp4L_5Sf4Y96kEQZcuHHTRaG0nHvTc0977wlCF4YaqZ03kLyMEUZ1QaT0FdEghyw3kEU2zA7PH4rpgt2XvFzb6iv0hHX2wB1wA0-1gyraeli1wTtPCC15dJXJC2Nc5wSayR8xlaQWkHJoXszhVUxYPspSZxeXWZgNLgoCxFhG7gsKI3B-8uwPjqGwqJbrLDPeQdupPMTX3WPtog1X76HNefoBvo-uHkO_Enbd0GTrsG2we_5o8GQ6mE3GZIbrBqf2c4dNbDZ9cW2lvz6XEPMDtBjfPd1OSdoCgVgofIaEFZVg1Yh7C7TuM4Ay6KvMeK-DGRtwq60MHVrPMxNmaikgJbgxDHia6hGlh6hXN7U7QlgAWkNpLZRQElScERYuESBRNQeEc9ZHNwEA9dq5XKjgOx1PQDRUiob6Kxp9dNnBp9JSWKmIt_qF9_F_3O4EbcVvvHE28BT12rd3dwZFQqvPYz7AcVLm32mSsm4 |
| link.rule.ids | 230,315,783,787,867,888,2109,27936,27937 |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Papel+emergente+do+eixo+GH%2FIGF-I+no+controle+cardiometab%C3%B3lico&rft.jtitle=Arquivos+brasileiros+de+cardiologia&rft.au=Oliveira%2C+Carla+R.P&rft.au=Meneguz-Moreno%2C+Rafael+A&rft.au=Aguiar-Oliveira%2C+Manuel+H&rft.au=Barreto-Filho%2C+Jos%C3%A9+A.+S&rft.date=2011-11-01&rft.pub=Sociedade+Brasileira+de+Cardiologia+-+SBC&rft.issn=1678-4170&rft.volume=97&rft.issue=5&rft.spage=434&rft.epage=439&rft_id=info:doi/10.1590%2FS0066-782X2011001400012&rft.externalDocID=S0066_782X2011001400012 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1678-4170&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1678-4170&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1678-4170&client=summon |